Research Article
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Year 2022, Volume: 8 Issue: 4, 442 - 449, 04.07.2022
https://doi.org/10.18621/eurj.1083732

Abstract

References

  • 1. Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med 2018;198:e44-e68.
  • 2. Kaarteenaho R. The current position of surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis. Respir Res 2013;14:43-52.
  • 3. Watadani T, Sakai F, Johkoh T, Noma S, Akira M, Fujimoto K, et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology 2013;266:936-44.
  • 4. Zavaletta VA, Bartholmai BJ, Robb RA. High resolution multidetector CT-aided tissue analysis and quantification of lung fibrosis. Acad Radiol 2007;14:772-87.
  • 5. Bartholmai BJ, Raghunath S, Karwoski RA, Moua T, Rajagopalan S, Maldonado F, et al. Quantitative computed tomography imaging of interstitial lung diseases. J Thorac Imaging 2013;28:298-307.
  • 6. Han MK, Murray S, Fell CD, Flaherty KR, Toews GB, Myers J, et al. Sex differences in physiological progression of idiopathic pulmonary fibrosis. Eur Respir J 2008;31:1183-8.
  • 7. Kalafatis D, Gao J, Pesonen I, Carlson L, Sköld CM, Ferrara G. Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden. BMC Pulm Med 2019;19:222-9.
  • 8. Furini F, Carnevale A, Casoni GL, Guerrini G, Cavagna L, Govoni M, et al. The role of the multidisciplinary evaluation of interstitial lung diseases: systematic literature review of the current evidence and future perspectives. Front Med (Lausanne) 2019;6:246-62.
  • 9. Travis WD, Costabel U, Hansell DM, King TEJ, Lynch DA, Nicholson AG, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2013;188:733-48.
  • 10. Maldonado F, Moua T, Rajagopalan S, Karwoski RA, Raghunath S, Decker PA, et al. Automated quantification of radiological patterns predicts survival in idiopathic pulmonary fibrosis. Eur Respir J 2014;43:204-12.
  • 11. Iwasawa T, Ogura T, Sakai F, Kanauchi T, Komagata T, Baba T, et al. CT analysis of the effect of pirfenidone in patients with idiopathic pulmonary fibrosis. Eur J Radiol 2014;83:32-8.
  • 12. Raghunath S, Moua T, Segovis C, Maldonado F, Ryu J, Decker P, et al. Correlation of quantitative lung tissue characterization as assessed by CALIPER with pulmonary function and 6-minute walk test [abstract]. Chest 2011;140 (4_MeetingAbstracts):1040A.
  • 13. Jacob J, Bartholmai BJ, Egashira R, Brun AL, Rajagopalan S, Karwoski R, et al. Automated quantitative computed tomography versus visual computed tomography scoring in idiopathic pulmonary fibrosis. J Thorac Imaging 2016;31:304-11.

Comparison of quantitative lung computed tomographic findings between idiopathic pulmonary fibrosis patients diagnosed by biopsy and by multidisciplinary discussion without biopsy

Year 2022, Volume: 8 Issue: 4, 442 - 449, 04.07.2022
https://doi.org/10.18621/eurj.1083732

Abstract

Objectives: We aimed to investigate the objective quantitative differences between the parenchymal computed tomography (CT) findings of idiopathic pulmonary fibrosis (IPF) patients diagnosed by surgical lung biopsy and by multidisciplinary discussion without biopsy.


Methods:
We performed parenchymal texture analyses in lung CT images of 116 IPF patients, 42 diagnosed by surgical lung biopsy, and 74 by multidisciplinary discussion without biopsy. The relative volumes of the ground-glass, reticular, honeycomb, hyperlucent, and normal parenchymal patterns were measured in six predefined sections of each lung by an automatic texture analysis software (CALIPER: Computer-Aided Lung Informatics for Pathology Evaluation and Rating). The results were compared between the two patient groups.

