Research Article
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Year 2019, Volume: 5 Issue: 2, 250 - 257, 04.03.2019
https://doi.org/10.18621/eurj.425178

Abstract

References

  • [1] Fabbri LM, Hurd SS. GOLD Scientific Committee. Global strategy for the diagnosis, management and prevention of COPD: 2003 update. Eur Respir J 2003;22:1-2.
  • [2] Sengoren Dikis O, Us Dulger S, Karadag M, Demirci H. COPD cases detected by spirometry on world COPD day event in Bursa. Eur Res J 2015;1:61-5.
  • [3] Yoo CG. Pathogenesis and pathophysiology of COPD. Korean J Med 2009;77:383-400.
  • [4] Inonu H, Canbakan S, Capan N, Berktas B, Erturk A, Gulhan M. [Plasma fibrinogen and serum C-reactive protein levels in acute exacerbations and stable period of chronic obstructive pulmonary disease]. Solunum Hastalıkları Dergisi 2006;17:1-7. [Article in Turkish]
  • [5] Saugstad O. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatrica 1996;85:1-4.
  • [6] Ozcan O, Erdal H, Cakirca G, Yonden Z. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exper Invest 2015;6:331-6.
  • [7] Mccord JM. Human disease, free radicals, and the oxidant/antioxidant balance. Clin Biochem 1993;26:351-7.
  • [8] Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32.
  • [9] Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Rad Biol Med 2013;65:244-53.
  • [10] Hu ML. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 1994;233:380-5.
  • [11] Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Rad Biol Med 2010;48:749-62.
  • [12] Abuja PM, Albertini R. Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins. Clin Chim Acta 2001;306:1-17.
  • [13] Ustundag Y, Huysal K, Kahvecioglu S, Demirci H, Yavuz S, Sambel M, et al. Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates. Eur Res J 2016;2:126-31.
  • [14] Eren Y, Dirik E, Neşelioğlu S, Erel Ö. Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study. Acta Neurol Belgi 2015;115:643-9.
  • [15] Kundi H, Ates I, Kiziltunc E, Cetin M, Cicekcioglu H, Neselioglu S, et al. A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis. Am J Emerg Med 2015;33:1567-71.
  • [16] Akbas A, Kilinc F, Sener S, Aktas A, Baran P, Ergin M. Investigation of thiol-disulphide balance in patients with acute urticaria and chronic spontaneous urticaria. Cutan Ocul Toxicol 2017;36:205-10.
  • [17] Dinc ME, Ozdemir C, Ayan NN, Bozan N, Ulusoy S, Koca C, et al. Thiol/disulfide homeostasis as a novel indicator of oxidative stress in obstructive sleep apnea patients. J Laryngol 2017;130:447-52.
  • [18] Ulusoy S, Ayan NN, Dinc ME, Bicer C, Erel O. A new oxidative stress marker for thiol-disulphide homeostasis in seasonal allergic rhinitis. Am J Rhinol Allergy 2016;22:86-92.
  • [19] Gümüşyayla Ş, Vural G, Bektaş H, Neşelioğlu S, Deniz O, Erel Ö. Evaluation of dynamic thiol-disulphide homeostasis in patients with epilepsy. Epilepsia 2016;22:86-92.
  • [46] Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A, Singh SK, et al. Evaluation of oxidative stress and antioxidant status in chronic obstructive pulmonary disease. Scand J Immunol 2017;85:130-7.
  • [47] Ataş H, Kocabıyık M, Gönül M, Öztürk Y, Kavutçu M. Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo. Biomark Med 2017;11:439-49.
  • [20] Ozyazici S, Karateke F, Turan U, Kuvvetli A, Kilavuz H, Karakaya B, et al. A novel oxidative stress mediator in acute appendicitis: thiol/disulphide homeostasis. Mediators Inflamm 2016;2016:6761050.
  • [21] Ates I, Ozkayar N, Inan B, Yilmaz FM, Topcuoglu C, Neselioglu S, et al. Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension. J Am Soc Hyperten 2016;10:159-66.
  • [22] Ozler S, Erel O, Oztas E, Ersoy AO, Ergin M, Sucak A, et al. Serum thiol/disulphide homeostasis in preeclampsia. Hyperten Preg 2015;34:474-85.
  • [23] Lippi G, Montagnana M. Ischemia-modified albumin in ischemic disorders. Ann Thorac Cardiovasc Surg 2009;15:137.
