Research Article
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Year 2020, Volume: 6 Issue: 6, 600 - 608, 04.11.2020
https://doi.org/10.18621/eurj.550724

Abstract

References

  • 1. Hojsak I, Colomb V, Braegger C, Bronsky J, Campoy C, Domellöf M, et al. ESPGHAN committee on nutrition position paper. Intravenous lipid emulsions and risk of hepatotoxicity in infants and children: a systematic review and meta-analysis. J Pediatr Gastroenterol Nutr 2016;62:776-92.
  • 2. Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use. J Parenter Enter Nutr 2006;30:351-67.
  • 3. Mayer K, Gokorsch S, Fegbeutel C, Hattar K, Rosseau S, Walmrath D, et al.Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 2003;167:1321-8.
  • 4. Wanten GJA. Parenteral lipid tolerance and adverse effects: fat chance for trouble? JPEN J Parenter Enteral Nutr 2015;39:33-8.
  • 5. Mehta NM, Compher C. A.S.P.E.N. Clinical Guidelines: nutrition support of the critically ill child. JPEN J Parenter Enteral Nutr 2009;33:260-76.
  • 6. Beaufrere B. Eflicacite nutritionnelle et metabolique de ClinOleic 20%. Nutr Clin Metabol 1996;10:29-31.
  • 7. Goulet O, de Potter S, Antebi H, Driss F, Colomb V, Bereziat G, et al. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 1999;70:338-45.
  • 8. Shulman RJ, Phillips S. Parenteral nutrition in infants and children. J Pediatr Gastroenterol Nutr 2003;36:587-607.
  • 9. Oshita M, Takehara H, Yamaguchi M, Doi K, Ueda N, Naito S, et al.Significance of administration of fat emulsion: hepatic changes in infant rats receiving total parenteral nutrition with and without fat. Clin Nutr 2004;23:1060-8.
  • 10. Dahlström KA, Goulet OJ, Roberts RL, Ricour C, Ament ME. Lipid tolerance in children receiving long-term parenteral nutrition: a biochemical and immunologic study. J Pediatr 1988;113:985-90.
  • 11. Ythier-Moury P, Dutot G, Melin C. Modifications of biliary secretion associated with parenteral nutrition in the rat: influence of fat emulsion composition. Clin Nutr 1990;9:26.
  • 12. Calder PC. Lipids and the critically ill patient. Nestle Nutr Workshop Ser Clin Perform Programme 2003;8:75-91.
  • 13. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJA. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intens Care Med 2010;36:735-49.
  • 14. Goren A, Stankiewicz H, Goldstein R, Drukker A. Fish oil treatment of hyperlipidemia in children and adolescents receiving renal replacement therapy. Pediatrics 1991;88:265-8.
  • 15. Calkins KL, Dunn JCY, Shew SB, Reyen L, Farmer DG, Devaskar SU, et al. Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil. JPEN J Parenter Enteral Nutr 2014;38:682-92.
  • 16. Park Y, Harris WS. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res 2003;44:455-63.
  • 17. Leite HP, de Carvalho WB, Fisberg M. Nutritional and metabolic assessment of critically ill children. Sao Paulo Med J 1996;114:1156-61.
  • 18. Delgado AF, Kimura HM, Cardoso AL, Uehara D, Carrazza FR. Nutritional follow-up of critically ill infants receiving short term parenteral nutrition. Rev Hosp Clin Fac Med Sao Paulo 2000;55:3-8.
  • 19. Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA. Tocopherol and tocotrienol homologs in parenteral lipid emulsions. Eur J Lipid Sci Technol 2015;117:15-22.
  • 20. Pironi L, Guidetti M, Zolezzi C, Fasano MC, Paganelli F, Merli C, et al. Peroxidation potential of lipid emulsions after compounding in all-in-one solutions. Nutrition 2003;19:784-8.
  • 21. Pironi L, Guidetti M, Zolezzi C, Fasano MC, Paganelli F, Merli C, et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. JPEN J Parenter Enteral Nutr 2004;28:142-8.
  • 22. Wanten GJ, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr 2007;85:1171-84.
  • 23. Moussa M, Le Boucher J, Garcia J, Tkaczuk J, Ragab J, Dutot G, et al. In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr 2000;19:49-54.
  • 24. Granato D, Blum S, Rössle C, Le Boucher J, Malnoë A, Dutot G. Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr 2000;24:113-8.
  • 25. Puertollano MA, Puertollano E, Ruiz-Bravo A, Jiménez-Valera M, De Pablo MA, De Cienfuegos GA. Changes in the immune functions and susceptibility to Listeria monocytogenes infection in mice fed dietary lipids. Immunol Cell Biol 2004;82:370-6.
  • 26. Kumar GS, Das UN, Kumar KV, Madhavi N, Das NP, Tan BKH. Effect of n-6 and n-3 fatty acids on the proliferation of human lymphocytes and their secretion of TNF-α and IL-2 in vitro. Nutr Res 1992;12:815-23.
  • 27. Calder PC, Newsholme EA. Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin Sci 1992;82:695-700.
  • 28. Schauder P, Röhn U, Schäfer G, Korff G, Schenk HD. Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period. Br J Nutr 2002;87:103-10.
  • 29. Wu D, Meydani SN, Meydani M, Hayek MG, Huth P, Nicolosi RJ. Immunologic effects of marine- and plant-derived n-3 polyunsaturated fatty acids in nonhuman primates. Am J Clin Nutr 1996;63:273-80.
  • 30. Lapillonne A, Mis NF, Goulet O, van den Akker CH, Wu J, Koletzko B. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids. Clin Nutr 2018;37:2324-36.

