Research Article
BibTex RIS Cite
Year 2018, Volume: 4 Issue: 4, 333 - 342, 04.10.2018
https://doi.org/10.18621/eurj.345991

Abstract

References

  • [1] Rosenberg AE, Nielsen GP, Fletcher JA, Kalil RK, Araujo. Aneurysmal bone cyst, Simple bone cyst. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002.
  • [2] Doğanavşargil B, Ayhan E, Argin M, Pehlivanoğlu B, Keçeci B, Sezak M, et al. Cystic bone lesions: histopathological spectrum and diagnostic challenges. Turk Patoloji Derg 2015;31:95-103.
  • [3] Unni KK, Inwards CY. Miscellaneous unusual tumors of bone. In: Dahlin's Bone Tumors. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2010.
  • [4] Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 2004;165:1773-80.
  • [5] Remotti F, Feldman F. Nonneoplastic lesions that simulate primary tumors of bone. Arch Pathol Lab Med 2012;136:772-88.
  • [6] Szuhai K, Cleton-Jansen A, Hogendoom PCW, Bovée JVMG. Molecular pathology and its diagnostic use in bone tumors. Cancer Genet 2012;205:193-204.
  • [7] Unni KK, Inwards CY, Bridge JA, Kindblom L, Wold LE. In: Tumors of The Bones and Joints. AFIP Atlas of Tumor Pathology. Washington, D.C.: American Registry of Pathology, Armed Forces Institute of Pathology, 2005.
  • [8] Mirra JM, Picci P, Gold RH. In: Bone tumors: clinical, radiologic, and pathologic correlation. Philadelphia: Lea & Febiger, 1989.
  • [9] Rapp TB, Ward JP, Alaia MJ. Aneurysmal bone cyst. J Am Acad Orthop Surg 2012;20:233-41.
  • [10] Martinez V, Sissons HA. Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer 1988;61:2291-304.
  • [11] Lee JW, Kim JH, Han SH, Kang HI. Fibrous dysplasia with aneurysmal bone cyst presenting as painful solitary skull lesion. J Korean Neurosurg Soc 2010;48:551-4.
  • [12] Yazici B, Yazici Z, Yalcinkaya U. Aneurysmal bone cyst secondary to ossifying fibroma in the orbit. Ophthal Plast Reconstr Surg 2011;27:84-5.
  • [13] Ozan F, Toker G. Secondary aneurysmal bone cyst of the patella. Acta Orthop Traumatol Turc 2010;44:246-9.
  • [14] Guedes A, Barreto B, Soares Barreto LG, Athanazio DA, Athanazio PR. Calcaneal chondroblastoma with secondary aneurysmal bone cyst: a case report. J Foot Ankle Surg 2010;49:298.e5-8.
  • [15] Sanerkin NG, Mott MG, Roylance J. An unusual intraosseous lesion with fibroblastic, osteoclastic, osteoblastic, aneurysmal and fibromyxoid elements. "Solid" variant of aneurysmal bone cyst. Cancer 1983;51:2278-86.
  • [16] Karampalis C, Lenthall R, Boszczyk B. Solid variant of aneurysmal bone cyst on the cervical spine of a child: case report, differential diagnosis and treatment rationale. Eur Spine J 2013;22:523-31.
  • [17] Gothner M, Citak M, Schildhauer TA, Roetman B. Aneurysmal bone cyst of the spine in an adolescent: a case report. Acta Orthop Belg 2011;77:853-7.
