Dynamic thiol-disulphide homeostasis in grade 3-4 gonarthrosis

Year 2019, , 740 - 744, 04.09.2019

Kenan Güvenç , Şahap Cenk Altun , Merve Ergin , Özcan Erel , Faik İlik

https://doi.org/10.18621/eurj.414367

Abstract

Objective:
We
aimed to determine thiol-disulphide homeostasis, which plays a vital role and
to investigate the relationship among homeostatic parameters and disease.

Methods: In
this prospective study, we enrolled 38 patients with osteoarthritis (31 females
and 7 males) and 38 healthy controls (30 females, 8 males volunteers).
Diagnosis of osteoarthritis was made according to the American College of
Rheumatology Criteria. The severity of osteoarthritis was assessed and
classified according to the Kellgren-Lawrence grading scale.

Results: The
mean age was 63.8 (range; 53-74) years in the osteoarthritis group and 65.6 (range;
55-75) years in the control group. There were no significant differences
between the patients and controls in respect to age, gender and body mass index
(p > 0.05). Serum albumin (p = 0.605) and total protein levels (p = 0.605) between patients and controls
were similar. In the osteoarthritis group disulphide/ native thiol percent
ratios and disulphide/ total thiol percent ratios were found to be
statistically higher (p = 0.002 and p = 0.002; respectively) and
native/ total thiol percent ratios were significantly lower than that of the
control group (p = 0.002).

Conclusions: Thiol-disulphide
homeostasis is weakened in osteoarthritis, and the balance shifts to the
disulphide bond formation side. Substitution of thiol deficiency and correction
of thioldisulphide imbalance may be beneficial in the managing treatment of the
disease. Further studies may be needed for evaluating articular fluid
thiol-disulphide homeostasis. 

Keywords

Oxidative stress, osteoarthritis, thiol-disulphide homeostasis

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