  • [24] Eroglu O, Turkmen S, Mentese A, Altun G, Turedi S, Eryigit U, et al. The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology. Turk J Med Sci 2014;44:62-7.
  • [25] Gunduz A, Turedi S, Mentese A, Altunayoglu V, Turan I, Karahan SC, et al. Ischemia-modified albumin levels in cerebrovascular accidents. Am J Emerg Med 2008;26:874-8.
  • [26] Gunduz A, Turedi S, Mentese A, Karahan SC, Hos G, Tatlı O, et al. Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study. Am J Emerg Med 2008;26:202-5.
  • [27] Turedi S, Gunduz A, Mentese A, Karahan SC, Yilmaz SE, Eroglu O, et al. Value of ischemia-modified albumin in the diagnosis of pulmonary embolism. Am J Emerg Med 2007;25:770-3.
  • [28] Gulpamuk B, Tekin K, Sonmez K, Inanc M, Neselioglu S, Erel O, et al. The significance of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in patients with different stages of diabetes mellitus. Scand J Clin Lab Inv 2018;78:136-42.
  • [29] Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia: a preliminary report. J Emerg Med 2000;19:311-5.
  • [30] Umut S. KOAH patogenezinde oksidatif stress. KOAH seminer notları. In: Umut S, edition. Küre Basım: İstanbul, 1997.
  • [31] Cochrane CG. Cellular injury by oxidants. Am J Med 1991;91:23-30.
  • [32] Orhan Z, Köksal N, Gökırmak M, Hacıevliyagil S, Hasanoğlu C, Mehmet N, et al. [Oxidative stress in acute exacerbations of COPD and the effect of therapy on oxidant-antioxidant balance]. Solunum Hastalıkları Dergisi 2003;14:5-10. [Article in Turkish]
  • [33] Ergin M, Cendek B, Neselioglu S, Avsar A, Erel O. Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum. J Perinatol 2015;35:788-92.
  • [34] Kilinc F, Sener S, Akbas A, Neselioglu S, Erel O, Aktas A. Investigation of dynamic thiol-disulfide homeostasis in alopecia areata patients. Br J Med Med Res 2017;21:1-7.
  • [35] Yilmaz OH, Bal C, Neselioglu S, Buyuksekerci M, Gunduzoz M, Eren F, et al. Thiol/disulfide homeostasis in asphalt workers. Arch Envir Occup Health 2016;71:268-72.
  • [36] Babaoglu E, Kilic H, Hezer H, Dag O, Parlak E, Senturk A, et al. Comparison of thiol/disulphide homeostasis parameters in patients with COPD, asthma and ACOS. Eur Rev Med Pharmacol Sci 2016;20:1537-43.
  • [37] Taşkın D, Önderci M, Yalın S, Fakıoğlu F, Çömelekoğlu U, Yılmaz S, et al. [Antioxidant enzyme activities in patients with COPD admitted to hospitals in Adiyaman]. Adıyaman Univ Sağlık Bilim Derg 2015;1:25-38. [Article in Turkish]
  • [38] Başyiğit İ. KOAH patogenezi ve fizyopatolojisi. TTD Toraks Cerrahisi Bülteni 2010;1:114-8.
  • [39] Şahin Ü, Ünlü M, Sütçü R, Delibaş N, Akkaya A. [The effect of treatment of exacerbations of chronic obstructive pulmonary disease on oxidant/antioxidant imbalance]. Tüberküloz ve Toraks Dergisi 2000;48:317-24. [Article in Turkish]
  • [40] Rahman I, MacNee W. Role of oxidants/antioxidants in smoking-induced lung diseases. Free Rad Biol Med 1996;21:669-81.
  • [41] Demir T, Aydemir A, Güler S, Serdaroğlu E, Kurutepe M, Donma O, et al. [Oxidative stress in acute and stable cases of COPD]. Solunum Dergisi 1999;1:43-7. [Article in Turkish]
  • [42] Yin H, Xu L, Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev 2011;111:5944-72.
  • [43] Ahmad A, Shameem M, Husain Q. Altered oxidant-antioxidant levels in the disease prognosis of chronic obstructive pulmonary disease. Int J Tuberc Lung Dis 2013;17:1104-9.
  • [44] Ambade V, Sontakke A, Basannar D, Tyaji R. Oxidative stress in chronic obstructive pulmonary disease alters ferroxidase activity of ceruloplasmin. Br J Med Med Res 2014;4:1257-68.
  • [45] Ambade VN, Sontakke AN, Barthwal M, Tyagi R, Basannar DR. Diagnostic utility of biomarkers in COPD. Resp Care 2015;60:1729-42.
  • [48] Can U, Yerlikaya FH, Yosunkaya S. Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease. J Chin Med Assoc 2015;78:702-8.

