Year 2020, Volume 6 , Issue 6, Pages 609 - 614 2020-11-04

Evaluation of tear function tests and corneal thickness in patients with meibomian gland dysfunction

Kuddusi TEBERİK [1] , İlter İRİTAS [2]


Objectives: To investigate whether central corneal thickness (CCT) and tear function test differ from healthy controls in the ones suffering meibomian gland dysfunction (MGD). 

Methods: This prospective study was carried out with 99 individuals in total (50 patients MGD, 49 healthy individuals). Schirmer-1, tear break-up time (TBUT), the Ocular Surface Disease Index (OSDI) questionnaire and CCT measurmentwas administered to all patients.

Results: The average Schirmer 1 measurements were 16.6 ± 3.3 mm for right eyes, 16.4 ± 3.6 mm for left eyes in the MGD group and 17.1 ± 3.7 mm for right eyes, 17.0 ± 4.4 mm for left eyes in the control group. The mean TBUT values were 10.1 ± 3.6 seconds for right eyes, 10.2 ± 3.4 seconds for left eyes in the MGD group and 14.7±3.7 seconds for right eyes, 15.8 ± 4.1 seconds for left eyes in the control group (p = 0.001). The mean OSDI score values were 40.3 ± 23.7 in the MGD group and 19.4 ± 8.7 in the control group (p = 0.001). The average CCT in the MGD group was 539.4 ± 30.0 µm and 539.7 ± 33.0 µm (right and left, respectively). The average CCT in the control group was 551.6 ± 32.8 µm and 550.7 ± 32.2 µm (right and left, respectively). The mean CCT measurements in the MGD group were not statistically significant compared to the healthy control group (p = 0.059, and p = 0.097, right and left, respectively).

Conclusions: The Schirmer test and CCT measurements are not significantly different in patients with MGD compared to healthy control subjects. 

