Case Report
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Year 2018, Volume: 4 Issue: 3, 231 - 234, 04.07.2018
https://doi.org/10.18621/eurj.370328

Abstract

References

  • [1] Machado NO. Neutropenic enterocolitis: A continuing medical and surgical challenge. N Am J Med Sci 2010;2:293-300.
  • [2] Takaoka E, Kawai K, Ando S, Shimazui T, Akaza H. Neutropenic colitis during standard dose combinaton chemotherapy with nedaplatin and irinotecan for testicular cancer. Jpn J Clin Oncol 2006;36:60-3.
  • [3] Ramsingh J, Bolln C, Hodnett R, Al-Ani A. Neutropenic enterocolitis affecting the transverse colon: an unusual complication of chemotherapy. BMJ Case Rep 2014;2014:bcr2014204035.
  • [4] Seewaldt V, Cain JM, Greer BE, Tamimi H, Figge DC. Bowel complications with taxol therapy. J Clin Oncol 1993;11:1198.
  • [5] Sodhi KS, AiyappanSK, Singh G, Prakas M, Khandelwal N. Colitis and colonic perforation in a patient with breast carcinoma trated with taxane based chemotherapy. Indian J Cancer 2011;48:134-5.
  • [6] Yapar Taşköylü B, Gökçen Demiray A, Aksoy P, Yaren A, Gököz Doğu G, et al. [Neutropenic enterocolitis after adjuvant chemotherapy: a case report]. Pamukkale Tıp Dergisi 2013;6:96-9. [Article in Turkish]
  • [7] Oehadian A, Fadjari TH. Neutropenic enterocolitis in breast cancer patient after taxane-containinig chemotherapy. Acta Med Indones 2008;40:29-33.
  • [8] Rolston KV. Neutropenic enterocolitis associated with docetaxel therapy in a patient with breast cancer. Clin Adv Hematol Oncol 2009;7:527-8.
  • [9] Cartoni C, Dragoni F, Micozzi A, Pescarmona E, Mecarocci S, Chirletti P, et al. Neutropenic enterocolitis in patients with acute leukemia: Progmostic significance of bowel wall thickening dedected by ultrasonography. J Clin Oncol 2001;19:756-61.
  • [10] Colucci G, Thaler W, Dejaco H, Marsoner H, Grones A. Colonic rupture in a patient on combination chemotherapy for metastasized carcinoma of the esophagogastric junction. Case report and review of the literature. Onkologie 2005;28:204-6.

Neutropenic enterocolitis and colonic perforation in a patient with breast carcinoma treated with taxane-based chemotherapy: a case report and review of the literature

Year 2018, Volume: 4 Issue: 3, 231 - 234, 04.07.2018
https://doi.org/10.18621/eurj.370328

Abstract

Neutropenic enterocolitis or typhlitis is one of the
rare but high mortality acute complications of neutropenia that develops in
immunosuppressed patients due to chemotherapy. It is a segmental cecal and
ascending colon inflammation that can progress to necrosis and perforation.
Although it is mostly observed in myelosupressed and immunosuppressed patients,
like those who have leukemia and lymphoma, it can also be observed in
malignancies treated with myelosupressive chemotherapy. It has been reported
particularly in patients with solid tumors treated with taxane-based chemotherapy.
In this article, a 40-year-old patient with invasive ductal breast carcinoma is
presented, who was diagnosed with neutropenic enterocolitis and colonic
perforation that developed 6 days after chemotherapy (Docetaxel 75 mg/m2
and cyclophosphamide 600 mg/m2). If neutropenic fever, abdominal
pain, abdominal distension, and tenderness develops in a patient under taxane-based chemotherapy, neutropenic enterocolitis is a
condition that must definitely be considered. It should be noted that it is
possible to reduce mortality and morbidity by means of appropriate antibiotics
and a timely surgical intervention.

References

  • [1] Machado NO. Neutropenic enterocolitis: A continuing medical and surgical challenge. N Am J Med Sci 2010;2:293-300.
  • [2] Takaoka E, Kawai K, Ando S, Shimazui T, Akaza H. Neutropenic colitis during standard dose combinaton chemotherapy with nedaplatin and irinotecan for testicular cancer. Jpn J Clin Oncol 2006;36:60-3.
  • [3] Ramsingh J, Bolln C, Hodnett R, Al-Ani A. Neutropenic enterocolitis affecting the transverse colon: an unusual complication of chemotherapy. BMJ Case Rep 2014;2014:bcr2014204035.
  • [4] Seewaldt V, Cain JM, Greer BE, Tamimi H, Figge DC. Bowel complications with taxol therapy. J Clin Oncol 1993;11:1198.
  • [5] Sodhi KS, AiyappanSK, Singh G, Prakas M, Khandelwal N. Colitis and colonic perforation in a patient with breast carcinoma trated with taxane based chemotherapy. Indian J Cancer 2011;48:134-5.
  • [6] Yapar Taşköylü B, Gökçen Demiray A, Aksoy P, Yaren A, Gököz Doğu G, et al. [Neutropenic enterocolitis after adjuvant chemotherapy: a case report]. Pamukkale Tıp Dergisi 2013;6:96-9. [Article in Turkish]
  • [7] Oehadian A, Fadjari TH. Neutropenic enterocolitis in breast cancer patient after taxane-containinig chemotherapy. Acta Med Indones 2008;40:29-33.
  • [8] Rolston KV. Neutropenic enterocolitis associated with docetaxel therapy in a patient with breast cancer. Clin Adv Hematol Oncol 2009;7:527-8.
  • [9] Cartoni C, Dragoni F, Micozzi A, Pescarmona E, Mecarocci S, Chirletti P, et al. Neutropenic enterocolitis in patients with acute leukemia: Progmostic significance of bowel wall thickening dedected by ultrasonography. J Clin Oncol 2001;19:756-61.
  • [10] Colucci G, Thaler W, Dejaco H, Marsoner H, Grones A. Colonic rupture in a patient on combination chemotherapy for metastasized carcinoma of the esophagogastric junction. Case report and review of the literature. Onkologie 2005;28:204-6.
There are 10 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Aslıhan Demirel

Selçuk Kihtir This is me

Gürkan Geceer This is me

Safiye Koçulu This is me

Esin Çevik This is me

Publication Date July 4, 2018
Submission Date December 23, 2017
Acceptance Date December 30, 2017
Published in Issue Year 2018 Volume: 4 Issue: 3

Cite

AMA Demirel A, Kihtir S, Geceer G, Koçulu S, Çevik E. Neutropenic enterocolitis and colonic perforation in a patient with breast carcinoma treated with taxane-based chemotherapy: a case report and review of the literature. Eur Res J. July 2018;4(3):231-234. doi:10.18621/eurj.370328

e-ISSN: 2149-3189 


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