Year 2020, Volume 6 , Issue 2, Pages 163 - 168 2020-03-04

Evaluation of the relationship between serum cholesterol levels and multiple sclerosis disease activity

Meral SEFEROGLU [1] , Nizameddin KOCA [2]


Objectives: Multiple sclerosis (MS) is an immune-mediated, inflammatory, demyelinating, neurodegenerative disease of the central nervous system affecting young adults. Cholesterol and lipids are essential components of nerve cells and are abundant in the myelin sheath. In this study, we aimed to investigate the relationship between plasma cholesterol levels and severity of the disease and lesion burden in cranial magnetic resonance imaging.

Methods: A total of 70 patients (22 males and 48 females) with the diagnosis of MS were included in the study. Age, gender, duration of disease, Expanded Disability Status Scale (EDSS) scores, total number of relapses since diagnosis, current treatment and lipid levels of all participants were recorded. The patients were grouped according to EDSS scores, total number of relapses and number of lesions observed in cranial MRI and the data were compared among the groups.

Results: The mean age was 38.62 ± 9.94 years and the duration of the disease was 7.50 ± 5.88 years. The mean EDSS score was 2.80 ± 1.69. Total cholesterol, triglyceride and LDL levels were found to be significantly higher in the group with more than 3 relapses. Patients with > 9 lesions were older and EDSS scores were higher. In correlation analysis; there was a significant positive correlation between total cholesterol and LDL levels and EDSS scores and disease duration.

Conclusions: We found that the number of relapses, disease duration, and EDSS scores were significantly correlated with cholesterol levels. The changes in plasma cholesterol levels which are easily accessible laboratory tests may provide insight into MS disease activity and progression. 

multiple sclerosis, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides
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Primary Language en
Subjects General and Internal Medicine, Clinical Neurology
Journal Section Original Articles
Authors

Orcid: 0000-0003-3858-0306
Author: Meral SEFEROGLU
Institution: Department of Neurology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0003-1457-4366
Author: Nizameddin KOCA (Primary Author)
Institution: Department of Internal Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Dates

Publication Date : March 4, 2020

EndNote %0 The European Research Journal Evaluation of the relationship between serum cholesterol levels and multiple sclerosis disease activity %A Meral SEFEROGLU , Nizameddin KOCA %T Evaluation of the relationship between serum cholesterol levels and multiple sclerosis disease activity %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 2 %R doi: 10.18621/eurj.658361 %U 10.18621/eurj.658361