Year 2021, Volume 7 , Issue 2, Pages 142 - 151 2021-03-04

Comparison of the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery

Vuslat MUSLU ERDEM [1] , Halil Erkan SAYAN [2] , Sefika Gulsen KORFALİ [3]

Objectives: Surgeries can trigger stress responses including metabolic and hormonal changes. It is important to suppress stress response during surgery. We compared the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery.

Methods: Thirty ASA physical status I, II, III patients, scheduled for elective craniotomies, were enrolled in this prospective, randomized study. Anesthesia was induced with sodium thiopental fentanyl and vecuronium bromide and maintained with a 50% oxygen-air mixture along with isoflurane or sevoflurane. Venous blood was sampled to measure cortisol, ACTH and prolactin levels 24 hours before surgery, 1 min before anesthesia induction, during tumor removal, 1 min after extubation, at 3, 6, 12, 24, 48 hours.

Results: There was no statistically significant difference between two groups regarding demographic characteristics of patients. In group I, ACTH levels were significantly higher 1 min after extubation, at 3 and 6 hours. In Group S, significant increases were observed during tumor removal, 1 min after extubation, at 3 and 6 hours. Cortisol levels were significantly higher in both group after tumor removal, 1 min after extubation, at 3, 6, 12 and 24 hours. Prolactin levels were significantly higher in Group I during tumor removal, after extubation, at 3 and 6 hours. In group S, significant increase in prolactin level was observed only during tumor removal and 1 min after extubation. There were no significant differences in ACTH, cortisol and prolactin values between the two groups.

Conclusions: Using isoflurane or sevoflurane for anesthesia during intracranial tumor surgery are not superior to each other regarding hemodynamic and hormonal stress response.

surgical stress, isoflurane, sevoflurane, catecholamines, ACTH, cortisol
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Primary Language en
Subjects Anesthesiology
Journal Section Original Articles

Orcid: 0000-0002-8903-9002
Author: Vuslat MUSLU ERDEM
Institution: Department of Anesthesiology and Reanimation, Lütfiye Nuri Burat State Hospital, İstanbul, Turkey
Country: Turkey

Orcid: 0000-0003-3943-5549
Author: Halil Erkan SAYAN
Institution: Department of Anesthesiology and Reanimation, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey

Orcid: 0000-0001-7339-3122
Author: Sefika Gulsen KORFALİ
Institution: Department of Anesthesiology and Reanimation, Uludağ University School of Medicine, Bursa, Turkey
Country: Turkey


Application Date : November 20, 2019
Acceptance Date : July 11, 2020
Publication Date : March 4, 2021

EndNote %0 The European Research Journal Comparison of the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery %A Vuslat Muslu Erdem , Halil Erkan Sayan , Sefika Gulsen Korfali %T Comparison of the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery %D 2021 %J The European Research Journal %P -2149-3189 %V 7 %N 2 %R doi: 10.18621/eurj.648843 %U 10.18621/eurj.648843