Year 2020, Volume 6 , Issue 5, Pages 517 - 526 2020-09-04

The relationship between prolactin and adipose tissue and metabolic parameters in patients with polycystic ovary syndrome

Gültekin ADANAS AYDIN [1] , Hilal Gülsm TURAN ÖZSOY [2]


Objectives: Polycystic ovary syndrome is a reproductive endocrinopathy, predominantly accompanied by insulin resistance, obesity, and metabolic disorder. In this study, we aimed to investigate the possible relationship between prolactin and adipose tissue and metabolic parameters in patients with polycystic ovary syndrome (PCOS).

Methods: A total of 58 patients with PCOS and 34 body mass index (BMI)-matched healthy controls between September 2018 and March 2019 were included in the study. Visceral and subcutaneous adipose tissues were measured using ultrasonography. Serum prolactin, fasting blood glucose, insulin, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, total cholesterol, luteinizing hormone (LH), total testosterone, dehydroepiandrosterone sulfate (DHEA-S), and 17-hydroxyprogesterone (17-OHP) levels were measured.

Results: The median BMI (p = 0.001), waist circumference (p = 0.002), hip circumference (p = 0.003), waist-to-hip ratio (p = 0.013), LH (p = 0.012), total testosterone (p = 0.004), DHEA-S (p = 0.049), 17-OHP (p = 0.001), insulin (p = 0.001), minimum preperitoneal fat thickness (p = 0.001), maximum preperitoneal fat thickness (p = 0.048), and intraperitoneal fat thickness (p = 0.018) were significantly higher in the PCOS group compared to the control group. However, there was no significant correlation between prolactin levels and adipose tissue parameters and insulin levels in the patients with PCOS.

Conclusions: Although there was an increase in the preperitoneal and intraperitoneal fat thickness in the PCOS group compared to the control group, no significant correlation was observed between prolactin and visceral and subcutaneous adipose tissues and metabolic parameters.

Prolactin, polycystic ovary syndrome, adipose tissue
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Primary Language en
Subjects Obstetrics and Gynecology
Journal Section Original Articles
Authors

Orcid: 0000-0002-9113-9846
Author: Gültekin ADANAS AYDIN (Primary Author)
Institution: Department of Obstetrics and Gynecology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0003-2021-6311
Author: Hilal Gülsm TURAN ÖZSOY
Institution: Department of Radiology, Bursa Çekirge Hospital, Bursa, Turkey
Country: Turkey


Dates

Application Date : December 31, 2019
Acceptance Date : May 6, 2020
Publication Date : September 4, 2020

EndNote %0 The European Research Journal The relationship between prolactin and adipose tissue and metabolic parameters in patients with polycystic ovary syndrome %A Gültekin Adanas , Hilal Gülsm Turan Özsoy %T The relationship between prolactin and adipose tissue and metabolic parameters in patients with polycystic ovary syndrome %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 5 %R doi: 10.18621/eurj.668471 %U 10.18621/eurj.668471