Research Article
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The correlation between red cell distribution width, autoimmunity and nail involvement in alopecia areata

Year 2019, Volume: 5 Issue: 4, 623 - 628, 04.07.2019
https://doi.org/10.18621/eurj.408089

Abstract

Objectives:
Alopecia areata is a widespread autoimmune
disease that targets hair follicles, and is characterized by nonscarring
patches of hair loss. Red cell distribution width (RDW) is a routinely analyzed
parameter during complete blood count, and indicates variations in diameters of
red blood cells. Elevated RDW levels are associated with high level of
inflammation and oxidative stress. In this study, we aimed to demonstrate the
correlation between RDW levels, autoimmunity, and nail involvement in alopecia
areata.

Methods: Medical records of 170 patients who were admitted to
our dermatology clinic between May 2016 and May 2017 were retrospectively
evaluated. A total of 170 patients with alopecia areata diagnosis were
evaluated.

Results: The mean age of the patients was 24.61 ± 12.62 years
(3-59 years). Sixty patients (35.3%) were female, and 110 patients (64.7%) were
male. Twenty-seven patients (15.9%) had nail involvement, and 24 patients
(14.1%) had a history of an autoimmune disease. RDW levels were significantly
higher in patients with nail involvement and history of an autoimmune disease.







Conclusion: RDW can be used as a simple, cheap, and readily available
marker of inflammation in patients with alopecia areata.

References

  • [1] Alexis AF, Dudda-Subramanya R, Sinha AA. Alopecia areata: autoimmune basis of hair loss. Eur J Dermatol 2004;14:364-70.
  • [2] Kyriakis KP, Paltatzidou K, Kosma E, Sofouri E, Tadros A, Rachioti E. Alopecia areata prevalence by gender and age. J Eur Acad Dermatol Venereol 2009;23:572-3.
  • [3] Cotsarelis G, Botchkarev V. Biology of hair follicles. In:Wolff K, Katz SI, Goldsmith LA, Goldsmith L, Gilchrest B, Paller A, Leffell D, et al. Fitzpatrick’s Dermatology in General Medicine. 7th ed. New York: Mc Graw Hill, 2007:pp. 39-9.
  • [4] Hordinsky MK. Alopecias. In:Horn, TD, Mascaro JM, Mancini AJ, et al. Dermatology. 1st ed. London: Mosby, 2003:pp. 1033-59.
  • [5] Wasserman D, Guzman-Sanchez DA, Scott K, McMichael A. Alopecia areata. Int J Dermatol 2007;46:121-31.
  • [6] Seçkin HY, Bütün I, Baş Y, Takcı Z, Kalkan G. Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis. J Dermatolog Treat 2016;27:389-91.
  • [7] Schoorl M, Schoorl M, van Pelt J, Bartels PC. Application of innovative hemocytometric parameters and algorithms for improvement of microcytic anemia discrimination. Hematol Rep 2015;7:5843.
  • [8] Kim DS, Shin D, Kim TG, Kim SH, Kim DY, Kim SM, et al. Red blood cell distribution width as a useful indicator to predict systemic vasculitis in patients with cutaneous vasculitis. Rheumatol Int 2015;35:719-25.
  • [9] Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, et al; CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40-7.
  • [10] Kurtul BE, Kabatas EU, Boybeyi SD, Caglar AA, Ozer PA. Increased red cell distribution width levels in children with seasonal allergic conjunctivitis. Int Ophthalmol 2018;38:1079-84.
  • [11] Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol 2006;20:1055-60.
  • [12] Kavak A, Yeşildal N, Parlak AH, Gökdemir G, Aydoğan I, Anul H, et al. Alopecia areata in Turkey: demographic and clinical features. J Eur Acad Dermatol Venereol 2008;22:977-81.
  • [13] Blaumeiser B, van der Goot I, Fimmers R, Hanneken S, Ritzmann S, Seymons K, et al. Familial aggregation of alopecia areata. J Am Acad Dermatol 2006;54:627-32.
  • [14] Seyrafi H, Akhiani M, Abbasi H, Mirpour S, Gholamrezanezhad A. Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients. BMC Dermatol 2005;5:11.
  • [15] Berker DAR, Messenger AG, Sinclair RD. Disorders of hair. In: Rook’s Textbook of Dermatology. Burns T, Breathnach S, Cox N, Griffiths C, eds. 7th ed. Oxford: Blackwell Science, 2004:pp. 1-63.
  • [16] Gandhi V, Baruah MC, Bhattacharaya SN. Nail changes in alopecia areata: incidence and pattern. Indian J Dermatol Venereol Leprol 2003;69:114-5.
  • [17] Kasumagic-Halilovic E, Prohic A. Nail changes in alopecia areata: frequency and clinical presentation. J Eur Acad Dermatol Venereol 2009;23:240-1.
  • [18] Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol 1996;35:22-7.
  • [19] Pancar GS, Eyupoglu O. Red cell distribution width and mean platelet volume in patients with pityriasis rosea. J Clin Med Res 2016;8:445-8.
  • [20] Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-32.
  • [21] Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
  • [22] Kim DS, Shin D, Jee H, Kim TG, Kim SH, Kim DY, et al. Red blood cell distribution width is increased in patients with psoriasis vulgaris: a retrospective study on 261 patients. J Dermatol 2015;42:567-71.
  • [23] Farkas N, Szabó A, Lóránd V, Sarlós DP, Minier T, Prohászka Z, et al. Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. Rheumatology (Oxford) 2014;53:1439-45.
  • [24] Lou Y, Wang M, Mao W. Clinical usefulness of measuring red blood cell distribution width in patients with hepatitis B. PLoS One 2012;7:e37644.
Year 2019, Volume: 5 Issue: 4, 623 - 628, 04.07.2019
https://doi.org/10.18621/eurj.408089