Meibomian gland dysfunction, Schirmer-1 test, tear break-up time, ocular surface disease index, central corneal thickness
  • 1. Greiner JV, Glonek T, Korb DR, Whalen AC, Hebert E, Hearn SL, et al. Volume of the human and rabbit meibomian gland system. In: Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Springer, Boston: MA; 1998: pp. 339-43.
  • 2. Mishima S, Maurice DM. The oily layer of the tear film and evaporation from the corneal surface. Exp Eye Res 1961;1:39-45.
  • 3. Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, et al. The international workshop on meibomian gland dysfunction: executive summary. Invest Ophthalmol Vis Sci 2011;52:1922-9.
  • 4. Bron AJ, Tiffany JM. The contribution of meibomian disease to dry eye. Ocul Surf 2004;2:149-65.
  • 5. Lemp MA, Nichols KK. Blepharitis in the United States, a survey-based perspective on prevalence and treatment. Ocul Surf 2009;7:1-14.
  • 6. Blackie CA, Korb DR, Knop E, Bedi R, Knop N, Holland EJ. Nonobvious obstructive meibomian gland dysfunction. Cornea 2010;29:1333-45.
  • 7. Nicolaides N, Kaitaranta JK, Rawdah TN, Macy JI, Boswell FM 3rd, Smith RE. Meibomian gland studies: comparison of steer and human lipids. Invest Ophthalmol Vis Sci 1981;20:522-36.
  • 8. Bron AJ, Benjamin L, Snibson GR. Meibomian gland disease. Classification and grading of lid changes. Eye (Lond) 1991;5:395-411.
  • 9. Driver PJ, Lemp MA. Meibomian gland dysfunction. Surv Ophthalmol 1996;40: 343-67.
  • 10. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci 2003;44:124-9.
  • 11. Pole JJ, Batzer JK. Central corneal thickness of patients with dry eyes. J Am Optom Assoc 1985;56:220-1.
  • 12. Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 2000;44:367-408.
  • 13. deSanctis U, Missolungi A, Mutani B, Richiardi L, Grignolo FM. Reproducibility and repeatability of central corneal thickness measurement in keratoconus using the rotating Scheimpflug camera and ultrasound pachymetry. Am J Ophthalmol 2007;144:712-8.
  • 14. Karadayi K, Ciftci F, Akin T, Bilge AH. Increase in central corneal thickness in dry and normal eyes with application of artificial tears: a new diagnostic and follow-up criterion for dry eye. Ophthalmic Physiol Opt 2005;25:485-91.
  • 15. Mathers WD. Ocular evaporation in meibomian gland dysfunction and dry eye. Ophthalmology 1993;100:347-51.
  • 16. Craig JP, Tomlinson A. Importance of the lipid layer in human tear film stability and evaporation. Optom Vis Sci 1997;74:8-13.
  • 17. Dayanir V, Sakarya R, Ozcura F, Kir E, Aktunç T, Ozkan BS, et al. Effect of corneal drying on central corneal thickness. J Glaucoma 2004;13:6-8.
  • 18. Taşkıran Cömez A, Tufan HA, Kocabıyık O, Gencer B. Effects of lubricating agents with different osmolalities on tear osmolarity and other tear function tests in patients with dry eye. Curr Eye Res 2013;38:1095-103.
  • 19. Korb DR, Hendriquez AS. Meibomian gland dysfunction and contact lens intolerance. J Am Optom Assoc 1980;51:243-51.
  • 20. Paugh JR, Knapp LL, Martinson JR, Hom MM. Meibomian therapy in problematic contact lens wear. Optom Vis Sci 1990;67:803-6.
  • 21. Akyol-Salman I, Azisi S, Mumcu U, Öndaş O, Baykal O. Central corneal thickness in patients with meibomian gland dysfunction. Clin Exp Optom 2011;94:464-7.
  • 22. Lee YG, Kim JH, Kim NR, Kim CY, Lee ES. Comparison between tonopachy and other tonometric and pachymetric devices. Optom Vis Sci 2011;88:843-9.
  • 23. Yuksel N, Ozer MD, Akcay E, Ozen U, Uzun S. Reduced central corneal thickness in patients with isotretinoin treatment. Cutan Ocul Toxicol 2015;34:318-21.
  • 24. Jackson WB.Blepharitis: current strategies for diagnosis and management. Can J Ophthalmol 2008;43:170-9.
  • 25. Sanchis-Gimeno JA, Lleo´-Pe´rez A, Alonso L, Rahhal MS, Martínez-Soriano F. Reduced corneal thickness values in postmenopausal women with dry eye. Cornea 2005;24:39-44.
  • 26. Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea 1999;18:403-7.
  • 27. van Bijsterveld OP, Baardman J. [Measurements of corneal thickness in patients with keratoconjunctivitis sicca]. Klin Monbl Augenheilkd 1990;197:240-3. [Article in German]
  • 28. Demircan A, Altan Ç, Azman FE, Alkin Z, Küçüksümer Y, Demirok A. [Tear properties in eyes with chronic blepharitis]. Turk J Ophthalmol 2012;42:346-348. [Article in Turkish]
  • 29. Sayman Muslubaş IB, Kahya A, Özertürk Y. [Tear function test results in patients with meibomian gland dysfunction]. J Kartal TR 2014;25:23-6. [Article in Turkish]
Primary Language en
Subjects Ophthalmology
Journal Section Original Articles
Authors

Orcid: 0000-0003-3141-0531
Author: Kuddusi TEBERİK (Primary Author)
Institution: Department of Ophthalmology, Düzce University School of Medicine, Düzce, Turkey
Country: Turkey


Orcid: 0000-0003-1789-4787
Author: İlter İRİTAS
Institution: Department of Ophthalmology, Ufuk University School of Medicine, Ankara, Turkey
Country: Turkey


Dates

Application Date : April 29, 2019
Acceptance Date : February 6, 2020
Publication Date : November 4, 2020

EndNote %0 The European Research Journal Evaluation of tear function tests and corneal thickness in patients with meibomian gland dysfunction %A Kuddusi Teberi̇k , İlter İri̇tas %T Evaluation of tear function tests and corneal thickness in patients with meibomian gland dysfunction %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 6 %R doi: 10.18621/eurj.558779 %U 10.18621/eurj.558779