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Süt ineklerinde klinik endometritisin tedavisi ve gebelik oranı üzerine N-asetilsistein’in etkisi

Year 2014, Volume: 30 Issue: 3, 133 - 137, 01.09.2014

Abstract

Amaç: Bu çalışmada süt ineklerinde klinik endometritisin tedavisi ve gebelik oranı üzerine N-asetilsistein (NAS)’in etkisinin belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışma, ticari bir süt işletmesinde 50-60 günlük gönüllü bekleme süresinden sonra endometritisin klinik bulgularını gösteren 36 inek üzerinde gerçekleştirildi. Klinik endometritis, vajinada belirlenen uterus akıntısının değerlendirilmesiyle tanımlandı. İneklerden servikal svap örnekleri mikroorganizma ve tedavi için en etkili antibakteriyel ajanı belirlemek için toplandı. İnekler rastgele NAS tedavisi yapılan (NAS-T) ve yapılmayan (nNAS-T) olmak üzere iki gruba ayrıldı. NAS-T grubuna (n=18) %2’lik NAS uygulamasından 12 saat sonra amoksisilin trihidrat+potasyum klavulanat (3500 mg+875 mg) uygulaması yapıldı ve bu uygulama üç gün tekrar edildi. nNAS-T grubuna (n=18), NAS-T grubunda uygulanan tedavi protokolündeki NAS uygulaması yerine 100 mL serum fizyolojik uygulaması yapıldı. Tedavi oranı, tedaviyi takiben gerçekleşen ilk doğal östrusta klinik endometritisin bulgularını göstermeyen (vaginal muayenede şeffaf veya yarı şeffaf mukus) ineklerin oranı olarak tanımlandı. Hayvanlar tedaviden sonraki ilk doğal östrusta suni yolla tohumlandı. Bulgular: NAS-T grubunda tedavi (%83.3) ve gebelik (%66.7) oranlarının nNAS-T grubuna (sırasıyla %55.5 ve %27.8) göre önemli derecede yüksek olduğu belirlendi (P<0.05) Öneri: İneklerde klinik endometritisin tedavisinde NAS kullanımı, tedavi başarısını ve gebelik oranını artırabilir.

The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows

Year 2014, Volume: 30 Issue: 3, 133 - 137, 01.09.2014

Abstract

Aim: The objective of this study was to investigate the effect of N-acetylcysteine (NAC) on the treatment of the clinical endometritis and pregnancy rate in dairy cows. Materials and Methods: This study was performed on 36 cows with clinical signs of endometritis after VWP (voluntary waiting period, 50-60 days) on a commercial dairy farm. The clinical endometritis was diagnosed by evaluation of uterine discharge detected in the vagina. Cervical swab samples were collected to determine microorganism and the most effective antibacterial agent for the treatment. Cows were randomly allocated to NAC treatment (NAC-T) and non-NAC treatment (nNAC-T) groups. The NAC-T group (n=18) received an intrauterine infusion of amoxicillin trihydrate+potassium clavulanate (3500 mg+875 mg) in 100 mL dosages after 12 hours of an intrauterine infusion of 2% NAC during three days. Saline (total volume 100 mL) to the nNAC-T group (n=18) was given instead of NAC in the same protocol of the NAC-T group. The clinical cure rate was described as the percentage of cows with no signs of clinical endometritis (the clear or translucent mucus at vaginal examination), at the examination in first natural estrus following treatment. Animals were artificially inseminated following the first natural estrus after treatment. Results: The clinical cure (83.3%) and pregnancy rates (66.7%) in the NAC-T group were significantly higher than those (55.5% and 27.8%, respectively) of nNAC-T group (P<0.05). Conclusions: The usage of NAC for the treatment of the clinical endometritis in cows may increase the success of therapy and the improvement of pregnancy rate.

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Details

Other ID JA62EC66KG
Journal Section Research
Authors

Bunyamin Tras This is me

Dursun A. Dinc This is me

Kamil Uney This is me

Publication Date September 1, 2014
Published in Issue Year 2014 Volume: 30 Issue: 3

Cite

APA Tras, B., Dinc, D. A., & Uney, K. (2014). The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows. Eurasian Journal of Veterinary Sciences, 30(3), 133-137.
AMA Tras B, Dinc DA, Uney K. The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows. Eurasian J Vet Sci. September 2014;30(3):133-137.
Chicago Tras, Bunyamin, Dursun A. Dinc, and Kamil Uney. “The Effect of N-Acetylcysteine on the Treatment of Clinical Endometritis and Pregnancy Rate in Dairy Cows”. Eurasian Journal of Veterinary Sciences 30, no. 3 (September 2014): 133-37.
EndNote Tras B, Dinc DA, Uney K (September 1, 2014) The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows. Eurasian Journal of Veterinary Sciences 30 3 133–137.
IEEE B. Tras, D. A. Dinc, and K. Uney, “The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows”, Eurasian J Vet Sci, vol. 30, no. 3, pp. 133–137, 2014.
ISNAD Tras, Bunyamin et al. “The Effect of N-Acetylcysteine on the Treatment of Clinical Endometritis and Pregnancy Rate in Dairy Cows”. Eurasian Journal of Veterinary Sciences 30/3 (September 2014), 133-137.
JAMA Tras B, Dinc DA, Uney K. The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows. Eurasian J Vet Sci. 2014;30:133–137.
MLA Tras, Bunyamin et al. “The Effect of N-Acetylcysteine on the Treatment of Clinical Endometritis and Pregnancy Rate in Dairy Cows”. Eurasian Journal of Veterinary Sciences, vol. 30, no. 3, 2014, pp. 133-7.
Vancouver Tras B, Dinc DA, Uney K. The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows. Eurasian J Vet Sci. 2014;30(3):133-7.