Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

Ender Yarsan; Arif Altıntas; Dinc Essiz; Levent Altintas; Mert Pekcan; Gulay Ciftci; İshraga G. Ibrahim

Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

Year 2010, Volume: 26 Issue: 1, 21 - 24, 01.03.2010

Ender Yarsan Arif Altıntas Dinc Essiz Levent Altintas Mert Pekcan Gulay Ciftci İshraga G. Ibrahim

Abstract

Aim: The effects of renal failure on the pharmacokinetics of sulphamethoxazole were investigated after oral administration of 100 mg/kg of the drug using a mice model of mercury chloride-induced renal failure. Materials and Methods: Mercury chloride was given to mice at the doses of 3 and 6 mg/kg. Plasma sulphamethoxazole concentrations were measured by spectrophotometer. Plasma concentration-time data were fitted to a two-compartment open model.Results: Significant findings (p<0.05) were observed for absorption (AUC and t1/2a) and elimination (t1/2β and MRT) phases of sulphamethoxazole related with renal failure. Also area under the curve value decreased, and mean residence time value increased with renal failure (p<0.05). Conclusion: Study result showed that dosage and administration intervals of sulphamethoxazole were important for patients with renal failure

Keywords

Sulphamethoxazole, pharmacokinetic, renal failure, mercury chloride

Farelerde Cıva Klorür ile Oluşturulan Böbrek Hasarının Oral Yolla Uygulanan Sülfametaksazolün Farmakokinetiği Üzerine Etkisi

Year 2010, Volume: 26 Issue: 1, 21 - 24, 01.03.2010

Ender Yarsan Arif Altıntas Dinc Essiz Levent Altintas Mert Pekcan Gulay Ciftci İshraga G. Ibrahim

Abstract

Amaç: Bu çalışmada, deneysel olarak cıva klorür ile böbrek hasarı oluşturulmuş farelerde 100 mg/kg dozda oral yolla uygulanan sülfametoksazolün farmakokinetiği değerlendirildi. Gereç ve Yöntem: Cıva klorür farelere 3 ve 6 mg/kg dozlarında verildi. Plazma sülfametaksazol konsantrasyonları spektrofotometre ile ölçüldü. Plazma konsantrasyon-zaman verileri dikkate alındığında ilacın 2 kompartmanlı açık modele uygun olduğu görüldü.Bulgular: Böbrek hasarı ile ilişkili olarak sülfametoksazolün emilim (AUC and t1/2a) ve eliminasyon (t1/2β and MRT) fazlarında önemli bulgular (p<0.05) gözlendi. Hasara bağlı olarak eğrinin altında kalan alan değeri düşerken, ortalama kalış zamanında artış tespit edildi (p<0.05) Öneri: Böbrek hasarlı hastalarda, sülfametoksazolün doz ve uygulama aralıklarının hasarın derecesine göre belirlenmesi çok önemlidir.

Keywords

Sülfametoksazol, farmakokinetik, böbrek yetmezliği, cıva klorür

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Details

Other ID	JA69SD72BP
Journal Section	Research
Authors	Ender Yarsan This is me Arif Altıntas This is me Dinc Essiz This is me Levent Altintas This is me Mert Pekcan This is me Gulay Ciftci This is me İshraga G. Ibrahim This is me
Publication Date	March 1, 2010
Published in Issue	Year 2010 Volume: 26 Issue: 1

Cite

APA	Yarsan, E., Altıntas, A., Essiz, D., Altintas, L., et al. (2010). Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences, 26(1), 21-24.
AMA	Yarsan E, Altıntas A, Essiz D, Altintas L, Pekcan M, Ciftci G, Ibrahim İG. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian J Vet Sci. March 2010;26(1):21-24.
Chicago	Yarsan, Ender, Arif Altıntas, Dinc Essiz, Levent Altintas, Mert Pekcan, Gulay Ciftci, and İshraga G. Ibrahim. “Influence of Mercury Chloride-Renal Failure on Pharmacokinetics of Sulphamethoxazole After Oral Administration in Mice”. Eurasian Journal of Veterinary Sciences 26, no. 1 (March 2010): 21-24.
EndNote	Yarsan E, Altıntas A, Essiz D, Altintas L, Pekcan M, Ciftci G, Ibrahim İG (March 1, 2010) Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences 26 1 21–24.
IEEE	E. Yarsan, A. Altıntas, D. Essiz, L. Altintas, M. Pekcan, G. Ciftci, and İ. G. Ibrahim, “Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice”, Eurasian J Vet Sci, vol. 26, no. 1, pp. 21–24, 2010.
ISNAD	Yarsan, Ender et al. “Influence of Mercury Chloride-Renal Failure on Pharmacokinetics of Sulphamethoxazole After Oral Administration in Mice”. Eurasian Journal of Veterinary Sciences 26/1 (March 2010), 21-24.
JAMA	Yarsan E, Altıntas A, Essiz D, Altintas L, Pekcan M, Ciftci G, Ibrahim İG. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian J Vet Sci. 2010;26:21–24.
MLA	Yarsan, Ender et al. “Influence of Mercury Chloride-Renal Failure on Pharmacokinetics of Sulphamethoxazole After Oral Administration in Mice”. Eurasian Journal of Veterinary Sciences, vol. 26, no. 1, 2010, pp. 21-24.
Vancouver	Yarsan E, Altıntas A, Essiz D, Altintas L, Pekcan M, Ciftci G, Ibrahim İG. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian J Vet Sci. 2010;26(1):21-4.