The relationship between postoperative atrial fibrillation after coronary artery bypass surgery and inflammation

Abstract

Objectives: Postoperative atrial fibrillation (PoAF) may occur up to 50% after coronary artery bypass grafting (CABG) operations. The most important problems related to this are prolonged hospitalizations, thromboembolic cerebrovascular events and new onset heart failure. In this study, we aimed to investigate the relation of high sensitivity C-reactive protein (hsCRP) and heat shock protein 70 (HSP70) levels and occurrence of PoAF in patients undergoing isolated CABG.

Methods: Patients who underwent elective isolated coronary artery bypass surgery between November 2008 and April 2009 in the Cardiovascular Surgery Clinic of Dıskapı Yıldırım Beyazıt Training and Research Hospital were prospectively included in the study.

Results: A total of 40 patients (20 Off-pump CABG (OPCABG), mean age: 59.3 ± 5.56 years) and 20 On-pump CABG (mean age: 60.7 ± 5.3 years)) were included in the study. PoAF ratio was 25% in on-pump CABG patients and 15% in OPCABG group (p = 0.356). Age and diameters of the heart cavities were statistically significantly higher in patients with POAF in both surgical groups. Left ventricular ejection fraction was significantly lower in patients with PoAF. Preoperative hsCRP, postoperative hsCRP, preoperative HSP70 and postoperative HSP70 levels were significantly higher in patients with PoAF who underwent OPCABG (p = 0.018, p = 0.044, p < 0.001 and p = 0.047; respectively).

Conclusions: As a result, PoAF is undesirable for CABG operations. PoAF can be predicted by evaluating HSP70 and hsCRP values before coronary bypass operations. 

Keywords

• Coronary artery bypass grafting
• postoperative atrial fibrillation
• inflammation
• heat shock protein 70

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