A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children

Year 2020, Volume: 6 Issue: 6, 600 - 608, 04.11.2020
https://doi.org/10.18621/eurj.550724

Abstract

Objectives: Lipid emulsions are not only considered as a source of energy, but also as a regulatory substance for key metabolic functions in different diseases. The aim of the present study was to compare clinical, biochemical and immunological effects of olive oil, soybean oil and omega-3 fatty acid which are administrated to the children in parenteral nutrition products.

Methods: Patients who were admitted to pediatric intensive care unit and had parenteral nutrition for 7 days are included in the study. The patients were randomised into 3 groups based on the admission order, including 10 patients in each group. The children in Group O were fed by a lipid emulsion based on olive oil; the children in Group S were fed by a soybean based lipid emulsion and the children in group F were fed by soybean based lipid emulsion with omega-3 based solution. Analysis were made on the first and the seventh day. Laboratory parameters as well as hemogram, biochemical analysis, immunoglobulins, lymphocyte subgroup panel and cytokine levels were evaluated just before parenteral nutrition (day 0, basal value) and at day 7 of parenteral nutrition. Clinical monitoring parameters included body weight, and circumference of the mid-upper arm.

Results: Thirty children were enrolled into the study. Total cholesterol and triglyceride levels significantly increased in Group O whereas triglyceride level significantly increased in Group S. Hemogram, liver function tests, cytokine levels, lymphocyte sub-group distribution, immunoglobulin levels and total antioxidant capacity measurements were not different.

Conclusions: Three lipid emulsions which are used for parenteral nutrition treatment in intensive care unit patients are clinically and biochemically useful. 

