Year 2018, Volume 4 , Issue 4, Pages 349 - 355 2018-10-04

Liver functions in patients with obstructive sleep apnea syndrome

Seda Beyhan Sağmen [1] , Elif Torun Parmaksız [2] , Sevda Şener Cömert [3] , Ali Fidan [4] , Banu Salepçi [5]


Objective: Previous studies showed that obstructive sleep apnea syndrome (OSAS) was associated with liver diseases such as elevated liver enzyme levels and hepatic steatosis. The aim of this study was to assess the relationship between serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and OSAS and its severity.

Methods: A total of 617 patients who underwent PSG (polysomnography) between January 2016 and May 2017 were evaluated in this study. AST, ALT, total cholesterol, triglyceride levels and body mass index were analyzed. The data were analyzed using the Student t-test, ANOVA, Chi-square test, and Pearson's correlation coefficient.

Results: Five hundreds and thirty patients with OSAS and 60 healthy controls were included in the study. Of the patients in the OSAS group, 17.7% had an elevated ALT level and 7.9% had an elevated AST level. There was a statistically significant difference in ALT and AST levels between the OSAS and control groups (p < 0.001 and p < 0.001, respectively). In the OSAS group, there was a statistically significant positive relationship between serum ALT and AST levels and apnea-hypopnea index (AHI), apnea index, oxygen desaturation index. Both AST and ALT levels were statistically significantly higher in obese patients than in non-obese patients (p < 0.001 and p < 0.001, respectively). ALT level was statistically significantly higher in patients without hypertension than in patients with hypertension (p < 0.001). In OSAS patients without hypertension, there was a statistically significant relationship between serum ALT and AST levels and AHI (r = 0.223, p < 0.001 and r = 0.142, p = 0.007; respectively).

Conclusion: OSAS is a risk factor for elevated liver enzyme levels. Hypoxia plays an important role on liver enzymes in OSAS patients. 

liver enzymes, obstructive sleep apnea syndrome, hypertension
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0002-1632-2966
Author: Seda Beyhan Sağmen (Primary Author)
Institution: UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF THORACIC DISEASES
Country: Turkey


Orcid: 0000-0003-2256-4838
Author: Elif Torun Parmaksız
Institution: UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF THORACIC DISEASES
Country: Turkey


Orcid: 0000-0002-8124-9304
Author: Sevda Şener Cömert
Institution: UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF THORACIC DISEASES
Country: Turkey


Orcid: 0000-0003-3449-6916
Author: Ali Fidan
Institution: UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF THORACIC DISEASES
Country: Turkey


Orcid: 0000-0003-1217-019X
Author: Banu Salepçi
Institution: YEDITEPE UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF THORACIC DISEASES
Country: Turkey


Dates

Publication Date : October 4, 2018

EndNote %0 The European Research Journal Liver functions in patients with obstructive sleep apnea syndrome %A Seda Beyhan Sağmen , Elif Torun Parmaksız , Sevda Şener Cömert , Ali Fidan , Banu Salepçi %T Liver functions in patients with obstructive sleep apnea syndrome %D 2018 %J The European Research Journal %P -2149-3189 %V 4 %N 4 %R doi: 10.18621/eurj.381906 %U 10.18621/eurj.381906