Year 2020, Volume 6 , Issue 4, Pages 314 - 318 2020-07-04

Graves’ disease and thyroiditis can be differentiated using only free thyroid hormone levels

Hilmi Erdem SÜMBÜL [1] , Fettah ACIBUCU [2]


Objectives: As the treatment approaches of Graves’ disease and thyroiditis are different, differential diagnosis is important. In this study, we analyzed whether it is possible to perform a differential diagnosis for these two conditions by checking the increase ratio of free thyroid hormones.

Methods: In total 156 patients were taken into this study of which 29 were thyroiditis (17 had subacute thyroiditis, 6 had post-partum and 6 had silent thyroiditis) and 127 were Graves patients. The age, free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH) levels, FT3 index (FT3/FT3 upper limit of normal (ULN)), FT4 index (FT4/FT4 ULN) and free thyroid hormone index (FTHI) (FT3 index/FT4 index) of all patients were determined.

Results: A significant difference was found between the mean TSH, FT3 and FT3 index between Graves’ disease and thyroiditis (p = 0.036, p = 0.001 and  p =0.001, respectively). When the groups were compared in terms of FTHI, the difference was found statistically significant (p = 0.001). FTHI was above 1 in all patients with Graves’ disease whereas it was found below 1 in all patients with thyroiditis. There were no statistically significant difference between the Graves’ disease and the thyroiditis in terms of age, FT4 and FT4 index (p = 0.748, p = 0.389 and p = 0.392, respectively).

Conclusion: Based on these results, considering the increases in free thyroid hormone values we can say that it is possible to perform a differential diagnosis of Graves’ disease and thyroiditis, and that this may be used as a practical method to differentiate these two conditions. 

Graves’ disease, thyroiditis, free thyroid hormone index
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Primary Language en
Subjects Endocrinology and Metabolism, General and Internal Medicine
Journal Section Original Articles
Authors

Orcid: 0000-0002-7192-0280
Author: Hilmi Erdem SÜMBÜL (Primary Author)
Institution: Department of Internal Medicine, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey
Country: Turkey


Orcid: 0000-0002-2252-2112
Author: Fettah ACIBUCU
Institution: Department of Endocrinology and Metabolic Diseases, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey
Country: Turkey


Dates

Publication Date : July 4, 2020

EndNote %0 The European Research Journal Graves’ disease and thyroiditis can be differentiated using only free thyroid hormone levels %A Hilmi Erdem Sümbül , Fettah Acıbucu %T Graves’ disease and thyroiditis can be differentiated using only free thyroid hormone levels %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 4 %R doi: 10.18621/eurj.499174 %U 10.18621/eurj.499174