Seçili Antidepresan Bileşiklerin Atıksu Arıtma Tesislerinde Tespiti, İzlenmesi ve Arıtılabilirliğinin İncelenmesi: Erzurum Kentsel Atıksu Arıtma Tesisi Örneği

Abstract

Bu çalışmada Covid-19 pandemisi sonrası küresel ölçekte kullanımı hızla artan antidepresan (AD) gruba ait farmasötik bileşiklerden Mirtazepine, Citalopram, Escitalopram, Mianserin, Doxepin, Clomipramine, Opipramol’den oluşan 7 hedef bileşiğin Erzurum Kentsel AAT’nde kalıntılarının tespit edilmesi, izlenmesi ve arıtılabilirliklerinin belirlenmesi amacıyla Aralık 2020-Kasım 2021 döneminde 12 ay boyunca numune alımı gerçekleştirilmiştir. Aynı zamanda biyolojik bir arıtma tesisi olan Erzurum Kentsel AAT giriş ve çıkış deşarj öncesi noktalarından alınan numunelerde hedef AD bileşiklerin tespit edilmesinden sonra tesisteki arıtılabilirlikleri incelenmiştir. AD gruba ait seçili farmasötik bileşik kalıntıları çalışma süresince tesisin giriş atıksu ve çıkış deşarj öncesi noktalarından alınan numunelerde önce sıvı-sıvı ekstraksiyon yöntemi kullanılarak etil asetat (EtOAc) ile yoğunlaştırılmış ardından LC-MS/MS metodu ile µg/L seviyesinde analiz edilmiştir. Elde edilen analiz sonuçlarından yola çıkılarak 7 hedef AD farmasötik bileşiğin tesisteki arıtma verimi hesaplanmıştır. Aynı dönemde tesisten aylık olarak alınan iletkenlik, AKM, KOİ, BOİ5, TN’den oluşan tesis işletme parametrelerinin tesisteki giderim verimleri hesaplanarak, hedef AD farmasötik bileşiklerin arıtılabilirliği ile ilişkisi incelenmiştir.

Keywords

• Farmasötikler
• Antidepresan
• Erzurum Biyolojik Atıksu Arıtma Tesisi
• Arıtma Verimi

The Detection, Monitoring and Treatability Studies of Selected Antidepressants in Wastewater Treatment Plants: The Case Study for Erzurum Urban Wastewater Treatment Plant

Abstract

In this study, it was aimed to detect and monitor the 7 target residuals compounds consisting of Mirtazepine, Citalopram, Escitalopram, Mianserin, Doxepin, Clomipramine, Opipramol belonging to the antidepressant group of pharmaceuticals, increased using rapidly after the Covid-19 pandemic, in Erzurum Urban WWTP during 12 months between December 2020-November 202 post-pandemic period. Erzurum Urban WWTP is a biological treatment plant, after the determination of the target antidepressant compounds in the samples taken from the wastewater inlet and outlet before the discharge points, their treatability in the facility was also examined. Samples taken from the inlet wastewater and outlet pre-discharge points of the WWTP were first concentrated with ethyl acetate (EtOAc) using the liquid-liquid extraction method and then it was analyzed at the µg/L level via LC-MS/MS method. Based on the analysis results, the treatment efficiency of 7 target pharmaceutical compounds in the facility was calculated. In the same period, the removal efficiencies of the plant operating parameters, consisting of conductivity, AKM, COD, BOD5, TN, taken monthly from the plant, were also calculated and their relationship with the treatability of the target pharmaceutical compounds was investigated.

Keywords

• Pharmaceuticals
• Antidepressants
• Erzurum Biological Wastewater Treatment Plant
• Treatment Efficiency

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