Research Article
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Year 2019, Volume: 5 Issue: 2, 268 - 273, 04.03.2019
https://doi.org/10.18621/eurj.368447

Abstract

References

  • [1] Yersal O, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol 2014;5:412-2.
  • [2] National Comprehensive Cancer Network. Breast Cancer (Version 3.2017). Avaible from https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf.
  • [3] Nicolini A, Ferrari P, Duffy MJ. Prognostic and predictive biomarkers in breast cancer: past, present and future. Semin Cancer Biol 2017. doi: 10.1016/j.semcancer.2017.08.010.
  • [4] Kawai M, Minami Y, Kuriyama S, Kakizaki M, Kakugawa Y, Nishino Y, et al. Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study. Br J Cancer 2010;103:1443-7.
  • [5] Li CI, Malone KE, Daling JR, Potter JD, Bernstein L, Marchbanks PA, et al. Timing of menarche and first full-term birth in relation to breast cancer risk. Am J Epidemiol 2008;167:230-9.
  • [6] Rockhill B, Spiegelman D, Byrne C, Hunter DJ, Colditz GA. Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention. J Natl Cancer Inst 2001;93:358-66.
  • [7] Zhang SM, Lee IM, Manson JE, Cook NR, Willett WC, Buring JE. Alcohol consumption and breast cancer risk in the Women's Health Study. Am J Epidemiol 2007;165:667-76.
  • [8] Islam T, Matsuo K, Ito H, Hosono S, Watanabe M, Iwata H, et al. Reproductive and hormonal risk factors for luminal, HER2-overexpressing, and triple-negative breast cancer in Japanese women. Ann Oncol 2012;23:2435-41.
  • [9] Hartmann LC, Radisky DC, Frost MH, Santen RJ, Vierkant RA, Benetti LL, et al. Understanding the premalignant potential of atypical hyperplasia through its natural history: a longitudinal cohort study. Cancer Prev Res (Phila) 2014;7:211-7.
  • [10] Shien T, Kinoshita T, Seki K, Yoshida M, Hojo T, Shimizu C, et al. p53 expression in pretreatment specimen predicts response to neoadjuvant chemotherapy including anthracycline and taxane in patients with primary breast cancer. Acta Med Okayama 2013;67:165-70.
  • [11] Karatas F, Sahin S, Erdem GU, Ates O, Babacan T, Akin Set al. Left laterality is an independent prognostic factor for metastasis in N3 stage breast cancer. J BUON. 2016;21:851-8.
  • [12] Rosen PP, Groshen S, Kinne DW, Norton L. Factors influencing prognosis in node-negative breast carcinoma: analysis of 767 T1N0M0/T2N0M0 patients with long-term follow-up. J Clin Oncol 1993;11:2090-100.
  • [13] Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer 1989;63:181-7.
  • [14] Dings PJ, Elferink MA, Strobbe LJ, de Wilt JH. The prognostic value of lymph node ratio in node-positive breast cancer: a Dutch nationwide population-based study. Ann Surg Oncol 2013;20:2607-14.
  • [15] Nabholtz JM1, Gligorov J. The role of taxanes in the treatment of breast cancer. Expert Opin Pharmacother 2005;6:1073-94.

Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival

Year 2019, Volume: 5 Issue: 2, 268 - 273, 04.03.2019
https://doi.org/10.18621/eurj.368447

Abstract

Objectives: The aim of this study was to analyze high risk breast cancer patients with
involvement of five or more axillary lymph nodes with an overall survival of at
least five years, and to determine the predictive and prognostic factors by
comparing patients by recurrence/metastases status retrospectively.

Methods: From a total of 500 patients those were followed up in Adnan Menderes University,
Medical Oncology department, 37 were eligible for the study; 23 were disease
free and 14 had recurrence/metastases in the follow up period. The patients
were analyzed, for demographical (such as age, menopausal status, obesity),
anatomical and histological characteristics of tumor (primary tumor’s diameter,
stage, grade, Ki-67, hormon receptors and Her-2 status), treatment modalities
and prognosis.

Results: Both number of metastatic lymph nodes and
(metastatic/sampled) lymph node ratio were not significantly different between
the recurrence-free and metastatic patients. In the recurrence-free patients
both grade 3 (48% vs none, p = 0.03)
and p53 negative tumors (64% vs 36%, p
= 0.036) were significantly more than metastatic patients. Also in the recurrence
free patients as compared to metastatic patients, adjuvant chemotherapy was applied
more than 6 cycles (87% vs 43%, p = 0.004),
the regimens included more taxane based regimens (91% vs 64%, p = 0.042), aromatase inhibitors were
used higher (100% vs 75%, p = 0.019)
and the period of tamoxifen treatment in switch regimens were shorter.

