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Year 2023, Volume: 9 Issue: 1, 66 - 72, 04.01.2023
https://doi.org/10.18621/eurj.1134577

Abstract

References

  • 1. Akiba J, Ueno N, Chakrabarti B. Age-related changes in the molecular properties of vitreous collagen. Curr Eye Res 1993;12:951-4.
  • 2. Akiba J, Ueno N, Chakrabarti B. Mechanisms of photo-induced vitreous liquefaction. Curr Eye Res 1994;13:505-12.
  • 3. Murthy KR, Goel R, Subbannayya Y, Jacob HK, Murthy PR, Mandal SS, et al. Proteomic analysis of human vitreous humor. Clin Proteomics 2014;11:29.
  • 4. Funatsu H, Yamashita H, Noma H, Mimura T, Nakamura S, Sakata K, et al. Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp Ophthalmol 2005;243:3-8.
  • 5. Ginat DT, Meyers SP. Intracranial lesions with high signal intensity on T1-weighted MR images: differential diagnosis. RadioGraphics 2012;32:499-516.
  • 6. Itakura H, Kishi S, Kotajima N, Murakami M. Decreased vitreal hyaluronan levels with aging. Ophthalmologica 2009;223:32-5.
  • 7. Duke-Elder SS. The nature of the vitreous body. G. Pulman & Sons, Limited, 1930.
  • 8. Sebag J. Imaging vitreous. Eye 2002;16:429-39.
  • 9. Sebag J. Age-related changes in human vitreous structure. Graefes Arch Clin Exp Ophthalmol 1987;225:89-93.
  • 10. Balazs E, Flood M. Age-related changes in the physical and chemical structure of human vitreous. Third International Congress of Eye Research, Osaka, Japan, 1978.
  • 11. Los LI, van der Worp RJ, van Luyn MJA, Hooymans JMM. Age-related liquefaction of the human vitreous body: LM and TEM evaluation of the role of proteoglycans and collagen. Invest Ophthalmol Vis Sci 2003;44:2828-33.
  • 12. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res 2000;19:323-44.
  • 13. Sebag J. To see the invisible: the quest of imaging vitreous. Dev Ophthalmol 2008;42:5-28.
  • 14. Malhotra A, Minja FJ, Crum A, Burrowes D. Ocular anatomy and cross-sectional imaging of the eye. Semin Ultrasound CT MRI 2011;32:2-13.
  • 15. Küpeli A, Koçak M, Danışan D, Soytürk M. [Evaluation of vitreous humor changes associated with aging by diffusion MRI]. Sakarya Med J 2019;9:266-71.
  • 16. Meral İ, Bilgili Y. Diffusion changes in the vitreous humor of the eye during aging. Am J Neuroradiol 2011;32:1563-6.

Evaluation of age-related changes in the vitreous using magnetic resonance imaging

Year 2023, Volume: 9 Issue: 1, 66 - 72, 04.01.2023
https://doi.org/10.18621/eurj.1134577

Abstract

Objectives: Age-related liquefaction of vitreous humor may result in posterior vitreous detachment, retinal tear, and detachment. The purpose of this study is to determine the normative values of age-related changes in the vitreous in the normal population using different MRI sequences.


Methods:
A total of 180 eyes of 90 healthy cases were enrolled in this retrospective study. Patients were divided into nine groups according to age, and each group was of equal size with 10 patients(5 male and 5 female). The T1, T2, standardized T1, standardized T2 signals and ADC values determined for each vitreous humor of each eye. MRI parameters of the vitreous were compared within and between age groups.


Results:
No difference was detected within the decadic age groups for mean T1W for the right and left (p = 0.912 and p = 0.903, respectively), T2W for the right and left (p = 0.966 and p = 0.983, respectively), standardized T2W for the right and left (p = 0.915 and p = 0.899, respectively), and ADC for right and left values (p = 0.622 and p = 0.524, respectively). A significant difference was found between decadic age groups in terms of the standardized T1W values for right and left (p < 0.001 and p < 0.001, respectively). Standardized T1W values of vitreous fluid show a moderate degree of correlation with age for the right (r=0.514, p < 0.001) and left eyes (r=0.534, p < 0.001).


