Mısır’da bir koyun çiftliğinde ovine pulmoner adenokarsinoma

Year 2014, Volume: 30 Issue: 1, 39 - 43, 01.03.2014

Khaled Radad Sary Khalil

Abstract

Ovine pulmonar adenokarsinoma koyunlarda retrovirüsün
neden olduğu akciğer kanseridir. Mevcut vaka raporunun
amacı Mısır’da bir koyun çiftliğinde hastalığın histopatalojik
ve klinik tanımı yapmaktır. Çiftlikteki 4 adeti ölü ve 5 adeti
hasta genç koyuna klinik, makroskobik ve histopatalojik de-
ğerlendirmeler yapıldı. Histopatalojik incelemeler için akci-
ğer, mediastinal lenf yumruları, karaciğer, kalp, böbrek ve beyin
dokusu örnekleri alındı. Örnekler %10 formalde tespit
edildi ve ışık mikroskopta incelendi. İncelene hayvanlarda
ağır kilo kaybı ve burunda mokuid akıntı gözlendi. Nekropside
akciğer çok sayıda grimsi köpüklü sıvı ve pleural boşluk
mukois sıvı birikimi gözlendi. Histopatalojik incelemede çok
sayıda alveolar epitek kökenli kapsülsüz neoplastik odaklar
tespit edildi. Neoplastik odak kübik ve sütun hücrelerden
oluşmaktaydı. Bunlar düzenli papillar ve asiner şekilde belirlendi.
Proliferatif hücreler küçük damar hücreleri ve fibroblast
içeren yumuşak doku ile desteklenmiş olarak belirlendi.
Neoplastic odaklarla ilişkili alveolar boşluklarda çok sayıda
şişkin makrofaj varlığı belirgindi. Sonuç olarak ovine pulmonar
adenokarsinomalar için kübik ve uzun hücrelerle kaplı
alveolar epitelin transformasyonu ve burundan mukoid sıvı
akıntısı patognomiktir.

Keywords

Adenokarsinoma, histopatoloji, akciğer, koyun

Natural ovine pulmonary adenocarcinoma in an Egyptian sheep farm

Abstract

Ovine pulmonary adenocarcinoma is a naturally occurring
retrovirus-induced contagious lung neoplasm in sheep. The
current report aims to describe clinical and histopathological
characteristics of the disease in an Egyptian sheep farm.
In which, 4 dead and 5 sick young sheep were subjected to
clinical, gross and histopathological examinations. For histopathological
examination, tissue specimens were taken
from lungs, mediastinal lymph nodes, liver, heart, kidneys
and brain, fixed in 10% neutral buffered formalin and processed
for light microscopy. Examined animals showed release
of copious amount of mucoid fluid from their nostrils
and marked loss of body weight. At necropsy, there were
many solid grayish nodules exuding frothy fluid in the lungs
and accumulation of mucoid fluid in the pleural cavity. Histopathological
examination revealed presence of many nonencapsulated
neoplastic foci originating from the alveolar
epithelial lining. Neoplastic foci consisted of cuboidal and
columnar cells that arranged in papillary and acinar forms.
Proliferating cells appeared supported by loose connective
tissue containing some fibroblasts and small blood vessels.
Prominently, there was large number of swollen and ruffled
macrophages in alveolar spaces adjacent to neoplastic foci.
In conclusions, release of copious amount of mucoid fluid
from nostrils and transformation of alveolar epithelial lining
into cuboidal and columnar cells are pathognomonic for
ovine pulmonary adenocarcinoma.

Keywords

Adenocarcinoma, histopathology, lungs, sheep

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