Year 2020, Volume 6 , Issue 3, Pages 238 - 247 2020-05-04

The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication

Sinay ÖNEN [1] , İbrahim TAYMUR [2]

Objectives: In recent years there has been an increased interest on the role of inflammation in the pathophysiology of schizophrenia and a search for readily applicable prognostic markers. The impact of electroconvulsive therapy (ECT) on inflammatory function in schizophrenia is still unclear. The aim of this retrospective study is to compare pre- and post-ECT values of red cell distribution width (RDW), mean platelet volume (MPV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) which are considered to be inflammatory markers, and to discuss the findings in context of neuroinflammatory ethiology of schizophrenia.

Methods: Inpatient files were reviewed via complete blood count (CBC), sociodemographic and clinical characteristics (e.g. gender, age, Body Mass Index (BMI), type of psychotropic medication). A total of 58 schizophrenic patients who underwent ECT were were compared in terms of pre- and post-ECT values of RDW, MPV, MCH, MCHC, NLR and PLR in association with type of psychotropic medication.

Results: It was found that MPV, RDW, MCH and MCHC levels significantly decreased after ECT (p < 0.05), but no significant difference was found in terms of NLR and PLR (p > 0.05). When compared according to the type of psychotropic medication during ECT, MPV and MCHC were decreased after ECT in both typicaland atypical antipsychoticintervention groups (p < 0.05). ECT-related inflammatory marker changes were more likely to be associated with atypical antipsychotic medication use during ECT.

Conclusions: Our results indicate that recurrent ECT sessions caused a change in the function of the immune system which might be considered to explain the therapeutic effects of ECT in schizophrenia. 

electroconvulsive therapy, schizophrenia, inflammatory markers, antipsychotic medication, immune system
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Primary Language en
Subjects Psychiatry
Journal Section Original Articles

Orcid: 0000-0002-5683-3971
Author: Sinay ÖNEN (Primary Author)
Institution: Department of Pscyhiatry, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey

Orcid: 0000-0002-7017-4730
Author: İbrahim TAYMUR
Institution: Department of Pscyhiatry, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey

Supporting Institution The author disclosed that they did not receive any grant during conduction or writing of this study.

Application Date : July 3, 2019
Acceptance Date : July 24, 2019
Publication Date : May 4, 2020

EndNote %0 The European Research Journal The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication %A Sinay Önen , İbrahim Taymur %T The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 3 %R doi: 10.18621/eurj.586551 %U 10.18621/eurj.586551