Year 2021, Volume 7 , Issue 1, Pages 38 - 43 2021-01-04

Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors

Aslıhan DEMİREL [1] , Kezban NUR PİLANCI [2] , Neşe İNAN [3] , Nur Efe İRİS [4] , Arzu BAYGÜL [5] , Gökhan DEMİR [6] , Emine SÖNMEZ [7]


Objectives: Chemotherapy induces an immunosuppressive state in patients with solid organ tumors. Cytomegalovirus (CMV) reactivation as a result of immunosuppression causes a severe clinical manifestation. However, in this group, CMV infections developing due to reactivation were not adequately discussed in the literature. The aims of this study were to determine the incidence of CMV reactivation after chemotherapy, to evaluate the contribution of chemotherapy to reactivation, to determine the incidence of asymptomatic and symptomatic infections and to investigate the results of the treatment.

Methods: A total of 93 patients with solid tumors were included in the study. Weekly blood samples were collected from the patients for three weeks before and after chemotherapy. Quantitative analysis of DNA was detected using CMV PCR kit (GeneProof CMV PCR kit, Bruno, Czech Republic). Diagnosis and treatment of patients were retrospectively reviewed.

Results: Of the patients, 65.6% were female and 34.4% were male. The mean age was 55 ± 12 years. The most common cancer types among the patients were breast cancer in 45.2%, lung cancer in 15.1%, and colon cancer in 12.9%. The mean leukocyte count of the patients was 7,647/mm3. CMV DNA was not detected in any patient. According to this result, none of the patients had CMV reactivation after chemotherapy. 

Conclusions: In this study including patients with solid organ tumors with mild to moderate level of immunosuppression CMV DNA was not detected in any patient. Based on this finding no standard prophylaxis was required for CMV in this group of patients.

Cytomegalovirus, solid organ tumor, chemotherapy
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Primary Language en
Subjects Infectious Diseases
Journal Section Original Articles
Authors

Orcid: 0000-0001-6309-1809
Author: Aslıhan DEMİREL (Primary Author)
Institution: Department of Infectious Diseases and Clinical Microbiology, Kadıköy Florence Nightingale Hospital, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0002-0901-819X
Author: Kezban NUR PİLANCI
Institution: Department of Medical Oncology, İstanbul Aydın University School of Medicine, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0002-1559-6244
Author: Neşe İNAN
Institution: Department of Microbiology, TOBB ETU Hospital, Ankara, Turkey
Country: Turkey


Orcid: 0000-0001-6725-5188
Author: Nur Efe İRİS
Institution: Department of Infectious Diseases and Clinical Microbiology, İstanbul Bilim University School of Medicine, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0002-4859-0009
Author: Arzu BAYGÜL
Institution: Department of Biostatistics and Medical Informatics, Beykent University School of Medicine, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0001-6725-5188
Author: Gökhan DEMİR
Institution: Department of Medical Oncology, Acıbadem University School of Medicine, İstanbul, Turkey
Country: Turkey


Orcid: 0000-0002-5913-1019
Author: Emine SÖNMEZ
Institution: Department of Infectious Diseases and Clinical Microbiology, Beykent University School of Medicine, İstanbul, Turkey
Country: Turkey


Supporting Institution No
Project Number No
Dates

Application Date : June 10, 2019
Acceptance Date : January 31, 2020
Publication Date : January 4, 2021

EndNote %0 The European Research Journal Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors %A Aslıhan Demi̇rel , Kezban Nur Pi̇lancı , Neşe İnan , Nur Efe İri̇s , Arzu Baygül , Gökhan Demi̇r , Emine Sönmez %T Investigation of the effect of chemotherapy on cytomegalovirus reactivity in patients with solid organ tumors %D 2021 %J The European Research Journal %P -2149-3189 %V 7 %N 1 %R doi: 10.18621/eurj.573407 %U 10.18621/eurj.573407