Conclusions:
This study provides comprehensive normative data on the different MRI signal properties of the human vitreous and its change with age. Using MRI, especially with standardized T1 measurements, age-related changes in the vitreous humor can be revealed non-invasively.

References

  • 1. Akiba J, Ueno N, Chakrabarti B. Age-related changes in the molecular properties of vitreous collagen. Curr Eye Res 1993;12:951-4.
  • 2. Akiba J, Ueno N, Chakrabarti B. Mechanisms of photo-induced vitreous liquefaction. Curr Eye Res 1994;13:505-12.
  • 3. Murthy KR, Goel R, Subbannayya Y, Jacob HK, Murthy PR, Mandal SS, et al. Proteomic analysis of human vitreous humor. Clin Proteomics 2014;11:29.
  • 4. Funatsu H, Yamashita H, Noma H, Mimura T, Nakamura S, Sakata K, et al. Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp Ophthalmol 2005;243:3-8.
  • 5. Ginat DT, Meyers SP. Intracranial lesions with high signal intensity on T1-weighted MR images: differential diagnosis. RadioGraphics 2012;32:499-516.
  • 6. Itakura H, Kishi S, Kotajima N, Murakami M. Decreased vitreal hyaluronan levels with aging. Ophthalmologica 2009;223:32-5.
  • 7. Duke-Elder SS. The nature of the vitreous body. G. Pulman & Sons, Limited, 1930.
  • 8. Sebag J. Imaging vitreous. Eye 2002;16:429-39.
  • 9. Sebag J. Age-related changes in human vitreous structure. Graefes Arch Clin Exp Ophthalmol 1987;225:89-93.
  • 10. Balazs E, Flood M. Age-related changes in the physical and chemical structure of human vitreous. Third International Congress of Eye Research, Osaka, Japan, 1978.
  • 11. Los LI, van der Worp RJ, van Luyn MJA, Hooymans JMM. Age-related liquefaction of the human vitreous body: LM and TEM evaluation of the role of proteoglycans and collagen. Invest Ophthalmol Vis Sci 2003;44:2828-33.
  • 12. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res 2000;19:323-44.
  • 13. Sebag J. To see the invisible: the quest of imaging vitreous. Dev Ophthalmol 2008;42:5-28.
  • 14. Malhotra A, Minja FJ, Crum A, Burrowes D. Ocular anatomy and cross-sectional imaging of the eye. Semin Ultrasound CT MRI 2011;32:2-13.
  • 15. Küpeli A, Koçak M, Danışan D, Soytürk M. [Evaluation of vitreous humor changes associated with aging by diffusion MRI]. Sakarya Med J 2019;9:266-71.
  • 16. Meral İ, Bilgili Y. Diffusion changes in the vitreous humor of the eye during aging. Am J Neuroradiol 2011;32:1563-6.
There are 16 citations in total.

Details

Primary Language English
Subjects Radiology and Organ Imaging
Journal Section Original Articles
Authors

Beyza Nur Kuzan 0000-0002-5001-3649

Taha Yusuf Kuzan 0000-0002-5420-8507

Onur Buğdaycı 0000-0002-6011-2720

Publication Date January 4, 2023
Submission Date June 23, 2022
Acceptance Date August 20, 2022
Published in Issue Year 2023 Volume: 9 Issue: 1

Cite

AMA Kuzan BN, Kuzan TY, Buğdaycı O. Evaluation of age-related changes in the vitreous using magnetic resonance imaging. Eur Res J. January 2023;9(1):66-72. doi:10.18621/eurj.1134577

e-ISSN: 2149-3189 


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