Research Article
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Year 2023, Volume: 9 Issue: 4, 674 - 679, 04.07.2023
https://doi.org/10.18621/eurj.1038532

Abstract

References

  • 1. Macle L, Cairns J, Leblanc K, Tsang T, Skanes A, Cox JL, et al. 2016 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. Can J Cardiol 2016;32:1170-85.
  • 2. Ali-Hassan-Sayegh S, Mirhosseini SJ, Rezaeisadrabadi M, Dehghan HR, Sedaghat-Hamedani F, Kayvanpour E, et al. Antioxidant supplementations for prevention of atrial fibrillation after cardiac surgery: An updated comprehensive systematic review and meta-analysis of 23 randomized controlled trials. Interact Cardiovasc Thorac Surg 2014;18:646-54.
  • 3. Weymann A, Ali-Hasan-Al-Saegh S, Sabashnikov A, Popov AF, Mirhosseini SJ, Liu T, et al. Prediction of new-onset and recurrent atrial fibrillation by complete blood count tests: a comprehensive systematic review with meta-analysis. Med Sci Monit Basic Res 2017;23:179-222.
  • 4. Çınar T, Çağdaş M, Rencüzoğulları İ, Karakoyun S, Karabağ Y, Yesin M, et al. Prognostic efficacy of C-reactive protein/albumin ratio in ST elevation myocardial infarction. Scand Cardiovasc J 2019;53:83-90.
  • 5. Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J Am Coll Cardiol 2011;57:e101-98.
  • 6. Asselbergs FW, van den Berg MP, Diercks GF, van Gilst WH, van Veldhuisen DJ. C-reactive protein and microalbuminuria are associated with atrial fibrillation. Int J Cardiol 2015;98:73-7.
  • 7. Aronson D, Boulos M, Suleiman A, Bidoosi S, Agmon Y, Kapeliovich M, et al. Relation of C-reactive protein and new-onset atrial fibrillation in patients with acute myocardial infarction. Am J Cardiol 2007;100:753-7.
  • 8. Mukamal KJ, Tolstrup JS, Friberg J, Grønbaek M, Jensen G. Fibrinogen and albumin levels and risk of atrial fibrillation in men and women (the Copenhagen City Heart Study). Am J Cardiol 2006;98:75-81.
  • 9. Kelesoglu S, Yilmaz Y, Ozkan E, Calapkorur B, Dursun ZB, Ulu-Kilic A, et al. Usefulness of C-reactive protein/albumin ratio as a predictor of new-onset atrial fibrillation in SARS-COV-2. Biomark Med 2021;15:1167-75.
  • 10. Karabacak K, Kubat E, Akyol FB, Kadan M, Erol G, Doğancı S, et al. The C-reactive protein/albumin ratio as a new predictor for postoperative atrial fibrillation after coronary artery bypass graft surgery. J Card Surg 2020;35:2747-53.
  • 11. Kocatürk M, Kocatürk Ö. Assessment of relationship between C-reactive protein to albumin ratio and 90-day mortality in patients with acute ischaemic stroke. Neurol Neurochir Pol 2019;53:205-11.
  • 12. Yu Y, Liu Y, Ling X, Huang R, Wang S, Min J, et al. The neutrophil percentage-to-albumin ratio as a new predictor of all-cause mortality in patients with cardiogenic shock. BioMed Res Int 2020;2020:7458451.
  • 13. Gong Y, Li D, Cheng B, Ying B, Wang B. Increased neutrophil percentage-to-albumin ratio is associated with all-cause mortality in patients with severe sepsis or septic shock. Epidemiol Infect 2020;148:e87.
  • 14. Chavarria N, Wong C, Hussain H, Jooiya HU, Goldbarg S, Buda A. Persistent elevation of neutrophil/lymphocyte ratio associated with new onset atrial fibrillation following percutaneous coronary intervention for acute ST segment elevation myocardial infarction. J Ayub Med Coll Abbottabad 2015;27:441-7.
  • 15. Karavelioğlu Y, Karapınar H, Yüksel M, Memiç K, Sarak T, Kurt R, et al. Neutrophil to lymphocyte ratio is predictor of atrial fibrillation recurrence after cardioversion with amiodarone. Clin Appl Thromb Hemost 2015;21:5-9.
  • 16. Shao Q, Chen K, Rha SW, Lim HE, Li G, Liu T. Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation: a meta-analysis. Arch Med Res 2015;46:199-206.
  • 17. Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010;105:186-91.
  • 18. Ertaş G, Sönmez O, Turfan M, Kul Ş, Erdoğan E, Tasal A, et al. Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation. J Neurol Sci 2013;324:49-52.
  • 19. Shao QM, Xu G, Miao S, Liu E, Yuan R, Li G, et al. Increased neutrophil/lymphocyte ratio and red blood cell distribution width levels in patients with non-valvular atrial fibrillation. Exp Clin Cardiol 2014;20:2827-42.
  • 20. Ji H, Li Y, Fan Z, Zuo B, Jian X, Li L, et al. Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment. BMC Cardiovasc Disord 2017;17:90.

