Research Article
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Year 2019, Volume: 5 Issue: 5, 868 - 872, 04.09.2019
https://doi.org/10.18621/eurj.429257

Abstract

References

  • [1] Zribi N, Chakroun NF, Elleuch H, Abdallah FB, Hamida ASB, Gargouri J, et al. Sperm DNA fragmentation and oxidation are independent of malondialdheyde. Reprod Biol Endocrinol 2011;9:47-55.
  • [2] Sakkas D, Alvarez JG. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil and Steril 2010;93:1027-36.
  • [3] Sharif K, Lewis EML. Debate Sperm DNA fragmentation testing: To do or not to do. Middle East Fertil Soc J 2013;18:78-83.
  • [4] Robinson L, Gallos ID, Conner SJ, Rajkhowa M, Miller D, Lewis S, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod 2012;27:2908-17.
  • [5] More K, Badade ZG, Narshetty JG, Joshi DS, Mukherjee S, Deepak AD, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. J Mahatma Gandhi Inst Med Sci 2014;1:1-6.
  • [6] Lopes S, Jurisicova, Sun JG, Casper RF. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum Reprod 1998;13:896-900.
  • [7] Gual-Frau J, Abad C, Amenguel MJ, Hannaoui N, Checa MA, Ribas-Maynou J, et al. Oral antioxidant treatmen partly improves integrity of human sperm DNA in infertile grade 1 varicocele patients. Hum Fertil 2015;18:225-9.
  • [8] Martinez-Soto JC, Domingos JC, Cordobilla B, Nicolas M, Fernandez L, Albero P, et al. Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Syst Biol Reprod Med 2016;62: 387-95.
  • [9] Menezo YR, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online 2007;14:418-21.
  • [10] Amar E, Cornet D, Cohen M, Menezo Y. Treatment for hihg levels of sperm DNA fragmentation and nuclear decondensation: sequential treatment with a potent antioxidant followed by stimulation of the one-carbon cycle vs one-carbon cycle back-up alone. Austin J Reprod Med Infertil 2015;2:1-5.
  • [11] Greco E, Romano S, Iacobelli M, Ferrero S, Baroni E, Minasi MG, et al. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Hum Reprod 2005;20:2590-4.
  • [12] Tunc O, Thompson J, Tremellen K. Improvement in sperm DNA quality using an oral antioxidant therapy. Reprod Biomed Online 2009;18:761-8.
  • [13] Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005;26:349-53.
  • [14] Abad C, Amengual MJ, Gosalvez J, Coward K, Hannaoui N, Benet J, et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013;45:211-6.

Intracytoplasmic sperm injection outcomes after anti-oxidant treatment in repeated implantation failure

Year 2019, Volume: 5 Issue: 5, 868 - 872, 04.09.2019
https://doi.org/10.18621/eurj.429257

Abstract

Objectives:
Aim of this study was to explore the effects of three
months oral anti-oxidant treatment in normozoospermic men with high DNA fragmentation
index (DFI) and recurrent
intracytoplasmic sperm injection (ICSI) failures.

Methods: This is a retrospective
analyses of normozoospermic patients with high DFI levels (> 30%) with at least
two unsuccessful ICSI attempts. Among the participants, the study group included
men who had oral anti-oxidant treatment. The men who did not receive any treatment
during the study period were taken as controls. The outcomes of new ICSI cycles
were compared.

Results: During the
study period 24 men have used three months of oral anti-oxidant treatment before
a new ICSI cycle whereas the remaining 46 had ICSI-only without any other intervention.
Duration of stimulation, the number of
metaphase II oocytes, fertilization
rate and implantation rates were similar between two groups. Although not statistically
significant, cases in anti-oxidant group have slightly better pregnancy rates compared
to ICSI-only group (37.5% vs 19.6%,
p > 0.05). Only one case in each group
had abortion.







Conclusions: This study
reveals that there is no statistically significant difference in the ICSI outcomes
of the patients with high DFI levels, following unsuccessful ICSI attempts after
oral anti-oxidant treatment. The possible benefit derived from the anti-oxidant
therapy needs to be clarified with clinical studies with greater study populations. 

References

  • [1] Zribi N, Chakroun NF, Elleuch H, Abdallah FB, Hamida ASB, Gargouri J, et al. Sperm DNA fragmentation and oxidation are independent of malondialdheyde. Reprod Biol Endocrinol 2011;9:47-55.
  • [2] Sakkas D, Alvarez JG. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil and Steril 2010;93:1027-36.
  • [3] Sharif K, Lewis EML. Debate Sperm DNA fragmentation testing: To do or not to do. Middle East Fertil Soc J 2013;18:78-83.
  • [4] Robinson L, Gallos ID, Conner SJ, Rajkhowa M, Miller D, Lewis S, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod 2012;27:2908-17.
  • [5] More K, Badade ZG, Narshetty JG, Joshi DS, Mukherjee S, Deepak AD, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. J Mahatma Gandhi Inst Med Sci 2014;1:1-6.
  • [6] Lopes S, Jurisicova, Sun JG, Casper RF. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum Reprod 1998;13:896-900.
  • [7] Gual-Frau J, Abad C, Amenguel MJ, Hannaoui N, Checa MA, Ribas-Maynou J, et al. Oral antioxidant treatmen partly improves integrity of human sperm DNA in infertile grade 1 varicocele patients. Hum Fertil 2015;18:225-9.
  • [8] Martinez-Soto JC, Domingos JC, Cordobilla B, Nicolas M, Fernandez L, Albero P, et al. Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Syst Biol Reprod Med 2016;62: 387-95.
  • [9] Menezo YR, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online 2007;14:418-21.
  • [10] Amar E, Cornet D, Cohen M, Menezo Y. Treatment for hihg levels of sperm DNA fragmentation and nuclear decondensation: sequential treatment with a potent antioxidant followed by stimulation of the one-carbon cycle vs one-carbon cycle back-up alone. Austin J Reprod Med Infertil 2015;2:1-5.
  • [11] Greco E, Romano S, Iacobelli M, Ferrero S, Baroni E, Minasi MG, et al. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Hum Reprod 2005;20:2590-4.
  • [12] Tunc O, Thompson J, Tremellen K. Improvement in sperm DNA quality using an oral antioxidant therapy. Reprod Biomed Online 2009;18:761-8.
  • [13] Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005;26:349-53.
  • [14] Abad C, Amengual MJ, Gosalvez J, Coward K, Hannaoui N, Benet J, et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013;45:211-6.
There are 14 citations in total.

Details

Primary Language English
Subjects Urology, Obstetrics and Gynaecology
Journal Section Original Articles
Authors

Semih Tangal 0000-0003-1394-2454

Gamze Sinem Çağlar 0000-0003-1956-0908

Emre Göksan Pabuçcu 0000-0001-9015-5978

Müge Keskin This is me 0000-0001-7510-7898

Ahmet Hakan Haliloğlu 0000-0002-6008-2509

Publication Date September 4, 2019
Submission Date May 31, 2018
Acceptance Date August 10, 2018
Published in Issue Year 2019 Volume: 5 Issue: 5

Cite

AMA Tangal S, Çağlar GS, Pabuçcu EG, Keskin M, Haliloğlu AH. Intracytoplasmic sperm injection outcomes after anti-oxidant treatment in repeated implantation failure. Eur Res J. September 2019;5(5):868-872. doi:10.18621/eurj.429257

e-ISSN: 2149-3189 


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