Abstract

References

  • [1] Alexis AF, Dudda-Subramanya R, Sinha AA. Alopecia areata: autoimmune basis of hair loss. Eur J Dermatol 2004;14:364-70.
  • [2] Kyriakis KP, Paltatzidou K, Kosma E, Sofouri E, Tadros A, Rachioti E. Alopecia areata prevalence by gender and age. J Eur Acad Dermatol Venereol 2009;23:572-3.
  • [3] Cotsarelis G, Botchkarev V. Biology of hair follicles. In:Wolff K, Katz SI, Goldsmith LA, Goldsmith L, Gilchrest B, Paller A, Leffell D, et al. Fitzpatrick’s Dermatology in General Medicine. 7th ed. New York: Mc Graw Hill, 2007:pp. 39-9.
  • [4] Hordinsky MK. Alopecias. In:Horn, TD, Mascaro JM, Mancini AJ, et al. Dermatology. 1st ed. London: Mosby, 2003:pp. 1033-59.
  • [5] Wasserman D, Guzman-Sanchez DA, Scott K, McMichael A. Alopecia areata. Int J Dermatol 2007;46:121-31.
  • [6] Seçkin HY, Bütün I, Baş Y, Takcı Z, Kalkan G. Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis. J Dermatolog Treat 2016;27:389-91.
  • [7] Schoorl M, Schoorl M, van Pelt J, Bartels PC. Application of innovative hemocytometric parameters and algorithms for improvement of microcytic anemia discrimination. Hematol Rep 2015;7:5843.
  • [8] Kim DS, Shin D, Kim TG, Kim SH, Kim DY, Kim SM, et al. Red blood cell distribution width as a useful indicator to predict systemic vasculitis in patients with cutaneous vasculitis. Rheumatol Int 2015;35:719-25.
  • [9] Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, et al; CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40-7.
  • [10] Kurtul BE, Kabatas EU, Boybeyi SD, Caglar AA, Ozer PA. Increased red cell distribution width levels in children with seasonal allergic conjunctivitis. Int Ophthalmol 2018;38:1079-84.
  • [11] Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol 2006;20:1055-60.
  • [12] Kavak A, Yeşildal N, Parlak AH, Gökdemir G, Aydoğan I, Anul H, et al. Alopecia areata in Turkey: demographic and clinical features. J Eur Acad Dermatol Venereol 2008;22:977-81.
  • [13] Blaumeiser B, van der Goot I, Fimmers R, Hanneken S, Ritzmann S, Seymons K, et al. Familial aggregation of alopecia areata. J Am Acad Dermatol 2006;54:627-32.
  • [14] Seyrafi H, Akhiani M, Abbasi H, Mirpour S, Gholamrezanezhad A. Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients. BMC Dermatol 2005;5:11.
  • [15] Berker DAR, Messenger AG, Sinclair RD. Disorders of hair. In: Rook’s Textbook of Dermatology. Burns T, Breathnach S, Cox N, Griffiths C, eds. 7th ed. Oxford: Blackwell Science, 2004:pp. 1-63.
  • [16] Gandhi V, Baruah MC, Bhattacharaya SN. Nail changes in alopecia areata: incidence and pattern. Indian J Dermatol Venereol Leprol 2003;69:114-5.
  • [17] Kasumagic-Halilovic E, Prohic A. Nail changes in alopecia areata: frequency and clinical presentation. J Eur Acad Dermatol Venereol 2009;23:240-1.
  • [18] Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol 1996;35:22-7.
  • [19] Pancar GS, Eyupoglu O. Red cell distribution width and mean platelet volume in patients with pityriasis rosea. J Clin Med Res 2016;8:445-8.
  • [20] Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-32.
  • [21] Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
  • [22] Kim DS, Shin D, Jee H, Kim TG, Kim SH, Kim DY, et al. Red blood cell distribution width is increased in patients with psoriasis vulgaris: a retrospective study on 261 patients. J Dermatol 2015;42:567-71.
  • [23] Farkas N, Szabó A, Lóránd V, Sarlós DP, Minier T, Prohászka Z, et al. Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. Rheumatology (Oxford) 2014;53:1439-45.
  • [24] Lou Y, Wang M, Mao W. Clinical usefulness of measuring red blood cell distribution width in patients with hepatitis B. PLoS One 2012;7:e37644.
There are 24 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Gülhan Gürel 0000-0001-5716-8750

Publication Date July 4, 2019
Submission Date March 20, 2018
Acceptance Date November 22, 2018
Published in Issue Year 2019 Volume: 5 Issue: 4

Cite

AMA Gürel G. The correlation between red cell distribution width, autoimmunity and nail involvement in alopecia areata. Eur Res J. July 2019;5(4):623-628. doi:10.18621/eurj.408089

e-ISSN: 2149-3189 


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