Year 2020, Volume 6 , Issue 5, Pages 401 - 408 2020-09-04

The effect of teicoplanin coating on osteointegration of titanium screws: a biomechanical and histomorphometric study in a rabbit model

Ali ÇATALBAŞ [1] , Yavuz AKALIN [2] , İsmail Gökhan ŞAHİN [3] , Nazan ÇEVİK [4] , Yüksel ÖZKAN [5] , Alpaslan ÖZTÜRK [6]


Objectives: The aim of this experimental animal study was to make a biomechanical and histomorphometric evaluation of the effects of titanium screws covered with teicoplanin, which is wanted to prevent the development of infection, on osteointegration of the screw.

Methods: Twenty New Zealand white rabbits were randomly separated into 2 groups. In Group 1, 2 mini screws with teicoplanin coating were placed in the femoral condyles of the right knee and in Group 2, 2 mini screws with no coating. After 4 weeks, all the animals were sacrificed and prepared for biomechanical and histological examinations.

Results: In the pull-out test, the values of Group 1 were found to be higher and in the removal torque test, the values of Group 2 were higher. No positive correlation was found between the pull-out and removal torque tests (r = 0.88). The bone-implant contact value was found to be similar in both groups (p = 0.132).

Conclusions: The results showed that titanium screws with teicoplanin coating did not interfere with osteointegration process biomechanically andhistomorphometrically by comparison with screws having no coating so that teicoplanincoating can be considered for use in orthopedic devices and joint prosthesis to prevent the development of infection. 

teicoplanin, osteointegration, histomorphometry, biomechanics, titanium
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Primary Language en
Subjects Orthopedics
Journal Section Original Articles
Authors

Orcid: 0000-0002-1794-728X
Author: Ali ÇATALBAŞ
Institution: Department of Orthopaedics and Traumatology, Osmaniye State Hospital, Osmaniye, Turkey
Country: Turkey


Orcid: 0000-0001-7967-7054
Author: Yavuz AKALIN
Institution: Department of Orthopaedics and Traumatology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-6274-6102
Author: İsmail Gökhan ŞAHİN
Institution: Department of Orthopaedics and Traumatology, Sultan 1. Murat State Hospital, Edirne, Turkey
Country: Turkey


Orcid: 0000-0002-9596-8502
Author: Nazan ÇEVİK
Institution: Department of Orthopaedics and Traumatology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0001-6309-7346
Author: Yüksel ÖZKAN
Institution: Department of Orthopaedics and Traumatology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0001-7362-0284
Author: Alpaslan ÖZTÜRK (Primary Author)
Institution: Department of Orthopaedics and Traumatology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Dates

Application Date : August 2, 2019
Acceptance Date : March 5, 2020
Publication Date : September 4, 2020

EndNote %0 The European Research Journal The effect of teicoplanin coating on osteointegration of titanium screws: a biomechanical and histomorphometric study in a rabbit model %A Ali Çatalbaş , Yavuz Akalın , İsmail Gökhan Şahi̇n , Nazan Çevi̇k , Yüksel Özkan , Alpaslan Öztürk %T The effect of teicoplanin coating on osteointegration of titanium screws: a biomechanical and histomorphometric study in a rabbit model %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 5 %R doi: 10.18621/eurj.600539 %U 10.18621/eurj.600539