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AMİGDALİN İLE ZEHİRLENEN KOYUNLARIN KOBALT KLORÜR VE SODYUM TİYOSÜLFAT İLE TEDAVİSİ

Year 1996, Volume: 12 Issue: 2, 43 - 52, 01.06.1996

Abstract

Bu çalışma, amigdalin ile zehirlenan koyunların tedavisinde kullanılan kobalt klorür ve sodyum tiyosülfatın et­kilerinin karşılaştırılması amacıyla yapıldı. Araştırmada rumande siyanür ile kan örneklerinde siyanür, tiyosiyanat, he­moglobin ve methemoglobin düzeylerinde meydana gelen değişiklikler belirlendi. Araştırmada yaklaşık olarak 2 ya­şında 16 adet dişi koyun kullanıldı. Üzerinde deneme yapılacak hayvan 1 gün önce akşam saat 17.00'den ertesi gün uygulamalar tamamlanıncaya kadar aç bırakıldı. Böylece yemden ve sudan ileri gelebilecek olan siyanür kon­taminasyonları önlendi. Amigdalin rumen sondası ile 1.5 mg/kg dozunda verildi. Amigdalin verilmesini takiben 1,2.4,8,24,48 ve 72. saatlerde kan ve rumen örnekleri alındı. Rumen örnekleri siyanür düzeyleri, kan örnekleri ise si­yanür. tiyosiyanat, hemoglobin ve methemoglobin düzeyleri yönünden incelendiler. Deneysel olarak oluşturulan si­yanür zehirlenmasinde kobalt klorür 30. dakikada 5,1 O ve 15 mg/kg dozlarında verildiğinde 1 saatte siyanürü 0.21 O' dan dozlara göre 0.079,0.039 ve 0.068 ug/ml değerlerine düşürdü. Buna karşın 30. dakikada verilen sodyum ti­yosülfat ise 1. saatte dozlara göre siyanürü 0.21 O' dan 0.139, 0.165 ve 0.179 ug/ml değerlerine düşürdü. Sodyum :ıitrit sodyum tiyosülfat birlikte verildiğinde 1 saat içerisinde siyanürü 0.210 ug/ml den 0.103 ug/ml düzeyine düşürdü. Si­yanür zehirlenmasinin tedavisinde kullanılan kobalt k.lorürün sodyum tiyosülfattan daha etkili olduğu görüldü

Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin

Year 1996, Volume: 12 Issue: 2, 43 - 52, 01.06.1996

Abstract

The presant experiment was carried out to compare the effects of cobaltous chloride and sodium thi­osulfate used in the treatment of sheep poisoned with amygdalin. In the study, changes occuring levels of eyanide in the rumen liquor and levels of cyanide, thiocyanate, hemoglobin and methemoglobin in the blood, were determined. In the study, sixteen ewes, aged approximately two years old, were used. The animal on which the experiment was made was fasted from 5 p.m. a day ago to the complement of experiment the next day, Thus, eyanide contaminations due to feed and water were prevented. Amygdalin was given through the rumen probe in the doses of 1,5 mg/kg. Samples of rumen and blood were collected at 1,2,4,8,24,72. hours after amygdalin was given. Samples of the rumen were analysed in terms of the levels cyanide. Samples of the blood were analysed in terms of the levels cyanide, thi­ocyanate, hemoglobin and methemoglobin. lt was observed that co b alt chloride given in the dos es of 5,1 O and 15 mg/ kg at thirty minules decreased the level of eyanide from 0,21 O ug/ml to 0.079, 0.039 and 0.068 ug/ml at first hour, res­pectively. On the other hand, it was defined that sodium thiosulfate given in doses of 50, 400 and 600 mg/kg at thirty minutes decreased the level kof eyanide from 0.21 O ug/ml to 0.139, 0.165 and 0.179 u gl ml at first hour, respectively. lt was established that cobaltous chloride + sodium thiosulfate given in the dose of 10+600 mg/kg at thirty minules dec­reased the level of eyanide from 0.21 O u gl ml to 0.103 ug/ml at first hour. Cobaltous chloride u sed in the treatment of the eyanide poisoning was found to be more elfactive than sodium thiosulfate

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Details

Other ID JA73MD52BE
Journal Section Research
Authors

İbrahim Pirinçi This is me

Sadettin Tanyıldızı This is me

Ahmet Ateşşahin This is me

Haki Kara This is me

Songül Özaydın This is me

Publication Date June 1, 1996
Published in Issue Year 1996 Volume: 12 Issue: 2

Cite

APA Pirinçi, İ., Tanyıldızı, S., Ateşşahin, A., Kara, H., et al. (1996). Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin. Eurasian Journal of Veterinary Sciences, 12(2), 43-52.
AMA Pirinçi İ, Tanyıldızı S, Ateşşahin A, Kara H, Özaydın S. Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin. Eurasian J Vet Sci. June 1996;12(2):43-52.
Chicago Pirinçi, İbrahim, Sadettin Tanyıldızı, Ahmet Ateşşahin, Haki Kara, and Songül Özaydın. “Treatment With Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned With Amygdalin”. Eurasian Journal of Veterinary Sciences 12, no. 2 (June 1996): 43-52.
EndNote Pirinçi İ, Tanyıldızı S, Ateşşahin A, Kara H, Özaydın S (June 1, 1996) Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin. Eurasian Journal of Veterinary Sciences 12 2 43–52.
IEEE İ. Pirinçi, S. Tanyıldızı, A. Ateşşahin, H. Kara, and S. Özaydın, “Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin”, Eurasian J Vet Sci, vol. 12, no. 2, pp. 43–52, 1996.
ISNAD Pirinçi, İbrahim et al. “Treatment With Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned With Amygdalin”. Eurasian Journal of Veterinary Sciences 12/2 (June 1996), 43-52.
JAMA Pirinçi İ, Tanyıldızı S, Ateşşahin A, Kara H, Özaydın S. Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin. Eurasian J Vet Sci. 1996;12:43–52.
MLA Pirinçi, İbrahim et al. “Treatment With Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned With Amygdalin”. Eurasian Journal of Veterinary Sciences, vol. 12, no. 2, 1996, pp. 43-52.
Vancouver Pirinçi İ, Tanyıldızı S, Ateşşahin A, Kara H, Özaydın S. Treatment with Cobaltous Chloride and Sodium Thiosulfate in Sheep Poisoned with Amygdalin. Eurasian J Vet Sci. 1996;12(2):43-52.