References

  • 1. Hojsak I, Colomb V, Braegger C, Bronsky J, Campoy C, Domellöf M, et al. ESPGHAN committee on nutrition position paper. Intravenous lipid emulsions and risk of hepatotoxicity in infants and children: a systematic review and meta-analysis. J Pediatr Gastroenterol Nutr 2016;62:776-92.
  • 2. Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use. J Parenter Enter Nutr 2006;30:351-67.
  • 3. Mayer K, Gokorsch S, Fegbeutel C, Hattar K, Rosseau S, Walmrath D, et al.Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 2003;167:1321-8.
  • 4. Wanten GJA. Parenteral lipid tolerance and adverse effects: fat chance for trouble? JPEN J Parenter Enteral Nutr 2015;39:33-8.
  • 5. Mehta NM, Compher C. A.S.P.E.N. Clinical Guidelines: nutrition support of the critically ill child. JPEN J Parenter Enteral Nutr 2009;33:260-76.
  • 6. Beaufrere B. Eflicacite nutritionnelle et metabolique de ClinOleic 20%. Nutr Clin Metabol 1996;10:29-31.
  • 7. Goulet O, de Potter S, Antebi H, Driss F, Colomb V, Bereziat G, et al. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 1999;70:338-45.
  • 8. Shulman RJ, Phillips S. Parenteral nutrition in infants and children. J Pediatr Gastroenterol Nutr 2003;36:587-607.
  • 9. Oshita M, Takehara H, Yamaguchi M, Doi K, Ueda N, Naito S, et al.Significance of administration of fat emulsion: hepatic changes in infant rats receiving total parenteral nutrition with and without fat. Clin Nutr 2004;23:1060-8.
  • 10. Dahlström KA, Goulet OJ, Roberts RL, Ricour C, Ament ME. Lipid tolerance in children receiving long-term parenteral nutrition: a biochemical and immunologic study. J Pediatr 1988;113:985-90.
  • 11. Ythier-Moury P, Dutot G, Melin C. Modifications of biliary secretion associated with parenteral nutrition in the rat: influence of fat emulsion composition. Clin Nutr 1990;9:26.
  • 12. Calder PC. Lipids and the critically ill patient. Nestle Nutr Workshop Ser Clin Perform Programme 2003;8:75-91.
  • 13. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJA. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intens Care Med 2010;36:735-49.
  • 14. Goren A, Stankiewicz H, Goldstein R, Drukker A. Fish oil treatment of hyperlipidemia in children and adolescents receiving renal replacement therapy. Pediatrics 1991;88:265-8.
  • 15. Calkins KL, Dunn JCY, Shew SB, Reyen L, Farmer DG, Devaskar SU, et al. Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil. JPEN J Parenter Enteral Nutr 2014;38:682-92.
  • 16. Park Y, Harris WS. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res 2003;44:455-63.
  • 17. Leite HP, de Carvalho WB, Fisberg M. Nutritional and metabolic assessment of critically ill children. Sao Paulo Med J 1996;114:1156-61.
  • 18. Delgado AF, Kimura HM, Cardoso AL, Uehara D, Carrazza FR. Nutritional follow-up of critically ill infants receiving short term parenteral nutrition. Rev Hosp Clin Fac Med Sao Paulo 2000;55:3-8.
  • 19. Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA. Tocopherol and tocotrienol homologs in parenteral lipid emulsions. Eur J Lipid Sci Technol 2015;117:15-22.
  • 20. Pironi L, Guidetti M, Zolezzi C, Fasano MC, Paganelli F, Merli C, et al. Peroxidation potential of lipid emulsions after compounding in all-in-one solutions. Nutrition 2003;19:784-8.
  • 21. Pironi L, Guidetti M, Zolezzi C, Fasano MC, Paganelli F, Merli C, et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. JPEN J Parenter Enteral Nutr 2004;28:142-8.
  • 22. Wanten GJ, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr 2007;85:1171-84.
  • 23. Moussa M, Le Boucher J, Garcia J, Tkaczuk J, Ragab J, Dutot G, et al. In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr 2000;19:49-54.
  • 24. Granato D, Blum S, Rössle C, Le Boucher J, Malnoë A, Dutot G. Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr 2000;24:113-8.
  • 25. Puertollano MA, Puertollano E, Ruiz-Bravo A, Jiménez-Valera M, De Pablo MA, De Cienfuegos GA. Changes in the immune functions and susceptibility to Listeria monocytogenes infection in mice fed dietary lipids. Immunol Cell Biol 2004;82:370-6.
  • 26. Kumar GS, Das UN, Kumar KV, Madhavi N, Das NP, Tan BKH. Effect of n-6 and n-3 fatty acids on the proliferation of human lymphocytes and their secretion of TNF-α and IL-2 in vitro. Nutr Res 1992;12:815-23.
  • 27. Calder PC, Newsholme EA. Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin Sci 1992;82:695-700.
  • 28. Schauder P, Röhn U, Schäfer G, Korff G, Schenk HD. Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period. Br J Nutr 2002;87:103-10.
  • 29. Wu D, Meydani SN, Meydani M, Hayek MG, Huth P, Nicolosi RJ. Immunologic effects of marine- and plant-derived n-3 polyunsaturated fatty acids in nonhuman primates. Am J Clin Nutr 1996;63:273-80.
  • 30. Lapillonne A, Mis NF, Goulet O, van den Akker CH, Wu J, Koletzko B. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids. Clin Nutr 2018;37:2324-36.
There are 30 citations in total.

Details

Primary Language English
Subjects Paediatrics
Journal Section Original Articles
Authors

Salih Çağrı Çakır 0000-0001-5761-4757

Tanju Özkan 0000-0001-5740-9729

Taner Özgür 0000-0002-7528-9334

Publication Date November 4, 2020
Submission Date April 8, 2019
Acceptance Date February 4, 2020
Published in Issue Year 2020 Volume: 6 Issue: 6

Cite

AMA Çakır SÇ, Özkan T, Özgür T. A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. Eur Res J. November 2020;6(6):600-608. doi:10.18621/eurj.550724

e-ISSN: 2149-3189 


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