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Year 2019, Volume: 5 Issue: 2, 250 - 257, 04.03.2019
https://doi.org/10.18621/eurj.425178

Abstract

Objectives: The
severity of inflammation occurring during chronic obstructive pulmonary disease
(COPD) is closely associated with oxidative stress. The aim of this study was
to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and
ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD
patients.

Methods: This
prospective study was performed with COPD patients presenting to the Kırıkkale
University Hospital and with healthy volunteers. Subjects’ demographic data
(age, sex, body mass index, and smoking status), native thiol (NT), total thiol
(TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were
recorded. Statistical analysis was performed with SPSS 21.0 software.

Results: One hundred ninety
subjects were enrolled in the study, 141 COPD patients and 49 healthy
volunteers. No difference was determined between the patient and control groups
in terms of age, sex or body mass index. The antioxidant markers; NT and TT
levels and NT/TT ratio were significantly lower in the patient group compared
to the control group (p < 0.001, p < 0.001, and p
< 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT
ratios were significantly higher in the patient group (p = 0.006, p
= 0.003, and p = 0.003, respectively). Significant negative correlation
was determined between antioxidant and oxidant parameters. Sensitivity values
were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA:
77.8%. Conclusions: TDH was
impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used
to monitor oxidative stress emerging in COPD. 

