Primary bone diffuse B cell lymphoma of the thoracic spine: a rare entity

Year 2023, Volume: 9 Issue: 3, 600 - 604, 04.05.2023

Emrah Akçay Hüseyin Berk Benek Hakan Yılmaz Alper Tabanlı Alaattin Yurt

https://doi.org/10.18621/eurj.1153678

Abstract

Primary bone lymphoma is a rare entity, accounting for approximately 3-7% of malignant bone tumors, 5% of extra-nodal lymphomas and <1% of all non-Hodgkin lymphomas. Primary spine localized lymphoma is 1.7% of all primary bone lymphomas.
A 73 year-old female presented with a two month history of severe backache. T1W and T2W MRI showed a hypointense soft tissue component extending from the left posterior elements to Th7 corpus. The patient underwent Th6-7-8 total laminectomy. Th7-8 extradural mass was totally resected. Excisional biopsy was performed through Th7 left pedicle and vertebroplasty was applied. Significant reduction in pain was seen postoperatively. The patient was diagnosed with diffuse large B cell lymphoma. R-CHOP chemotherapy and local radiotherapy were applied. Any other lesions were not detected after the examinations following 6 months period and it was accepted as primary bone lymphoma.

Keywords

Primary bone lymphoma, diffuse large B cell lymphoma, thoracic spine, excisional biopsy, vertebroplasty

References

• 1. Jia P, Li JJ, Chen H, Bao L, Feng F, Tang H. Percutaneous vertebroplasty for primary non-Hodgkin’s lymphoma of the thoracic spine: case report and review of the literature. Pain Physician 2017;20:E727-35.
• 2. Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia 2022;36:1720-48.
• 3. Beal K, Allen L, Yahalom J. Primary bone lymphoma: treatment results and prognostic factors with long-term follow-up of 82 patients. Cancer 2006;106:2652-6.
• 4. Ramadan KM, Shenkier T, Sehn LH, Gaycoyne RD, Connors JM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol 2007;18:129-35.
• 5. Ahmadi SA, Frank S, Hanggi D, Eicker SO. Primary spinal marginal zone lymphoma:Case report and review of the literature. Neurosurgery 2012;71:E495-508.
• 6. Messina C, Christie D, Zucca E, Gospodarowicz M, Ferreri AJ. Primary and secondary bone lymphomas. Cancer Treat Rev 2015;41:235-46.
• 7. Undabeitia J, Noboa R, Boix M, Garcia T, Panades MJ, Nogues P. Primary bone non-Hodgkin lymphoma of the cervical spine: case report and review. Turk Neurosurg 2014;24:438-42.
• 8. Paes FM, Kalkanis DG, Sideras PA, Serafini AN. FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics 2010;30:269-91.
• 9. Fidias P, Spiro I, Sobczak ML, Nielsen GP, Ruffolo EF, Mankin H, et al. Long-term results of combined modality therapy in primary bone lymphomas. Int J Radiat Oncol Biol Phys 1999;45:1213-8.
• 10. Kaifa G, Didangelos T, Bobos M, Karlafti E, Ztriva E, Kanellos I, et al. Primary bone diffuse large B-cell lymphoma with multifocal osteolytic lesions: a rare entity. Gen Med (Los Angeles) 2018;6:1-3.
• 11. Zhang X, Chang CK, Song LX, Xu L, Wu LY, Li X. Primary lymphoma of bone: a case report and review of the literature. Med Oncol 2011;28:202-6.