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Mean platelet volume is increased in patients with chronic hepatitis B

Year 2016, Volume: 2 Issue: 2, 132 - 136, 04.07.2016
https://doi.org/10.18621/eurj.2016.5000188880

Abstract

Background. Hepatitis secondary to infection with the hepatitis B virus (HBV) is one of the most common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HBV infection have been recognized. However, the effect of HBV infection on the mean platelet volume (MPV) is unknown. The aim of this study was to assess the MPV, an indicator of platelet activation, in patients with chronic hepatitis B. Methods. The study group consisted of 50 patients with chronic hepatitis B. An age, gender, and body mass index-matched control group consisted of 50 healthy volunteers. All patients and control participants underwent echocardiographic examination. We measured the serum MPV values in patients and control participants. Results. Mean platelet volume was significantly higher among patients with HBV when compared with the control group (9.2±2.2 vs 7.1±1.6 fl, respectively; p<0.001). Conclusion. We have shown that MPV was significantly elevated in patients with chronic hepatitis B compared to control participants. According to our knowledge, there has been no previous study of MPV in chronic HBV patients. Therefore, we have investigated the possible association between HBV infection and MPV. 

References

  • Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97-107.
  • Kwon SY, Lee CH. Epidemiology and prevention of hepatitis B virus infection. Korean J Hepatol 2011;17:87-95.
  • Matsumori A. Symposium on clinical aspects in hepatitis virus infection. 5. Clinical practice of hepatitis: myocardial diseases, nephritis, and vasculitis associated with hepatitis virus. Intern Med 2001;40:182-4.
  • Rong Q, Huang j, Su E, Li J, Li J, Zhang L, et al. Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells. Virol J 2007;4:36.
  • Franceschi S, Lise M, Trepo C, Berthillon P, Chuang SC, Nieters A, et al. Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev 2011;20:208-14.
  • Matsumori A, Ohashi N, Hasegawa K, Sasayama S, Eto T, Imaizumi T, et al. Hepatitis C virüs infection and heart diseases: a multicenter study in Japan. Jpn Circ J 1998;62:389-91.
  • Amirzadegan A, Davoodi G, Boroumand MA, Darabyan S, Dehkordi MR, Goodarzynejad H. Association between hepatitis B surface antibody seropositivity and coronary artery disease. Indian J Med Sci 2007;61:648-55.
  • Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group, Weber R, Sabin C, Reiss P, de Wit S, Worm SW, Law M, et al. HBV or HBV coinfections and risk of myocardial infarction in HIV-infected individuals: the D:A:D Cohort Study. Antivir Ther 2010;15:1077-86.
  • Varol E, Arslan A, Yucel H, Ozaydin M, Erdogan D, Dogan A. Increased mean platelet volume in patients with aortic stenosis. Clin Appl Thromb Hemost 2011;17:E17-20.
  • Varol E, Ozaydin M, Turker Y, Alaca S. Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm. Scand J Clin Lab Invest 2009;69:708-12.
  • Gulcan M, Varol E, Etli M, Aksoy F, Kayan M. Mean platelet volume is increased in patients with deep vein thrombosis. Clin Appl Thromb Hemost 2012;18:427-30.
  • Varol E, Akcay S, Icli A, Ozkan E, Erdogan D, Ozaydin M. M. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc 2010;45:67-72.
  • Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-67.
  • Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al.; American Society of Echocardiography's Nomenclature and Standards Committee; Task Force on Chamber Quantification; American College of Cardiology Echocardiography Committee; American Heart Association; European Association of Echocardiography, European Society of Cardiology. Task Force on Chamber Quantification: Recommendations for chamber quantification. Eur J Echocardiogr 2006;7:79-108.
  • Matsumori A. Hepatitis C virus infection and cardiomyopathies. Circ Res 2005;96:144-7.
  • Matsumori A. Role of hepatitis C virus in cardiomyopathies. Ernst Schering Res Found Workshop 2006:99-120.
  • Demir M, Demir C. Effect of hepatitis B virus infection on right and left ventricular functions. Med Sci Monit. 2012;18: CR587-91.
  • Ishizaka N, Ishizaka Y, Takahashi E, Toda Ei E, Hashimoto H, Ohno M, et al. Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers. Circulation 2002;105:1028-30.
  • Wang L, Geng J, Li J, Li T, Matsumori A, Chang Y, et al. The biomarker N-terminal pro-brain natriuretic peptide and liver diseases. Clin Invest Med 2011;1;34:E30-7.
  • Kucukazman M, Ata N, Yavuz B, Dal K, Ertugrul DT, Yalcin AA, et al. Elevation of B-type natriuretic Peptide level in asymptomatic hepatitis B virus-positive patients is not associated with abnormalities of cardiac function. Med Princ Pract 2012;21:150-5.
  • Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148-56.
  • Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399-404.
  • Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.
Year 2016, Volume: 2 Issue: 2, 132 - 136, 04.07.2016
https://doi.org/10.18621/eurj.2016.5000188880

