Year 2020, Volume 6 , Issue 4, Pages 326 - 336 2020-07-04

Clinical and electrophysiological follow-up of modafinil treatment for multiple sclerosis patients with fatigue symptom

Özlem AKDOĞAN [1] , Cemile HAKİ [2] , Ömer Faruk TURAN [3] , Özlem TAŞKAPILIOĞLU [4]


Objectives: In our study, we investigated the effects of modafinil therapy on clinical and neurophysiological tests of multiple sclerosis (MS) patients with fatigue.

Methods: The study was performed on 18 MS patients (16 females, 2 males) at Uludağ University School of Medicine, Department of Neurology, who are followed up according to Mc Donald’s criteria, who had 36 points or above based on the fatigue assesment scala (FAS), whose Beck depression inventory points were 16 and below, whose thyroid, liver and renal functions were evaluated as normal, and who had no systemic disorder. All patients had neurological examination and their expanded disability status scale (EDSS), fatigue impact scala (FIS) and multiple sclerosis quality of life (MSQoL-54) were evaluated. Somatosensory evoked potential (SEP), visual evoked potential (VEP), brainstem auditory evoked potential (BAEP), visual event related evoked potential (visual P300) were performed in our neurophysiology laboratory. After that the patients were given modafinil 100 mgr 1×1 (morning) for 1 week, the following weeks 2×1 (morning and noon). At the end of the 6 weeks of therapy the patients were called to the neurology polyclinic, and their neurological examinations, EDSS, FIS, MSQoL-54, SEP, VEP, BAEP and visual P300 were repeated.

Results: When the patients’ previous and subsequent FIS and MSQoL-54 total scores were compared, a significant statistical difference was found. When all 3 subgroups of FIS (consciousness, physical and social) were evaluated after the modafinil therapy, a significant statistical decrease in previous and successive scores were found. It is found out that modafinil therapy improves life quality which is evaluated due to MSQoL-54 (p < 0.05). A significant statistical relation between the number of MS disease attacks and the three subgroups of MFIS was not figured out (p > 0.05). There were no statistically significant relation between the FAS, EDSS and Beck depression inventory scores before the modafinil therapy had been applied (p > 0.05). There was a statistically correlation between Beck depression inventory score and FIS’s social subgroup (p = 0.017). When the patient’s SEP, VEP, BAEP, visual P300 average test values before and after the modafinil therapy were compared, a statistically significant difference was not observed.

Conclusions: In our study, it is found that modafinil therapy, which is used against fatigue, one of the MS disase’s most common symptom, has a positive impact on MS life quality and patients’ clinical symptoms of fatigue, although it has no effect on patients’ evoked potential methods (BAEP, SEP, VEP, visual P300) performed in neurophysiology laboratory. 

multiple sclerosis, fatigue, modafinil, evoked potential, fatigue severity scala
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Primary Language en
Subjects Neurosciences
Journal Section Original Articles
Authors

Orcid: 0000-0002-8656-4581
Author: Özlem AKDOĞAN
Institution: Department of Neurology, University of Health Sciences, İstanbul Training and Research Hospital, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0002-9679-8007
Author: Cemile HAKİ (Primary Author)
Institution: Department of Neurology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-6752-1519
Author: Ömer Faruk TURAN
Institution: Department of Neurology, Uludağ University School of Medicine, Bursa, Turkey
Country: Turkey


Orcid: 0000-0003-4436-3797
Author: Özlem TAŞKAPILIOĞLU
Institution: Department of Neurology, Acıbadem University School of Medicine, İstanbul, Turkey
Country: Turkey


Dates

Publication Date : July 4, 2020

EndNote %0 The European Research Journal Clinical and electrophysiological follow-up of modafinil treatment for multiple sclerosis patients with fatigue symptom %A Özlem Akdoğan , Cemile Haki̇ , Ömer Faruk Turan , Özlem Taşkapılıoğlu %T Clinical and electrophysiological follow-up of modafinil treatment for multiple sclerosis patients with fatigue symptom %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 4 %R doi: 10.18621/eurj.493073 %U 10.18621/eurj.493073