Year 2020, Volume 6 , Issue 5, Pages 373 - 379 2020-09-04

Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia

Halil Erkan SAYAN [1] , Vuslat MUSLU ERDEM [2] , Şefika Gülsen KORFALI [3]

Objectives: In this study, we aimed to evaluate the effects of isoflurane and sevoflurane on cerebral ischemia in patients undergoing intracranial tumour surgery by measuring protein S-100B in serum. Patients undergoing intracranial surgery are at risk for cerebral ischemia. The presence of S100-B in serum is an early and the most sensitive determinant of cerebral ischemia.

Methods: Twenty patients, scheduled for elective, intracranial tumor surgery were enrolled in this prospective and randomized study. Anaesthesia induction was performed with thiopental, fentanyl and vecuronium. In the maintenance, isoflurane or sevoflurane was administered in a minimum alveolar concentration of 0.8-1.2%. Peripheral blood samples were taken at 9 different times to measure protein S-100B levels.

Results: Demographic data, heart rate, systolic arterial pressure, mean arterial pressure and the deviations in the end-tidal carbon dioxide were similar in the study groups (p > 0.05), whereas diastolic arterial pressure was found to be significantly decreased in isoflurane group after the intubation, and there was an increase in the sevoflurane group (p < 0.05). Also there was no significant difference between the groups regarding protein S-100B levels.

Conclusions: It was concluded that isoflurane and sevoflurane have similar neuroprotective effects against cerebral ischemia and sevoflurane may be a good alternative to isoflurane. 


protein S-100B, intracranial tumor, inhalational anaesthetics
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Primary Language en
Subjects Anesthesiology
Journal Section Original Articles

Orcid: 0000-0003-3943-5549
Author: Halil Erkan SAYAN (Primary Author)
Institution: Department of Anesthesiology and Reanimation, University of Health Sciences , Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey

Orcid: 0000-0002-8903-9002
Author: Vuslat MUSLU ERDEM
Institution: Department of Anesthesiology and Intensive Care, Lütfiye Nuri Burat State Hospital, İstanbul, Turkey
Country: Turkey

Orcid: 0000-0001-7339-3122
Author: Şefika Gülsen KORFALI
Institution: Department of Anesthesiology and Reanimation, University of Health Sciences , Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Application Date : April 17, 2019
Acceptance Date : July 4, 2019
Publication Date : September 4, 2020

EndNote %0 The European Research Journal Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia %A Halil Erkan Sayan , Vuslat Muslu Erdem , Şefika Gülsen Korfalı %T Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 5 %R doi: 10.18621/eurj.554642 %U 10.18621/eurj.554642