Current treatment options for carbon monoxide-induced neurological dysfunction
Abstract
Carbon monoxide is an established dangerous toxicant with a complex mechanism of cellular toxicity. It is known to cause various neurological symptoms which can manifest both in acute as well as chronic forms. Delayed neurological deficits are often less recognizable. Radiological findings are also less specific. Hyperbaric oxygen therapy has been the mainstay of treatment over the years but is associated with its own list of complications and controversies. Current management for this important condition is discussed here.
Keywords
References
- [1] Kao L, Nanagas K. Toxicity associated with carbon monoxide. Clin Lab Med 2006;26:99-125.
- [2] Tomaszewski C. Carbon monoxide. In: Goldfrank LR, Flomenbaum NE, Lewin NA, et al, editors. Goldfrank’s toxicologic emergencies. 7th edition. New York: McGraw-Hill; 2002. p. 1478-97.
- [3] Cobb N, Etzel RA. Unintentional carbon monoxide-related deaths in the United States, 1979 through 1988. JAMA 1991;266:659-63.
- [4] Ernst A, Zibrak JD. Carbon monoxide poisoning. N Engl J Med 1998;339:1603-8.
- [5] Abelsohn A, Sanborn MD, Jessiman BJ, Weir E. Identifying and managing adverse environmental health effects. 6. Carbon monoxide poisoning. CMAJ 2002;166:1685-90.
- [6] Raub JA, Mathieu-Nolf M, Hampson NB, Thom SR. Carbon monoxide poisoning--a public health perspective. Toxicology 2000;145:1-14.
- [7] Stewart RD. The effect of carbon monoxide on humans. Annu Rev Pharmacol 1975;15:409-22.
- [8] Mehta SR, Das S, Singh SK. Carbon monoxide poisoning. MJAFI 2007;63:362-5.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Review
Publication Date
May 4, 2019
Submission Date
April 10, 2018
Acceptance Date
July 10, 2018
Published in Issue
Year 2019 Volume: 5 Number: 3