References

  • [1] Fabbri LM, Hurd SS. GOLD Scientific Committee. Global strategy for the diagnosis, management and prevention of COPD: 2003 update. Eur Respir J 2003;22:1-2.
  • [2] Sengoren Dikis O, Us Dulger S, Karadag M, Demirci H. COPD cases detected by spirometry on world COPD day event in Bursa. Eur Res J 2015;1:61-5.
  • [3] Yoo CG. Pathogenesis and pathophysiology of COPD. Korean J Med 2009;77:383-400.
  • [4] Inonu H, Canbakan S, Capan N, Berktas B, Erturk A, Gulhan M. [Plasma fibrinogen and serum C-reactive protein levels in acute exacerbations and stable period of chronic obstructive pulmonary disease]. Solunum Hastalıkları Dergisi 2006;17:1-7. [Article in Turkish]
  • [5] Saugstad O. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatrica 1996;85:1-4.
  • [6] Ozcan O, Erdal H, Cakirca G, Yonden Z. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exper Invest 2015;6:331-6.
  • [7] Mccord JM. Human disease, free radicals, and the oxidant/antioxidant balance. Clin Biochem 1993;26:351-7.
  • [8] Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32.
  • [9] Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Rad Biol Med 2013;65:244-53.
  • [10] Hu ML. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 1994;233:380-5.
  • [11] Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Rad Biol Med 2010;48:749-62.
  • [12] Abuja PM, Albertini R. Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins. Clin Chim Acta 2001;306:1-17.
  • [13] Ustundag Y, Huysal K, Kahvecioglu S, Demirci H, Yavuz S, Sambel M, et al. Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates. Eur Res J 2016;2:126-31.
  • [14] Eren Y, Dirik E, Neşelioğlu S, Erel Ö. Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study. Acta Neurol Belgi 2015;115:643-9.
  • [15] Kundi H, Ates I, Kiziltunc E, Cetin M, Cicekcioglu H, Neselioglu S, et al. A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis. Am J Emerg Med 2015;33:1567-71.
  • [16] Akbas A, Kilinc F, Sener S, Aktas A, Baran P, Ergin M. Investigation of thiol-disulphide balance in patients with acute urticaria and chronic spontaneous urticaria. Cutan Ocul Toxicol 2017;36:205-10.
  • [17] Dinc ME, Ozdemir C, Ayan NN, Bozan N, Ulusoy S, Koca C, et al. Thiol/disulfide homeostasis as a novel indicator of oxidative stress in obstructive sleep apnea patients. J Laryngol 2017;130:447-52.
  • [18] Ulusoy S, Ayan NN, Dinc ME, Bicer C, Erel O. A new oxidative stress marker for thiol-disulphide homeostasis in seasonal allergic rhinitis. Am J Rhinol Allergy 2016;22:86-92.
  • [19] Gümüşyayla Ş, Vural G, Bektaş H, Neşelioğlu S, Deniz O, Erel Ö. Evaluation of dynamic thiol-disulphide homeostasis in patients with epilepsy. Epilepsia 2016;22:86-92.
  • [46] Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A, Singh SK, et al. Evaluation of oxidative stress and antioxidant status in chronic obstructive pulmonary disease. Scand J Immunol 2017;85:130-7.
  • [47] Ataş H, Kocabıyık M, Gönül M, Öztürk Y, Kavutçu M. Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo. Biomark Med 2017;11:439-49.
  • [20] Ozyazici S, Karateke F, Turan U, Kuvvetli A, Kilavuz H, Karakaya B, et al. A novel oxidative stress mediator in acute appendicitis: thiol/disulphide homeostasis. Mediators Inflamm 2016;2016:6761050.
  • [21] Ates I, Ozkayar N, Inan B, Yilmaz FM, Topcuoglu C, Neselioglu S, et al. Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension. J Am Soc Hyperten 2016;10:159-66.
  • [22] Ozler S, Erel O, Oztas E, Ersoy AO, Ergin M, Sucak A, et al. Serum thiol/disulphide homeostasis in preeclampsia. Hyperten Preg 2015;34:474-85.
  • [23] Lippi G, Montagnana M. Ischemia-modified albumin in ischemic disorders. Ann Thorac Cardiovasc Surg 2009;15:137.
  • [24] Eroglu O, Turkmen S, Mentese A, Altun G, Turedi S, Eryigit U, et al. The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology. Turk J Med Sci 2014;44:62-7.
  • [25] Gunduz A, Turedi S, Mentese A, Altunayoglu V, Turan I, Karahan SC, et al. Ischemia-modified albumin levels in cerebrovascular accidents. Am J Emerg Med 2008;26:874-8.
