The association of carotid intima-media thickness with body mass index and cortisol level in fibromyalgia syndrome

Year 2019, Volume: 5 Issue: 1, 83 - 87, 04.01.2019

Tuba Tülay Koca , Ayla Çimen

https://doi.org/10.18621/eurj.376343

Cited By: 3

Abstract

Objectives: Patients with fibromyalgia
syndrome (FMS) may have the risk for atherosclerotic disease because of chronic
stress, disrupted neuroendocrine axis, high BMI and inflammation. This is study
aimed to research the stress and the stress-related diseases in patients with
FMS by measuring obesity, morning serum cortisol level, and carotid
intima-media thickness (CIMT), which is the early indicator of the
atherosclerosis.

Methods: This case-control study included 57 patients who were
diagnosed with FMS according to 2010 American
College of Rheumatology (ACR) Criteria
and visited the outpatient clinic in February 2016. As a control group, 36
healthy females who visited the outpatient clinic in the same month were
included. Carotid intima-media thickness and cortisol levels were analysed.

Results: The present study included 93 females between 15 and 79 years old. The mean
age of the 57 females with FMS and 37 healthy females was 44.5 ±
10.6 years and 47.9 ± 18.5 years, respectively (p = 0.260). The mean CIMT value of the
FMS and control groups was 0.64 ± 0.17 mm and 0.59 ± 0.16 mm, respectively (p = 0.170). The morning blood cortisol
level in the FMS and control groups was 7.8 ± 3.3 ng/dL and 8.7 ± 2.8 ng/dL,
respectively (p = 0.460). The CIMT
and morning blood cortisol level were not correlated in the FMS group.

Conclusion: According to the present study, CIMT value and
morning blood cortisol level were not found significantly different in FMS
group, and also were not  found
correlated with each other. 

Keywords

Atherosclerosis, carotid intima-media thickness, fibromyalgia syndrome

References

• [1] de Groot E, van Leuven SI, Duivenvoorden R, Meuwese MC, Akdim F, Bots ML, et al. Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis. Nat Clin Pract Cardiovasc Med 2008;5:280-8.
• [2] Costanzo P, Perrone-Filardi P, Vassallo E, Paolillo S, Cesarano P, Brevetti G, et al. Does carotid intima-media thickness regression predict reduction of cardiovascular events? A meta-analysis of 41 randomized trials. J Am Coll Cardiol 2010;56:2006-20.
• [3] Sharma K, Blaha MJ, Blumenthal RS, Musunuru K. Clinical and research applications of carotid intima-media thickness. Am J Cardiol 2009;103:1316-20.
• [4] Riva R, Mork PJ, Westgaard RH, Rø M, Lundberg U. Fibromyalgia syndrome is associated with hypocortisolism. Int J Behav Med 2010;17:223-33.
• [5] Semiz EA, Hizmetli S, Semiz M, Karadağ A, Adalı M, Tuncay MS, et al. Serum cortisol and dehydroepiandrosterone-sulfate levels after balneotherapy and physical therapy in patients with fibromyalgia. Saudi Med J 2016;37:544-50.
• [6] Rossi A, Di Lollo AC, Guzzo MP, Giacomelli C, Atzeni F, Bazzichi L, et al. Fibromyalgia and nutrition: what news? Clin Exp Rheumatol 2015;33(1 Suppl 88):S117-25.
• [7] Koca TT, Tanrıkut E, Acet G, Talu B. Evaluation of sleep disorder and its effect on sexual dysfunction in patients with fibromyalgia syndrome. Turk J Obstet Gynecol 2016;13:167-71.
• [8] Sarzi-Puttini P, Atzeni F, Masala IF, Salaffi F, Chapman J, Choy E. Are the ACR 2010 diagnostic criteria for fibromyalgia better than the 1990 criteria? Autoimmun Rev 2018;17:33-35.
• [9] Pignoli P. Ultrasound B-mode imaging for arterial wall thickness measurement. Atherosclerosis Rev 1984;12:177-84.
• [10] Riedel W, Layka H, Neeck G. Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Z Rheumatol 1998;57:81-7.
• [11] Fatima G, Das SK, Mahdi AA, Verma NS, Khan FH, Tiwari AM, et al. Circadian rhythm of serum cortisol in female patients with fibromyalgia syndrome. Indian J Clin Biochem 2013;28:181-4.
• [12] Yeung EW, Davis MC, Ciaramitaro MC. Cortisol profile mediates the relation between childhood neglect and pain and emotional symptoms among patients with fibromyalgia. Ann Behav Med 2016;50:87-97.
• [13] Rus A, Molina F, Gassó M, Camacho MV, Peinado MÁ, Moral ML. Nitric oxide, inflammation, lipid profile, and cortisol in normal- and overweight women with fibromyalgia. Biol Res Nurs 2016;18:138-46.
• [14] Önal ZE, Soydan L, Öztürk HE, Sağ Ç, Gürbüz T, Nuhoğlu Ç, et al. Carotid intima media thickness in obese children: is there an association with hyperlipidemia? J Pediatr Endocrinol Metab 2016;29:157-62.
• [15] Eller NH, Netterstrøm B, Hansen AM. Cortisol in urine and saliva: relations to the intima media thickness, IMT. Atherosclerosis 2001;159:175-85.
• [16] Eller NH, Netterstrøm B, Allerup P. Progression in intima media thickness--the significance of hormonal biomarkers of chronic stress. Psychoneuroendocrinology 2005;30:715-23.
• [17] Tseng CH, Chen JH, Wang YC, Lin MC, Kao CH. Increased risk of stroke in patients with fibromyalgia: a population-based cohort study. Medicine (Baltimore) 2016;95:e2860.
• [17] Tseng CH, Chen JH, Wang YC, Lin MC, Kao CH. Increased risk of stroke in patients with fibromyalgia: a population-based cohort study. Medicine (Baltimore) 2016;95:e2860.
• [18] Koca TT. Does obesity cause chronic inflammation? The association between complete blood parameters with body mass index and fasting glucose. Pak J Med Sci 2017;33:65-9.
• [19] Tulay KT, Emrullah T, Aydin A, Ciledag OF. The effect of fibromyalgia syndrome to gravidity, parity and duration of breastfeeding; A prospective study from Turkey. Pak J Med Sci 2016;32:545-9.