Abstract

References

  • Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97-107.
  • Kwon SY, Lee CH. Epidemiology and prevention of hepatitis B virus infection. Korean J Hepatol 2011;17:87-95.
  • Matsumori A. Symposium on clinical aspects in hepatitis virus infection. 5. Clinical practice of hepatitis: myocardial diseases, nephritis, and vasculitis associated with hepatitis virus. Intern Med 2001;40:182-4.
  • Rong Q, Huang j, Su E, Li J, Li J, Zhang L, et al. Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells. Virol J 2007;4:36.
  • Franceschi S, Lise M, Trepo C, Berthillon P, Chuang SC, Nieters A, et al. Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev 2011;20:208-14.
  • Matsumori A, Ohashi N, Hasegawa K, Sasayama S, Eto T, Imaizumi T, et al. Hepatitis C virüs infection and heart diseases: a multicenter study in Japan. Jpn Circ J 1998;62:389-91.
  • Amirzadegan A, Davoodi G, Boroumand MA, Darabyan S, Dehkordi MR, Goodarzynejad H. Association between hepatitis B surface antibody seropositivity and coronary artery disease. Indian J Med Sci 2007;61:648-55.
  • Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group, Weber R, Sabin C, Reiss P, de Wit S, Worm SW, Law M, et al. HBV or HBV coinfections and risk of myocardial infarction in HIV-infected individuals: the D:A:D Cohort Study. Antivir Ther 2010;15:1077-86.
  • Varol E, Arslan A, Yucel H, Ozaydin M, Erdogan D, Dogan A. Increased mean platelet volume in patients with aortic stenosis. Clin Appl Thromb Hemost 2011;17:E17-20.
  • Varol E, Ozaydin M, Turker Y, Alaca S. Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm. Scand J Clin Lab Invest 2009;69:708-12.
  • Gulcan M, Varol E, Etli M, Aksoy F, Kayan M. Mean platelet volume is increased in patients with deep vein thrombosis. Clin Appl Thromb Hemost 2012;18:427-30.
  • Varol E, Akcay S, Icli A, Ozkan E, Erdogan D, Ozaydin M. M. Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc 2010;45:67-72.
  • Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-67.
  • Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al.; American Society of Echocardiography's Nomenclature and Standards Committee; Task Force on Chamber Quantification; American College of Cardiology Echocardiography Committee; American Heart Association; European Association of Echocardiography, European Society of Cardiology. Task Force on Chamber Quantification: Recommendations for chamber quantification. Eur J Echocardiogr 2006;7:79-108.
  • Matsumori A. Hepatitis C virus infection and cardiomyopathies. Circ Res 2005;96:144-7.
  • Matsumori A. Role of hepatitis C virus in cardiomyopathies. Ernst Schering Res Found Workshop 2006:99-120.
  • Demir M, Demir C. Effect of hepatitis B virus infection on right and left ventricular functions. Med Sci Monit. 2012;18: CR587-91.
  • Ishizaka N, Ishizaka Y, Takahashi E, Toda Ei E, Hashimoto H, Ohno M, et al. Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers. Circulation 2002;105:1028-30.
  • Wang L, Geng J, Li J, Li T, Matsumori A, Chang Y, et al. The biomarker N-terminal pro-brain natriuretic peptide and liver diseases. Clin Invest Med 2011;1;34:E30-7.
  • Kucukazman M, Ata N, Yavuz B, Dal K, Ertugrul DT, Yalcin AA, et al. Elevation of B-type natriuretic Peptide level in asymptomatic hepatitis B virus-positive patients is not associated with abnormalities of cardiac function. Med Princ Pract 2012;21:150-5.
  • Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148-56.
  • Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399-404.
  • Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.
There are 23 citations in total.

Details

Primary Language English
Subjects Infectious Diseases
Journal Section Original Articles
Authors

Canan Demir

Mehmet Demir

Publication Date July 4, 2016
Submission Date May 9, 2016
Acceptance Date June 23, 2016
Published in Issue Year 2016 Volume: 2 Issue: 2

Cite

AMA Demir C, Demir M. Mean platelet volume is increased in patients with chronic hepatitis B. Eur Res J. July 2016;2(2):132-136. doi:10.18621/eurj.2016.5000188880

e-ISSN: 2149-3189 


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