  • [18] Lee HM, Cho KS, Choi KU, Roh HJ. Aggressive aneurysmal bone cyst of the maxilla confused with telangiectatic osteosarcoma. Auris Nasus Larynx 2012;39:337-40.
  • [19] Sangle NA, Layfield LJ. Telangiectatic osteosarcoma. Arch Pathol Lab Med 2012;136:572-6.
  • [20] Mei J, Gao YS, Wang SQ, Cai XS. Malignant transformation of aneurysmal bone cysts: a case report. Chin Med J (Engl) 2009;122:110-2.
  • [21] Brindley GW, Greene JF Jr, Frankel LS. Case reports: malignant transformation of aneurysmal bone cysts. Clin Orthop Relat Res 2005;438:282-7.
  • [22] Cottalorda J, Bourelle S. Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg 2007;127:105-14.
  • [23] Weinman J, Servaes S, Anupindi SA. Treated unicameral bone cysts. Clin Radiol 2013;68:636-42.
  • [24] Baumhoer D, Smida J, Nathrath M, Jundt G. The nature of the characteristic cementum-like matrix deposits in the walls of simple bone cysts. Histopathology 2011;59:390-6.
  • [25] Schajowicz F, Clavel Sainz M, Slullitel JA. Juxta-articular bone cysts (intra-osseous ganglia): a clinicopathological study of eighty-eight cases. J Bone Joint Surg Br 1979;61:107-16.
  • [26] Kural C, Sungur I, Cetinus E. Bilateral lunate intraosseous ganglia. Orthopedics 2010;33:514.
  • [27] Lin JD, Koehler SM, Garcia RA, Qureshi SA, Hecht AC. Intraosseous ganglion cyst within the L4 lamina causing spinal stenosis. Spine J 2012;12:9-12.
  • [29] Gould CF, Ly JQ, Lattin GE Jr, Beall DP, Sutcliffe JB 3rd. Bone tumor mimics: avoiding misdiagnosis. Curr Probl Diagn Radiol 2007;36:124-41.
  • [30] Simon K, Leithner A, Bodo K, Windhager R. Intraosseous epidermoid cysts of the hand skeleton: a series of eight patients. J Hand Surg Eur 2011;36:376-8.
  • [31] Kalfas F, Ramanathan D, Mai J, Schwartz S, Sekhar LN. Petrous bone epidermoid cyst caused by penetrating injury to the external ear: case report and review of literature. Asian J Neurosurg 2012;7:93-7.
  • [32] Nakajo M, Ohkubo K, Nandate T, Nagano Y, Shirahama H, Nakajo M. Intraosseous epidermal cyst of the distal phalanx of the thumb: radiographic and magnetic resonance imaging findings. Radiat Med 2005;23:128-32.
  • [33] Kural C, Ugras AA, Sungur I, Ozturk H, Erturk AH, Unsaldi T. Hydatid bone disease of the femur. Orthopedics 2008;31:712.
  • [34] Guney M, Tekeli H, Kendirli MT, Kaya S, Turhan V, Sonmez G, et al. Intramedullary hydatid cyst of the cervical spine. Indian J Med Microbiol 2012;30:480-1.
  • [35] Ahmad M, Ekramullah, Ahmad I, Ali SA. A rare case of intradural spinal hydatid cyst in a paediatric patient. JBR-BTR 2012;95:87-8.
  • [36] Kapoor SK, Kataria H, Patra SR, Bharadwaj M, Vijay V, Kapoor S. Multi-organ hydatidosis with extensive involvement of the hemi-pelvis and ipsilateral femur. Parasitol Int 2013;62:82-5.

