Review
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Year 2019, Volume: 5 Issue: 1, 166 - 173, 04.01.2019
https://doi.org/10.18621/eurj.411682

Abstract

References

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Coenzyme Q10 deficiency in elderly: Can nutritional supplementation play a role? Mini review

Year 2019, Volume: 5 Issue: 1, 166 - 173, 04.01.2019
https://doi.org/10.18621/eurj.411682

Abstract

Coenzyme
Q10 (CoQ10), an important mitochondrial redox component, plays a pivotal role
in cellular energy production; moreover, it is the only lipid-soluble
antioxidant endogenously synthesized in humans. Given its function and physiological
importance, it is not surprising that CoQ10 deficiency may result in several
diseases. With aging, humans begin to lose the ability to synthesize CoQ10 from
food, resulting in reduced serum levels
of CoQ10 and contributing to aging-associated symptoms. Poor eating habits,
infections, stress and also some drugs, as beta blockers,
antihypertensive agents and statns,
may reduce serum levels
of CoQ10. Dietary supplementation has been proposed as key strategy to increase
CoQ10 availability, improving health status in elderly; however CoQ10 is not
approved by U.S. Food and Drug Administration for the treatment of any medical
condition and it is sold only as a dietary supplement. Aim of the study was to
examine the latest relevant evidences on potential benefits of CoQ10 nutritional
supplement and its implication in improving health status in elderly. There is
evidence that, in elderly, oral administration of CoQ10 reduces oxidative
stress and inflammatory markers and reduces cardiovascular mortality; in
diabetics CoQ10 treatment improves insulin sensitivity and decreases glycated
hemoglobin. Therapeutic benefit from CoQ10 supplementation has also been
obtained in neurodegenerative diseases as Parkinson’s, Alzheimer’s and
Huntington's diseases. CoQ10 supplements could be useful in several aging-
related clinical conditions; however, well standardized long-term and larger
further studies are needed. 

References

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  • [2] Kawamukai M. Biosynthesis of coenzyme Q in eukaryotes. Biosci Biotechnol Biochem 2016;80:23-33.
  • [3] Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24:579-84.
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  • [6] Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Fernández Vega A, de la Mata M, Delgado Pavón A, et al. Coenzyme q10 therapy. Mol Syndromol 2014;5:187-97.
  • [7] Braillon A. Coenzyme Q10 and statin-induced myopathy--II. Mayo Clinic Proc 2015;90:420.
  • [8] Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strategies. Critical Rev Food Sc iNutr 2010;50:269-80.
  • [9] Žmitek K, Pogačnik T, Mervic L, Žmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 on skin parameters and condition: results of a randomised, placebo-controlled, double-blind study. Biofactors 2017;43:132-40.
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There are 94 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Reviews
Authors

Angelo Michele Carella 0000-0003-4825-9620

Teresa Marinelli This is me 0000-0002-6132-3183

Michele Di Pumpo This is me 0000-0001-7626-4879

Giovanni Modola This is me 0000-0001-6236-7922

Angelo Benvenuto This is me 0000-0001-5964-4706

Publication Date January 4, 2019
Submission Date April 1, 2018
Acceptance Date May 2, 2018
Published in Issue Year 2019 Volume: 5 Issue: 1

Cite

AMA Carella AM, Marinelli T, Di Pumpo M, Modola G, Benvenuto A. Coenzyme Q10 deficiency in elderly: Can nutritional supplementation play a role? Mini review. Eur Res J. January 2019;5(1):166-173. doi:10.18621/eurj.411682

e-ISSN: 2149-3189 


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