Intrathoracic extramedullary hematopoiesis as a posterior mediastinal tumor: a case report

Year 2018, Volume: 4 Issue: 4, 436 - 438, 04.10.2018

Elçin Ersöz Köse Gökay Reyhan Serda Kanbur Metin Serdar Evman Çağatay Tezel İrfan Yalçınkaya

https://doi.org/10.18621/eurj.345666

Cited By: 1

Abstract

Extramedullary
hematopoiesis (EMH) is a rare disorder, defined as the appearance of
hematopoietic elements outside the bone marrow or peripheral blood. Usually it
is diagnosed incidentally and very rarely it presents as a posterior
mediastinal mass clinically mimicking with many other benign or malignant
mediastinal tumors. Intrathoracic EMH is a rare condition and only very few
case reports have been described in patients with chronic myeloproliferative
disorders specially myelofibrosis with myeloid metaplasia and spherocytic
anemias. The paravertebral area is an uncommon site for EMH, with the possible
exception of sporadically reported intrathoracic manifestations. In this study,
a 38-year-old male patient was followed for myeloproliferative disease.
Tumor-like lesions at the bilateral posterior mediastinum were detected in the
patient who applied to our clinic due to fall. Excision was planned with video-
assisted thoracoscopic surgery to differentiate from mediastinal tumors, but
the mass unblock was removed with posterolateral thoracotomy because of the
appearance of the lesion and large size. Histopathologic diagnosis was reported
as extramedullary hematopoiesis. Patient was presented because of its rare
location. 

Keywords

Extramedullary hematopoiesis, posterior mediastinum, myeloproliferative disease

References

• [1] An J, Weng Y, He J, Li Y, Huang S, Cai S, et al. Intrathoracic extramedullary hematopoiesis presenting as tumor-simulating lesions of the mediastinum in α-thalassemia: a case report. Oncol Lett 2015;10:1993-6.
• [2] Ng CS, Wan S, Lee TW, Sihoe AD, Wan IY, Arifi AA, et al. Video-assisted thoracic surgery for mediastinal extramedullary hematopoiesis. Ann R Coll Surg Engl 2002;84:161-3.
• [3] Özdemir L, Özdemir B, Durkaya S, Topal C, Çalışkan SN, Ersoy A, et al. [A rare cause of posterior mediastinal masses: extramedullary hematopoiesis (two cases)]. Respir Case Rep 2014;3:156-8. [Article in Turkish]
• [4] Paydaş S, Sargın Ö, Gönlüşen G. PET CT imaging in extramedullary hematopoiesis and lung cancer surprise in a case with thalassemia intermedia. Turk J Haematol 2011;28:60-2.
• [5] Zade A, Purandare N, Rangarajan V, Shah S, Agrawal A, Ashish J, et al. Noninvasive approaches to diagnose intrathoracic extramedullary hematopoiesis: 18F-FLT PET/CT and 99mTc-SC SPECT/CT scintigraphy. Clin Nucl Med 2012;37:788-9.
• [6] Yeom SY, Lim JH, Han KN, Kang CH, Park IK, Kim YT. Extramedullary hematopoiesis at the posterior mediastinum in patient with hereditary spherocytosis: A case report. Korean J Thorac Cardiovasc Surg 2013;46:156-8.