Year 2019, Volume 5 , Issue 6, Pages 990 - 995 2019-11-04

The efficacy of bleb needling revision with 5-fluorouracil in encapsulated bleb after unsuccessful trabeculectomy

Mehmet Okka [1] , Enver Mirza [2] , Refik Oltulu [3] , Selman Belviranlı [4] , Mehmet Kemal Gündüz [5]


Objectives: To investigate the efficacy of the bleb needling revision (BNR) procedure with the adjunctive use of 5-Fluorouracil (5-FU) in encapsulated bleb after unsuccessful trabeculectomy.

Methods: We reviewed 16 eyes of 15 subjects who underwent BNR procedure due to encapsulated bleb after unsuccessful trabeculectomy. Demographic data, type of glaucoma, intraocular pressure (IOP) values of pre-BNR, IOP values of post-BNR at first day, first week and first month, follow up time and complications were recorded from patients’ files, retrospectively.

Results: The mean follow up time was 53.1 ± 26.4 weeks. The average time between previous unsuccessful trabeculectomy and BNR was 11.12 ± 8.79 weeks. The mean IOP of pre-BNR was 26.0 ± 4.4 mmHg and significantly decreased to 12.4 ± 5.0 mmHg post-BNR at the first day (p < 0.001). The mean IOP values of post-BNR at the first week was 13.3 ± 4.9 mmHg and at the first month was 14.8 ± 4.8 mmHg. According to the mean IOP of pre-BNR, the mean IOP values of post-BNR at the first week and at the first month were significantly lower (p < 0.001 and p < 0.001, respectively). Seven (44%) eyes were achieved success and eight (50%) eyes were achieved qualified success. One (6%) eye was classified as the failure.

Conclusion: The bleb needling revision procedure with the adjunctive use of 5-FU in encapsulated bleb after unsuccessful trabeculectomy is a simple, useful and repeatable method to restore the dysfunctional bleb. 

Bleb needling revision, 5-Fluorouracil, encapsulated bleb, trabeculectomy, filtration surgery
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Primary Language en
Subjects Ophthalmology
Journal Section Original Articles
Authors

Orcid: 0000-0002-3908-1042
Author: Mehmet Okka
Institution: Department of Ophthalmology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey
Country: Turkey


Orcid: 0000-0002-8847-5726
Author: Enver Mirza (Primary Author)
Institution: Department of Ophthalmology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey
Country: Turkey


Orcid: 0000-0003-2447-6524
Author: Refik Oltulu
Institution: Department of Ophthalmology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey
Country: Turkey


Orcid: 0000-0002-4177-6046
Author: Selman Belviranlı
Institution: Department of Ophthalmology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey
Country: Turkey


Orcid: 0000-0001-9105-6429
Author: Mehmet Kemal Gündüz
Institution: Department of Ophthalmology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey
Country: Turkey


Dates

Publication Date : November 4, 2019

EndNote %0 The European Research Journal The efficacy of bleb needling revision with 5-fluorouracil in encapsulated bleb after unsuccessful trabeculectomy %A Mehmet Okka , Enver Mirza , Refik Oltulu , Selman Belviranlı , Mehmet Kemal Gündüz %T The efficacy of bleb needling revision with 5-fluorouracil in encapsulated bleb after unsuccessful trabeculectomy %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 6 %R doi: 10.18621/eurj.425740 %U 10.18621/eurj.425740