Pathological analysis of cystic lesions of the bones: a retrospective single-center 10-year overview

Year 2018, Volume: 4 Issue: 4, 333 - 342, 04.10.2018
https://doi.org/10.18621/eurj.345991

Abstract

Objective: Many different neoplastic and non-neoplastic
lesions involve the skeletal system. Clinical and radiological tools primarily
assess the nature of these lesions.The aim of
this study was to analyze the cystic bone lesions in a pathologic point
of view.

Methods: All bone cysts between 2002 and 2013 retrospectively evaluated under the guidance of
clinical information and radiological images. Descriptive
data such as age, gender, tumor site, symptoms, and clinical and radiological
findings obtained from the hospital’s database system.

Results:
There were 96 cystic bone lesions; 47
were aneurysmal bone cysts (ABCs), 37 were simple bone cysts (SBCs), one was a
lesion with features of both ABC and SBC, four were intraosseous ganglia, four
were epidermoid cysts, and three were hydatid cysts. The mean ages of the
patients with ABCs and SBCs were 18.7 ±
12.8 years (range, 3-75 years) and 23.8 ±
13.3 years (range, 3-62 years), respectively. Most of the lesions located in
the long bones.

Conclusions: Cystic lesions of the bone rarely encountered in daily pathology routine. As with all
conditions affecting the skeletal system, one of the most important steps
towards an accurate pathological diagnosis is to perform with clinical and radiological information while evaluating
the patients. 

References

  • [1] Rosenberg AE, Nielsen GP, Fletcher JA, Kalil RK, Araujo. Aneurysmal bone cyst, Simple bone cyst. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002.
  • [2] Doğanavşargil B, Ayhan E, Argin M, Pehlivanoğlu B, Keçeci B, Sezak M, et al. Cystic bone lesions: histopathological spectrum and diagnostic challenges. Turk Patoloji Derg 2015;31:95-103.
  • [3] Unni KK, Inwards CY. Miscellaneous unusual tumors of bone. In: Dahlin's Bone Tumors. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2010.
  • [4] Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 2004;165:1773-80.
  • [5] Remotti F, Feldman F. Nonneoplastic lesions that simulate primary tumors of bone. Arch Pathol Lab Med 2012;136:772-88.
  • [6] Szuhai K, Cleton-Jansen A, Hogendoom PCW, Bovée JVMG. Molecular pathology and its diagnostic use in bone tumors. Cancer Genet 2012;205:193-204.
  • [7] Unni KK, Inwards CY, Bridge JA, Kindblom L, Wold LE. In: Tumors of The Bones and Joints. AFIP Atlas of Tumor Pathology. Washington, D.C.: American Registry of Pathology, Armed Forces Institute of Pathology, 2005.
  • [8] Mirra JM, Picci P, Gold RH. In: Bone tumors: clinical, radiologic, and pathologic correlation. Philadelphia: Lea & Febiger, 1989.
  • [9] Rapp TB, Ward JP, Alaia MJ. Aneurysmal bone cyst. J Am Acad Orthop Surg 2012;20:233-41.
  • [10] Martinez V, Sissons HA. Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer 1988;61:2291-304.
  • [11] Lee JW, Kim JH, Han SH, Kang HI. Fibrous dysplasia with aneurysmal bone cyst presenting as painful solitary skull lesion. J Korean Neurosurg Soc 2010;48:551-4.
  • [12] Yazici B, Yazici Z, Yalcinkaya U. Aneurysmal bone cyst secondary to ossifying fibroma in the orbit. Ophthal Plast Reconstr Surg 2011;27:84-5.
  • [13] Ozan F, Toker G. Secondary aneurysmal bone cyst of the patella. Acta Orthop Traumatol Turc 2010;44:246-9.
  • [14] Guedes A, Barreto B, Soares Barreto LG, Athanazio DA, Athanazio PR. Calcaneal chondroblastoma with secondary aneurysmal bone cyst: a case report. J Foot Ankle Surg 2010;49:298.e5-8.
  • [15] Sanerkin NG, Mott MG, Roylance J. An unusual intraosseous lesion with fibroblastic, osteoclastic, osteoblastic, aneurysmal and fibromyxoid elements. "Solid" variant of aneurysmal bone cyst. Cancer 1983;51:2278-86.
