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Sefriaksonun kan basıncı ile solunuma etkisi ve anajejik ile antipretik aktiviteleri

Year 2012, Volume: 28 Issue: 1, 41 - 46, 01.03.2012

Abstract

Amaç: Araştırmanın amacı seftriaksonun köpeklerde kan basıncı ve solunuma etkisini aratırmaktır. Ayrıca seftriaksonun fare ve ratlarda anajezik ve antipretik etkiliği de araştırıldı.Gereç ve Yöntem: Faklı dozlarda seftriaksonun (26.66, 53.33, 106.66 mg/kg, IV) anestezi altındaki köpeklerde kan basıncı ve solunuma etkisi belirlendi. İki farklı dozda seftriaksonun ise fare ve ratlarda anajezik ve antipretik etkinliği belirlendi.Bulgular: Seftriaksonun anestezi altındaki köpeklerin kan basıncı ve solunuma etkisinin olmadığı belirlendi. Ancak seftriaksonun (260 ve 520 mg/kg) dört saat süresince analjezik ve 180 ile 360 mg/kg dozlarda sırasıyla 2.5 ve 1.5 saat süresince antipretik etkinlik gösterdiği belirlendi. Öneri: Seftriakson bakterial ve ateşli enfeksiyonlarda antibakteriyel, analjezik ve antipretik etkinliğinden dolayı tercih edilebilir.

Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities

Year 2012, Volume: 28 Issue: 1, 41 - 46, 01.03.2012

Abstract

Aim: The aim of this study was to determine the effect of ceftriaxone on blood pressure and respiration in dog. In addition, analgesic and antipyretic activities of ceftriaxone were investigated in mice and rats.Materials and Methods: Effect of different doses of ceftriaxone (26.66, 53.33, 106.66 mg/kg, IV) on blood pressure and respiration rate were determined in anesthetized dogs. Analgesic and antipyretic activities of two different doses of ceftriaxone were investigated in mice and rats, respectively.Results: Ceftriaxone had no effect on blood pressure and rate of respiration in anesthetized dogs. However, ceftriaxone (260 and 520 mg/kg) had a significant analgesic effect for four hours and had a significant antipyretic effect at 2.5 and 1.5 hours at doses of 180 and 360 mg/kg, respectively.Conclusion: Ceftriaxone is preferable in bacterial infections or feverish conditions owing to its antibacterial, antipyretic and analgesic activities.

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Details

Other ID JA69ME27BB
Journal Section Research
Authors

Mohamed Aboubakr This is me

Mossad Elsayed This is me

Ashraf Elkomy This is me

Publication Date March 1, 2012
Published in Issue Year 2012 Volume: 28 Issue: 1

Cite

APA Aboubakr, M., Elsayed, M., & Elkomy, A. (2012). Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities. Eurasian Journal of Veterinary Sciences, 28(1), 41-46.
AMA Aboubakr M, Elsayed M, Elkomy A. Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities. Eurasian J Vet Sci. March 2012;28(1):41-46.
Chicago Aboubakr, Mohamed, Mossad Elsayed, and Ashraf Elkomy. “Effect of Ceftriaxone on Blood Pressure, Respiration and Its Analgesic and Antipyretic Activities”. Eurasian Journal of Veterinary Sciences 28, no. 1 (March 2012): 41-46.
EndNote Aboubakr M, Elsayed M, Elkomy A (March 1, 2012) Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities. Eurasian Journal of Veterinary Sciences 28 1 41–46.
IEEE M. Aboubakr, M. Elsayed, and A. Elkomy, “Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities”, Eurasian J Vet Sci, vol. 28, no. 1, pp. 41–46, 2012.
ISNAD Aboubakr, Mohamed et al. “Effect of Ceftriaxone on Blood Pressure, Respiration and Its Analgesic and Antipyretic Activities”. Eurasian Journal of Veterinary Sciences 28/1 (March 2012), 41-46.
JAMA Aboubakr M, Elsayed M, Elkomy A. Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities. Eurasian J Vet Sci. 2012;28:41–46.
MLA Aboubakr, Mohamed et al. “Effect of Ceftriaxone on Blood Pressure, Respiration and Its Analgesic and Antipyretic Activities”. Eurasian Journal of Veterinary Sciences, vol. 28, no. 1, 2012, pp. 41-46.
Vancouver Aboubakr M, Elsayed M, Elkomy A. Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities. Eurasian J Vet Sci. 2012;28(1):41-6.