Year 2018, Volume 4 , Issue 1, Pages 38 - 43 2018-01-04

Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Ayca ANT [1] , Erdogan INAL [2] , Aslihan AVCİ [3] , Metin GENC [4] , Umit TUNCEL [5] , Ziya SENCAN [6] , Yasemin GENC [7]


Objective. Inflammation and oxidative stress are considered as the main pathways in oral cavity carcinoma. The aim of this study was to evaluate the activity levels of adenosine deaminase (ADA), nitric oxide (NO), nitric oxide synthase (NOS), and xanthine oxidase (XO) in oral cavity carcinoma, to determine their potential roles in carcinogenesis with relation to oxidative stress. Methods. Seventeen patients with oral cavity cancer underwent surgery as the primary therapy, were consisted in the study. Resected oral cavity carcinoma tissues were compared with the adjacent tumor-free control tissues of the same patients; ADA, NO, NOS, XO activity levels were evaluated in terms of difference. Results. There is a significant increase of ADA activity in squamous cell cancer tissues, which indicates a difference between the normal and tumor tissues at enzyme levels (p<0.001). Conclusion. Elevated ADA activity might be an attempt to supress formation of the immunosupressed niche which promotes the onset of neoplasia and/or to inhibit tumor progression and metastasis. 

Adenosine deaminase, nitric oxide, nitric oxide synthase, oral cancer, oxidative stress, xanthine oxidase
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Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0002-9469-1468
Author: Ayca ANT
Institution: Department of Otorhinolaryngology, Ankara Oncology Training and Research Hospital, Ankara
Country: Turkey


Author: Erdogan INAL
Institution: Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara
Country: Turkey


Author: Aslihan AVCİ
Institution: Department of Biochemistry, Ankara University School of Medicine, Ankara
Country: Turkey


Author: Metin GENC
Institution: Department of Biochemistry, Ankara University School of Medicine, Ankara
Country: Turkey


Author: Umit TUNCEL
Institution: Department of Otorhinolaryngology, Ankara Oncology Training and Research Hospital, Ankara
Country: Turkey


Author: Ziya SENCAN
Institution: Department of Otorhinolaryngology, Ankara Oncology Training and Research Hospital, Ankara
Country: Turkey


Author: Yasemin GENC
Institution: Department of Biostatistics, Ankara University School of Medicine, Ankara
Country: Turkey


Dates

Application Date : June 20, 2017
Acceptance Date : August 2, 2017
Publication Date : January 4, 2018

EndNote %0 The European Research Journal Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer %A Ayca Ant , Erdogan Inal , Aslihan Avci , Metin Genc , Umit Tuncel , Ziya Sencan , Yasemin Genc %T Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer %D 2018 %J The European Research Journal %P -2149-3189 %V 4 %N 1 %R doi: 10.18621/eurj.322520 %U 10.18621/eurj.322520