Iatrogenic steroid hepatopathy in a dog

Year 2015, Volume: 31 Issue: 2, 127 - 131, 01.06.2015

Aliye Sağkan Öztürk Alper Ertürk

Abstract

Steroid hepatopathy is an iatrogenic disorder developed secondary
the as a result of particularly faulty/unconscious
corticosteroids applications. In this report, clinical, radyographic
and ultrasonographic data of 18 year old male Terrier
dog suffering from steroid hepatopathy was evaluated. In
anamnesis, the owner of the dog used corticosteroid (three
months prednisolone and one month dexamethasone) in
four months. In clinical examination revealed lethargy, pale
mucosa membranes and incoordination. In laboratory analyses,
increases of alkaline phosphatase and gamma glutamyl
transferase levels ten times, alanine transaminase seven
times, aspartate aminotransferase <2 times, blood urea nitrogen
and cholesterol almost two times were increased in
laboratory analyses. In the urine sediment leucine crystals
was appeared. Increased echogenicity and heterogenic appearance
in liver and hyperechogenicity in gallbladder were
seen in the ultrasonographic examination of dog. Despite
performed the support treatment, the dog died after 45 days.
In conclusion, this case evaluated that faulty and/or long
time corticosteroids may result steroid hepatopathy, it is necessary
to monitor the corticosteroid therapy laboratory and
ultrasonographic examinations can be utilized in monitoring
and diagnostics.

Keywords

Dog, steroid hepatopathy

Bir köpekte iatrojenik steroid hepatopati

Abstract

Steroid hepatopati, hatalı/bilinçsiz steroid kullanımı sonucu
sekonder olarak gelişen iatrojenik bir bozukluktur. Sunulan
olguda steroid hepatopatili 18 yaşlı Terrier ırkı erkek bir
köpekte klinik, biyokimyasal, radyografi ve ultrasonografi
bulguları değerlendirildi. Anemnezde hasta sahibinin dört
ay kortikosteroid (üç ay prednizolon ve bir ay deksametazon)
kullandığı öğrenildi. Klinik muayenede halsizlik, mukoz
membranlarda solgunluk ve koordinasyon bozukluğu
gözlendi. Laboratuvar muayenelerinde alkalen fosfataz ve
gamma glutamil transferaz seviyeleri >10 kat, serum alanin
aminotransferaz 7 kat, aspartat aminotransferaz konsantrasyonunda

Keywords

Köpek, steroid hepatopati

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