Clinical significance of mean platelet volume/lymphocyte ratio and mean platelet volume/platelet ratio in the exacerbation of chronic obstructive pulmonary disease

Year 2019, Volume: 5 Issue: 6, 1001 - 1006, 04.11.2019

Emine Özsarı , Mehmet Zahid Koçak

https://doi.org/10.18621/eurj.443660

Cited By: 1

Abstract

Objectives:
Studies
showing the role of systemic inflammation in chronic obstructive pulmonary disease (COPD)
are increasing. Particularly, importance of mean platelet volume (MPV) and
neutrophil/lymphocyte ratio (NLR) for acute exacerbation of COPD has been
reported. The use of MPV/lymphocyte ratio (MLR) and MPV/platelet ratio(MPR) in
acute exacerbation of COPD patients was investigated in our study, considering
that MPV alone may be a more valuable marker of inflammation.

Methods: Between March 2017 and March 2018, COPD patients who applied to Abant Izzet Baysal
University School of Medicine, Chest Diseases outpatient clinic were examined. Results
were retrospectively scanned from patient files after institutional approval. Sixty-four
(60.4%) stable COPD and 42 (39.6%) acute exacerbation COPD patients were
included in the study.

Results: Seventy-one
(67%) of patients were male and 35 (33%) were female. NLR was 2.26 (0.93-6.48)
in stable patients and 4 (1.18-36) in acute attack patients (p < 0.001); PLR was 137.44
(66.9-436.6) in patients with stable disease and 162.8 (85-1056.6) in patients
with attack (p = 0.068). MLR was 5 (2.92-25)
in acute attack patients and 4 (1.89-8.67) in stable patients; this difference was
statistically significant (p = 0.003).
MPV was found to be 7 (5.5-9.1) fL in patients with stable disease and 8
(5-13.4) fL in acute patients. This difference was statistically significant (p < 0.001). MPR was found to be
statistically significantly higher in acute patients than in patients with
stable disease (p = 0.04). WBC, neutrophil
and CRP were found to be statistically significantly higher in acute patients
than in stable patients (p < 0.05).
There was a statistically significant correlation between WBC and NLR (r =
0.269, p = 0.005) and between CRP and
NLR (r = 0.379, p < 0.001).

Conclusions: Hemogram
parameters from routine laboratory tests in COPD patients are cheap and easily
accessible. It is important to detect the presence of subclinical inflammation
in the stable phase, as well as to identify patients at risk of exacerbation. Prospective
studies are needed to demonstrate correlations with inflammatory markers. 

Keywords

Mean platelet volume, neutrophil/lymphocyte ratio, lymphocyte, platelet, chronic obstructive pulmonary disease

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