Year 2021, Volume 7 , Issue 1, Pages 66 - 73 2021-01-04

Estrogen receptor expression in normal breast epithelium in invasive ductal carcinoma

Taşkın ERKİNÜRESİN [1] , Hakan DEMİRCİ [2] , Fügen VARDAR AKER [3]


Objectives: Invasive ductal carcinomas (IDCs) are the most important group of malignant breast tumors and constitute 75-80% of breast carcinomas. While IDCs often present with ductal carcinoma in situ (DCIS), they sometimes include a low level of DCIS or they do not include any accompanying DCIS at all. We planned this study to compare estrogen receptor (ER) expression levels in normal mammary epithelium in IDCs with extensive DCIS (Group I) and IDCs without DCIS (Group II).

Methods: Eighty IDC cases selected from among samples that were analyzed in our pathology laboratory. The cases were assessed retrospectively in light of immunohistochemical analysis results and pathology reports. Evaluation of immunohistochemistry: ER positivity in IDC was defined with a nuclear staining of more than 10% of cancer cells regardless of intensity of staining. Presence of cells showing nuclear staining for normal breast epithelium was classified in 4 groups according to their quantity and intensity. These were: 0-None: No staining was observed, 1-Single: One or two positive cells, 2-Dispersed: Dispersed positive cells surrounded by negative cells, 3-Adjoined: 10 or more positive cells contacting each other.

Results: Statistically no significant difference was found between Group I and Group II in terms of ER expression. Group I were more prevalent in younger and in the premenopausal period than Group II.

Conclusions: According to our study, there was no difference between Group I and Group II in terms of ER expression. But the significantly presence Group I in more young people and in premenopausal women suggests that these carcinomas develop due to high estrogen levels and that Group II develop independently than estrogen. This suggests that these groups may have different carcinogenesis and etiologies. We therefore think that this first study on IDCs with extensive DCIS and IDCs without DCIS should be supported by new research studies.

Estrogen reseptor, breast epithelium, invasive ductal carcinoma, ductal carcinoma in situ
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Primary Language en
Subjects Pathology
Journal Section Original Articles
Authors

Orcid: 0000-0003-1725-6590
Author: Taşkın ERKİNÜRESİN (Primary Author)
Institution: Department of Pathology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0003-0434-4807
Author: Hakan DEMİRCİ
Institution: Department of Family Medicine, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-7092-3391
Author: Fügen VARDAR AKER
Institution: Department of Pathology, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Bursa, İstanbul, Turkey
Country: Turkey


Dates

Application Date : May 6, 2019
Acceptance Date : January 6, 2020
Publication Date : January 4, 2021

EndNote %0 The European Research Journal Estrogen receptor expression in normal breast epithelium in invasive ductal carcinoma %A Taşkın Erki̇nüresi̇n , Hakan Demi̇rci̇ , Fügen Vardar Aker %T Estrogen receptor expression in normal breast epithelium in invasive ductal carcinoma %D 2021 %J The European Research Journal %P -2149-3189 %V 7 %N 1 %R doi: 10.18621/eurj.560939 %U 10.18621/eurj.560939