Year 2021, Volume 7 , Issue 3, Pages 225 - 234 2021-05-04

Serum undercarboxylated osteocalcin levels are related to bone disease in hemodialysis and peritoneal dialysis patients

Medine ALPDEMİR [1] , Vildan FİDANCI [2] , Mehmet Fatih ALPDEMİR [3] , Alper AZAK [4] , Gülsevim SAYDAM [5] , Murat DURANAY [6] , Doğan YÜCEL [7]


Objectives: In our study, we investigated whether the undercarboxylated osteocalcin (ucOC) is an indicator of bone turnover for patients treated with hemodialysis (HD) or peritoneal dialysis (PD). Furthermore, we have examined the relationships between ucOC levels and other bone inidicators such as osteocalcin (OC), bone specific alkaline phosphatase (B-ALP), calcitonin, vitamin D, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), magnesium (Mg) and bone mineral density (BMD).

Methods: Study group was consisted of 24 HD, 30 PD patients and 30 control subjects. ucOC measurements were based on precipitation of carboxylated OC with barium sulfate. After precipitation, ucOC was measured in supernatant by ELISA.

Results: In chronic kidney disease (CKD), increased ucOC levels were present both in HD and PD groups. The ucOC levels in HD group were higher than those of PD group. ucOC levels in samples after HD were lower than in samples before HD. But there is no difference between groups for ucOC% levels. We observed that ucOC levels for CRF were higher compared to that of control group and statistically significant. ucOC levels were positively correlated with OC, B-ALP, ALP, iPTH, P and Mg levels. There were negative and significant correlations between ucOC levels and BMD values. ucOC has a good discrimination power for both high and low turnover ROD groups.

Conclusions: ucOC is a useful marker to evaluation of bone metabolism in patients undergone hemodialysis or peritoneal dialysis in end-stage renal disease.

Renal bone disease, Hemodialysis, Peritoneal dialysis, Undercarboxylated osteocalcin, Osteocalcin, Bone mineral density
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Primary Language en
Subjects Biochemistry and Molecular Biology, General and Internal Medicine
Journal Section Original Articles
Authors

Orcid: 0000-0003-2625-0246
Author: Medine ALPDEMİR (Primary Author)
Institution: Department of Clinical Biochemistry, Balıkesir State Hospital, Balıkesir, Turkey
Country: Turkey


Orcid: 0000-0003-0057-279X
Author: Vildan FİDANCI
Institution: Department of Clinical Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey
Country: Turkey


Orcid: 0000-0003-3015-1478
Author: Mehmet Fatih ALPDEMİR
Institution: Department of Clinical Biochemistry, Balıkesir State Hospital, Balıkesir, Turkey
Country: Turkey


Orcid: 0000-0001-6228-8829
Author: Alper AZAK
Institution: Department of Nephrology, Balıkesir Atatürk City Hospital, Balıkesir, Turkey
Country: Turkey


Orcid: 0000-0003-3387-4866
Author: Gülsevim SAYDAM
Institution: Department of Clinical Biochemistry, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Country: Turkey


Orcid: 0000-0002-2893-4484
Author: Murat DURANAY
Institution: Department of Nephrology, Ankara Training and Research Hospital, Ankara, Turkey
Country: Turkey


Orcid: 0000-0001-5487-2857
Author: Doğan YÜCEL
Institution: Department of Clinical Biochemistry, Ankara Training and Research Hospital, Ankara, Turkey
Country: Turkey


Dates

Application Date : August 20, 2020
Acceptance Date : December 18, 2020
Publication Date : May 4, 2021

EndNote %0 The European Research Journal Serum undercarboxylated osteocalcin levels are related to bone disease in hemodialysis and peritoneal dialysis patients %A Medine Alpdemir , Vildan Fidancı , Mehmet Fatih Alpdemir , Alper Azak , Gülsevim Saydam , Murat Duranay , Doğan Yücel %T Serum undercarboxylated osteocalcin levels are related to bone disease in hemodialysis and peritoneal dialysis patients %D 2021 %J The European Research Journal %P -2149-3189 %V 7 %N 3 %R doi: 10.18621/eurj.734216 %U 10.18621/eurj.734216