Evaluation of plasma catestatin levels in patient with coronary slow flow

Year 2019, Volume: 5 Issue: 3, 522 - 528, 04.05.2019

Dursun Topal , Bedrettin Boyraz Alkame Akgümüş Tezcan Peker Mustafa Yılmaz Fahriye Vatansever Ağca Selçuk Kanat Ömür Aydın Burhan Aslan

https://doi.org/10.18621/eurj.372631

Cited By: 1

Abstract

Objectives: Coronary slow flow (CSF) is characterized by delayed opasification of the
coronary arteries in the absence of obstructive coronary disease. Catestatin
has several cardiovasculer actions, in addition to diminihed sympato-adrenal
flow. The study was to investigated associations between CSF and plasma
catestatin levels.

Method:. This study included 45
CSF patients (37 male, mean age 48 ± 9.5 years) and 30 control individuals (24
male, mean age 48.4 ± 9 years). Coronary
flow was quantified according to the TIMI (Thrombolysis in Myocardial Infarction)
frame count method for coronary arteries. Serum
catestatin levels taken from blood samples were measured by ELISA method. These parameters were compared between the groups.

Results: When
compared with to the control group the serum catestatin levels
was found higher in the CSF group. In addition to this, mean platelet volume
was also significantly higher in patients with
coronary slow flow.

Conclusions: Our study revealed that catestatin levels are increased in
patients with CSF. Coronary slow flow
that increased catecholaminergic sympathetic system activities seem to be among
the reasons of endothelial dysfunction. 

Keywords

catestatin, coronary slow flow, coronary artery disease

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