  • [16] Karampalis C, Lenthall R, Boszczyk B. Solid variant of aneurysmal bone cyst on the cervical spine of a child: case report, differential diagnosis and treatment rationale. Eur Spine J 2013;22:523-31.
  • [17] Gothner M, Citak M, Schildhauer TA, Roetman B. Aneurysmal bone cyst of the spine in an adolescent: a case report. Acta Orthop Belg 2011;77:853-7.
  • [18] Lee HM, Cho KS, Choi KU, Roh HJ. Aggressive aneurysmal bone cyst of the maxilla confused with telangiectatic osteosarcoma. Auris Nasus Larynx 2012;39:337-40.
  • [19] Sangle NA, Layfield LJ. Telangiectatic osteosarcoma. Arch Pathol Lab Med 2012;136:572-6.
  • [20] Mei J, Gao YS, Wang SQ, Cai XS. Malignant transformation of aneurysmal bone cysts: a case report. Chin Med J (Engl) 2009;122:110-2.
  • [21] Brindley GW, Greene JF Jr, Frankel LS. Case reports: malignant transformation of aneurysmal bone cysts. Clin Orthop Relat Res 2005;438:282-7.
  • [22] Cottalorda J, Bourelle S. Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg 2007;127:105-14.
  • [23] Weinman J, Servaes S, Anupindi SA. Treated unicameral bone cysts. Clin Radiol 2013;68:636-42.
  • [24] Baumhoer D, Smida J, Nathrath M, Jundt G. The nature of the characteristic cementum-like matrix deposits in the walls of simple bone cysts. Histopathology 2011;59:390-6.
  • [25] Schajowicz F, Clavel Sainz M, Slullitel JA. Juxta-articular bone cysts (intra-osseous ganglia): a clinicopathological study of eighty-eight cases. J Bone Joint Surg Br 1979;61:107-16.
  • [26] Kural C, Sungur I, Cetinus E. Bilateral lunate intraosseous ganglia. Orthopedics 2010;33:514.
  • [27] Lin JD, Koehler SM, Garcia RA, Qureshi SA, Hecht AC. Intraosseous ganglion cyst within the L4 lamina causing spinal stenosis. Spine J 2012;12:9-12.
  • [29] Gould CF, Ly JQ, Lattin GE Jr, Beall DP, Sutcliffe JB 3rd. Bone tumor mimics: avoiding misdiagnosis. Curr Probl Diagn Radiol 2007;36:124-41.
  • [30] Simon K, Leithner A, Bodo K, Windhager R. Intraosseous epidermoid cysts of the hand skeleton: a series of eight patients. J Hand Surg Eur 2011;36:376-8.
  • [31] Kalfas F, Ramanathan D, Mai J, Schwartz S, Sekhar LN. Petrous bone epidermoid cyst caused by penetrating injury to the external ear: case report and review of literature. Asian J Neurosurg 2012;7:93-7.
  • [32] Nakajo M, Ohkubo K, Nandate T, Nagano Y, Shirahama H, Nakajo M. Intraosseous epidermal cyst of the distal phalanx of the thumb: radiographic and magnetic resonance imaging findings. Radiat Med 2005;23:128-32.
  • [33] Kural C, Ugras AA, Sungur I, Ozturk H, Erturk AH, Unsaldi T. Hydatid bone disease of the femur. Orthopedics 2008;31:712.
  • [34] Guney M, Tekeli H, Kendirli MT, Kaya S, Turhan V, Sonmez G, et al. Intramedullary hydatid cyst of the cervical spine. Indian J Med Microbiol 2012;30:480-1.
  • [35] Ahmad M, Ekramullah, Ahmad I, Ali SA. A rare case of intradural spinal hydatid cyst in a paediatric patient. JBR-BTR 2012;95:87-8.
  • [36] Kapoor SK, Kataria H, Patra SR, Bharadwaj M, Vijay V, Kapoor S. Multi-organ hydatidosis with extensive involvement of the hemi-pelvis and ipsilateral femur. Parasitol Int 2013;62:82-5.
There are 35 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Gonca Özgün 0000-0002-2710-127X

Ulviye Yalçınkaya

Zeynep Yazıcı

Bartu Sarısözen 0000-0003-4071-8052

Publication Date October 4, 2018
Submission Date October 23, 2017
Acceptance Date January 25, 2018
Published in Issue Year 2018 Volume: 4 Issue: 4

Cite

AMA Özgün G, Yalçınkaya U, Yazıcı Z, Sarısözen B. Pathological analysis of cystic lesions of the bones: a retrospective single-center 10-year overview. Eur Res J. October 2018;4(4):333-342. doi:10.18621/eurj.345991

e-ISSN: 2149-3189 


The European Research Journal, hosted by Turkish JournalPark ACADEMIC, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

by-nc-nd.png

2024