The effects of fulvestrant treatment on hormone receptor-positive metastatic breast cancer

Year 2020, Volume: 6 Issue: 3, 210 - 215, 04.05.2020

Serdar Arıcı Çağlayan Geredeli Şaban Seçmeler Abdullah Sakin Orçun Can Nurgül Yaşar Şener Cihan

https://doi.org/10.18621/eurj.470881

Cited By: 1

Abstract

Objectives:
To
determine fulvestrant efficacy and tolerability in Turkish patients with
hormone receptor-positive metastatic breast cancer.

Methods: Patients
who developed metastasis while taking tamoxifen or aromatase inhibitors in the
adjuvant period or metastatic disease at the diagnosis. Fulvestrant 500 mg was
administered intramuscularly every 28 days. Progression-free survival (PFS) and
overall survival (OS) durations were calculated.

Results: In this
particular research, totally 137 patients were participated. Median PFS was 9 months
(95% CI, 5.7-10.3). The 12-month PFS rate was calculated as 42%, and the
36-month PFS rate was 17%. The median PFS was not reached in the first line use
of fulvestrant in the metastatic period but 9 months and 7 months in the second
and subsequent lines respectively. Results indicated that this difference was
statistically significant (p =
0.002). It was shown that patients with liver and brain metastasis had lower
PFS compared patients with no liver and no brain metastasis. The estimated
median OS was 38 months after fulvestrant started. The 12-month OS rate was
calculated as 82.4%, and the 36-month OS rate was 50%.

Conclusions: Fulvestrant contributes both PFS and OS in patients with
hormone receptor-positive metastatic breast cancer and this effect is more
clear in using fulvestrant as first-line treatment. 

Keywords

fulvestrant, breast cancer, endocrine treatment

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