  • [26] Gunduz A, Turedi S, Mentese A, Karahan SC, Hos G, Tatlı O, et al. Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study. Am J Emerg Med 2008;26:202-5.
  • [27] Turedi S, Gunduz A, Mentese A, Karahan SC, Yilmaz SE, Eroglu O, et al. Value of ischemia-modified albumin in the diagnosis of pulmonary embolism. Am J Emerg Med 2007;25:770-3.
  • [28] Gulpamuk B, Tekin K, Sonmez K, Inanc M, Neselioglu S, Erel O, et al. The significance of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in patients with different stages of diabetes mellitus. Scand J Clin Lab Inv 2018;78:136-42.
  • [29] Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia: a preliminary report. J Emerg Med 2000;19:311-5.
  • [30] Umut S. KOAH patogenezinde oksidatif stress. KOAH seminer notları. In: Umut S, edition. Küre Basım: İstanbul, 1997.
  • [31] Cochrane CG. Cellular injury by oxidants. Am J Med 1991;91:23-30.
  • [32] Orhan Z, Köksal N, Gökırmak M, Hacıevliyagil S, Hasanoğlu C, Mehmet N, et al. [Oxidative stress in acute exacerbations of COPD and the effect of therapy on oxidant-antioxidant balance]. Solunum Hastalıkları Dergisi 2003;14:5-10. [Article in Turkish]
  • [33] Ergin M, Cendek B, Neselioglu S, Avsar A, Erel O. Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum. J Perinatol 2015;35:788-92.
  • [34] Kilinc F, Sener S, Akbas A, Neselioglu S, Erel O, Aktas A. Investigation of dynamic thiol-disulfide homeostasis in alopecia areata patients. Br J Med Med Res 2017;21:1-7.
  • [35] Yilmaz OH, Bal C, Neselioglu S, Buyuksekerci M, Gunduzoz M, Eren F, et al. Thiol/disulfide homeostasis in asphalt workers. Arch Envir Occup Health 2016;71:268-72.
  • [36] Babaoglu E, Kilic H, Hezer H, Dag O, Parlak E, Senturk A, et al. Comparison of thiol/disulphide homeostasis parameters in patients with COPD, asthma and ACOS. Eur Rev Med Pharmacol Sci 2016;20:1537-43.
  • [37] Taşkın D, Önderci M, Yalın S, Fakıoğlu F, Çömelekoğlu U, Yılmaz S, et al. [Antioxidant enzyme activities in patients with COPD admitted to hospitals in Adiyaman]. Adıyaman Univ Sağlık Bilim Derg 2015;1:25-38. [Article in Turkish]
  • [38] Başyiğit İ. KOAH patogenezi ve fizyopatolojisi. TTD Toraks Cerrahisi Bülteni 2010;1:114-8.
  • [39] Şahin Ü, Ünlü M, Sütçü R, Delibaş N, Akkaya A. [The effect of treatment of exacerbations of chronic obstructive pulmonary disease on oxidant/antioxidant imbalance]. Tüberküloz ve Toraks Dergisi 2000;48:317-24. [Article in Turkish]
  • [40] Rahman I, MacNee W. Role of oxidants/antioxidants in smoking-induced lung diseases. Free Rad Biol Med 1996;21:669-81.
  • [41] Demir T, Aydemir A, Güler S, Serdaroğlu E, Kurutepe M, Donma O, et al. [Oxidative stress in acute and stable cases of COPD]. Solunum Dergisi 1999;1:43-7. [Article in Turkish]
  • [42] Yin H, Xu L, Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev 2011;111:5944-72.
  • [43] Ahmad A, Shameem M, Husain Q. Altered oxidant-antioxidant levels in the disease prognosis of chronic obstructive pulmonary disease. Int J Tuberc Lung Dis 2013;17:1104-9.
  • [44] Ambade V, Sontakke A, Basannar D, Tyaji R. Oxidative stress in chronic obstructive pulmonary disease alters ferroxidase activity of ceruloplasmin. Br J Med Med Res 2014;4:1257-68.
  • [45] Ambade VN, Sontakke AN, Barthwal M, Tyagi R, Basannar DR. Diagnostic utility of biomarkers in COPD. Resp Care 2015;60:1729-42.
  • [48] Can U, Yerlikaya FH, Yosunkaya S. Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease. J Chin Med Assoc 2015;78:702-8.
There are 48 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Oğuz Eroğlu 0000-0001-7033-8566

Nermin Dindar Badem 0000-0002-5095-7818

Ayşe Baccıoğlu 0000-0002-9853-9201

Ertan Cömertpay This is me 0000-0002-8648-5963

Salim Neşelioğlu This is me 0000-0002-0974-5717

Özcan Erel 0000-0002-2996-3236

Publication Date March 4, 2019
Submission Date May 19, 2018
Acceptance Date June 6, 2018
Published in Issue Year 2019 Volume: 5 Issue: 2

Cite

AMA Eroğlu O, Dindar Badem N, Baccıoğlu A, Cömertpay E, Neşelioğlu S, Erel Ö. Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease. Eur Res J. March 2019;5(2):250-257. doi:10.18621/eurj.425178

e-ISSN: 2149-3189 


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