Results: When the relative volumes of the parenchymal patterns were compared between the biopsied and non-biopsied groups in a total lung-based manner, the mean percentage of only the ground-glass pattern was significantly higher in the biopsied group. When compared between the corresponding lung sections, the percentages of the ground-glass pattern were higher in the biopsied group than those in the non-biopsied group at the bilateral central sections of the upper, middle, and lower lung zones. At the bilateral peripheral sections of the middle and lower lung zones, the sectional reticular pattern percentages were lower in the biopsied group than those in the non-biopsied group.


Conclusions:
CALIPER’s quantitative CT measurements revealed that the sectional relative volumes of the ground-glass and reticular patterns, but not of the honeycomb, normal, and hyperlucent parenchyma, were significantly different between some of the corresponding lung sections of the biopsied and non-biopsied IPF patients. This information may help a better understanding of the role of the CT findings in biopsy decisions and avoiding some of the unnecessary biopsies in suspected IPF patients.

References

  • 1. Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med 2018;198:e44-e68.
  • 2. Kaarteenaho R. The current position of surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis. Respir Res 2013;14:43-52.
  • 3. Watadani T, Sakai F, Johkoh T, Noma S, Akira M, Fujimoto K, et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology 2013;266:936-44.
  • 4. Zavaletta VA, Bartholmai BJ, Robb RA. High resolution multidetector CT-aided tissue analysis and quantification of lung fibrosis. Acad Radiol 2007;14:772-87.
  • 5. Bartholmai BJ, Raghunath S, Karwoski RA, Moua T, Rajagopalan S, Maldonado F, et al. Quantitative computed tomography imaging of interstitial lung diseases. J Thorac Imaging 2013;28:298-307.
  • 6. Han MK, Murray S, Fell CD, Flaherty KR, Toews GB, Myers J, et al. Sex differences in physiological progression of idiopathic pulmonary fibrosis. Eur Respir J 2008;31:1183-8.
  • 7. Kalafatis D, Gao J, Pesonen I, Carlson L, Sköld CM, Ferrara G. Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden. BMC Pulm Med 2019;19:222-9.
  • 8. Furini F, Carnevale A, Casoni GL, Guerrini G, Cavagna L, Govoni M, et al. The role of the multidisciplinary evaluation of interstitial lung diseases: systematic literature review of the current evidence and future perspectives. Front Med (Lausanne) 2019;6:246-62.
  • 9. Travis WD, Costabel U, Hansell DM, King TEJ, Lynch DA, Nicholson AG, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2013;188:733-48.
  • 10. Maldonado F, Moua T, Rajagopalan S, Karwoski RA, Raghunath S, Decker PA, et al. Automated quantification of radiological patterns predicts survival in idiopathic pulmonary fibrosis. Eur Respir J 2014;43:204-12.
  • 11. Iwasawa T, Ogura T, Sakai F, Kanauchi T, Komagata T, Baba T, et al. CT analysis of the effect of pirfenidone in patients with idiopathic pulmonary fibrosis. Eur J Radiol 2014;83:32-8.
  • 12. Raghunath S, Moua T, Segovis C, Maldonado F, Ryu J, Decker P, et al. Correlation of quantitative lung tissue characterization as assessed by CALIPER with pulmonary function and 6-minute walk test [abstract]. Chest 2011;140 (4_MeetingAbstracts):1040A.
  • 13. Jacob J, Bartholmai BJ, Egashira R, Brun AL, Rajagopalan S, Karwoski R, et al. Automated quantitative computed tomography versus visual computed tomography scoring in idiopathic pulmonary fibrosis. J Thorac Imaging 2016;31:304-11.
There are 13 citations in total.

Details

Primary Language English
Subjects Respiratory Diseases, Radiology and Organ Imaging
Journal Section Original Articles
Authors

Atila Gökçek 0000-0002-5378-5871

Publication Date July 4, 2022
Submission Date March 7, 2022
Acceptance Date April 21, 2022
Published in Issue Year 2022 Volume: 8 Issue: 4

Cite

AMA Gökçek A. Comparison of quantitative lung computed tomographic findings between idiopathic pulmonary fibrosis patients diagnosed by biopsy and by multidisciplinary discussion without biopsy. Eur Res J. July 2022;8(4):442-449. doi:10.18621/eurj.1083732

e-ISSN: 2149-3189 


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