Conclusion: The results of this study suggested that, high risk breast cancer patients with
involvement of five and more nodes that have the predictive factors as grade 3 and/or
p53 negative tumors are propably more responsive to adjuvant treatments. Chemotherapy
of more than 6 cycles, administering taxane based regimens and aromatase inhibitors
in the adjuvant regimens may favourably effect the prognosis.

References

  • [1] Yersal O, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol 2014;5:412-2.
  • [2] National Comprehensive Cancer Network. Breast Cancer (Version 3.2017). Avaible from https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf.
  • [3] Nicolini A, Ferrari P, Duffy MJ. Prognostic and predictive biomarkers in breast cancer: past, present and future. Semin Cancer Biol 2017. doi: 10.1016/j.semcancer.2017.08.010.
  • [4] Kawai M, Minami Y, Kuriyama S, Kakizaki M, Kakugawa Y, Nishino Y, et al. Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study. Br J Cancer 2010;103:1443-7.
  • [5] Li CI, Malone KE, Daling JR, Potter JD, Bernstein L, Marchbanks PA, et al. Timing of menarche and first full-term birth in relation to breast cancer risk. Am J Epidemiol 2008;167:230-9.
  • [6] Rockhill B, Spiegelman D, Byrne C, Hunter DJ, Colditz GA. Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention. J Natl Cancer Inst 2001;93:358-66.
  • [7] Zhang SM, Lee IM, Manson JE, Cook NR, Willett WC, Buring JE. Alcohol consumption and breast cancer risk in the Women's Health Study. Am J Epidemiol 2007;165:667-76.
  • [8] Islam T, Matsuo K, Ito H, Hosono S, Watanabe M, Iwata H, et al. Reproductive and hormonal risk factors for luminal, HER2-overexpressing, and triple-negative breast cancer in Japanese women. Ann Oncol 2012;23:2435-41.
  • [9] Hartmann LC, Radisky DC, Frost MH, Santen RJ, Vierkant RA, Benetti LL, et al. Understanding the premalignant potential of atypical hyperplasia through its natural history: a longitudinal cohort study. Cancer Prev Res (Phila) 2014;7:211-7.
  • [10] Shien T, Kinoshita T, Seki K, Yoshida M, Hojo T, Shimizu C, et al. p53 expression in pretreatment specimen predicts response to neoadjuvant chemotherapy including anthracycline and taxane in patients with primary breast cancer. Acta Med Okayama 2013;67:165-70.
  • [11] Karatas F, Sahin S, Erdem GU, Ates O, Babacan T, Akin Set al. Left laterality is an independent prognostic factor for metastasis in N3 stage breast cancer. J BUON. 2016;21:851-8.
  • [12] Rosen PP, Groshen S, Kinne DW, Norton L. Factors influencing prognosis in node-negative breast carcinoma: analysis of 767 T1N0M0/T2N0M0 patients with long-term follow-up. J Clin Oncol 1993;11:2090-100.
  • [13] Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer 1989;63:181-7.
  • [14] Dings PJ, Elferink MA, Strobbe LJ, de Wilt JH. The prognostic value of lymph node ratio in node-positive breast cancer: a Dutch nationwide population-based study. Ann Surg Oncol 2013;20:2607-14.
  • [15] Nabholtz JM1, Gligorov J. The role of taxanes in the treatment of breast cancer. Expert Opin Pharmacother 2005;6:1073-94.
There are 15 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Özlem Yersal 0000-0001-8220-4223

Mehmet Yiğit This is me 0000-0002-7359-2137

Nezih Meydan This is me 0000-0003-4100-5804

Sabri Barutca This is me 0000-0002-1941-0531

Publication Date March 4, 2019
Submission Date December 18, 2017
Acceptance Date March 12, 2018
Published in Issue Year 2019 Volume: 5 Issue: 2

Cite

AMA Yersal Ö, Yiğit M, Meydan N, Barutca S. Retrospective evaluation of breast cancer patients with five or more axillary lymph node involvement achieving 5-year overall survival. Eur Res J. March 2019;5(2):268-273. doi:10.18621/eurj.368447

e-ISSN: 2149-3189 


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