C-reactive protein to albumin ratio in atrial fibrillation

Year 2023, Volume: 9 Issue: 4, 674 - 679, 04.07.2023
https://doi.org/10.18621/eurj.1038532

Abstract

Objectives: Atrial fibrillation (AF) may cause thromboembolism and cardiac morbidity and mortality. Patients with cardiovascular diseases are at risk for developing AF. In this study, the relationship between inflammation markers and AF was examined.


Methods:
Among 689 people followed up in the cardiology outpatient clinic for reasons such as hypertension, coronary artery disease, and rheumatic valve disease, 88 patients with AF and 601 patients without AF were compared. The blood parameters of the AF group were examined during the period when AF developed in the patients. Hemogram and biochemistry parameters of AF and non-AF groups were compared.


Results:
C-reactive protein to albumin ratio (CAR), neutrophil count to albumin ratio, neutrophil count to lymphocyte count ratio, and monocyte count to lymphocyte count ratio were significantly higher in the AF group than in the non-AF group (p < 0.001, p < 0.001, p = 0.001, and p < 0.001; respectively). According to the Receiver Operating Characteristics analysis, it was found that the CAR value of cut-off: 0.0533 could diagnose AF with 74% sensitivity (AUC: 0.789, CI 95%: 0.726-0.853, p < 0.001). Albumin value of cut-off: 3.75 was found to be able to diagnose AF with 82% specificity (AUC: 0.772, CI 95%: 0.707-0.836, p < 0.001).


Conclusions:
AF is an arrhythmia that should be recognized early due to the complications it causes, and the CAR value can be used in the diagnosis of AF in individuals with cardiac disease.

References

  • 1. Macle L, Cairns J, Leblanc K, Tsang T, Skanes A, Cox JL, et al. 2016 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. Can J Cardiol 2016;32:1170-85.
  • 2. Ali-Hassan-Sayegh S, Mirhosseini SJ, Rezaeisadrabadi M, Dehghan HR, Sedaghat-Hamedani F, Kayvanpour E, et al. Antioxidant supplementations for prevention of atrial fibrillation after cardiac surgery: An updated comprehensive systematic review and meta-analysis of 23 randomized controlled trials. Interact Cardiovasc Thorac Surg 2014;18:646-54.
  • 3. Weymann A, Ali-Hasan-Al-Saegh S, Sabashnikov A, Popov AF, Mirhosseini SJ, Liu T, et al. Prediction of new-onset and recurrent atrial fibrillation by complete blood count tests: a comprehensive systematic review with meta-analysis. Med Sci Monit Basic Res 2017;23:179-222.
  • 4. Çınar T, Çağdaş M, Rencüzoğulları İ, Karakoyun S, Karabağ Y, Yesin M, et al. Prognostic efficacy of C-reactive protein/albumin ratio in ST elevation myocardial infarction. Scand Cardiovasc J 2019;53:83-90.
  • 5. Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J Am Coll Cardiol 2011;57:e101-98.
  • 6. Asselbergs FW, van den Berg MP, Diercks GF, van Gilst WH, van Veldhuisen DJ. C-reactive protein and microalbuminuria are associated with atrial fibrillation. Int J Cardiol 2015;98:73-7.
  • 7. Aronson D, Boulos M, Suleiman A, Bidoosi S, Agmon Y, Kapeliovich M, et al. Relation of C-reactive protein and new-onset atrial fibrillation in patients with acute myocardial infarction. Am J Cardiol 2007;100:753-7.
  • 8. Mukamal KJ, Tolstrup JS, Friberg J, Grønbaek M, Jensen G. Fibrinogen and albumin levels and risk of atrial fibrillation in men and women (the Copenhagen City Heart Study). Am J Cardiol 2006;98:75-81.
  • 9. Kelesoglu S, Yilmaz Y, Ozkan E, Calapkorur B, Dursun ZB, Ulu-Kilic A, et al. Usefulness of C-reactive protein/albumin ratio as a predictor of new-onset atrial fibrillation in SARS-COV-2. Biomark Med 2021;15:1167-75.
  • 10. Karabacak K, Kubat E, Akyol FB, Kadan M, Erol G, Doğancı S, et al. The C-reactive protein/albumin ratio as a new predictor for postoperative atrial fibrillation after coronary artery bypass graft surgery. J Card Surg 2020;35:2747-53.
  • 11. Kocatürk M, Kocatürk Ö. Assessment of relationship between C-reactive protein to albumin ratio and 90-day mortality in patients with acute ischaemic stroke. Neurol Neurochir Pol 2019;53:205-11.
  • 12. Yu Y, Liu Y, Ling X, Huang R, Wang S, Min J, et al. The neutrophil percentage-to-albumin ratio as a new predictor of all-cause mortality in patients with cardiogenic shock. BioMed Res Int 2020;2020:7458451.
  • 13. Gong Y, Li D, Cheng B, Ying B, Wang B. Increased neutrophil percentage-to-albumin ratio is associated with all-cause mortality in patients with severe sepsis or septic shock. Epidemiol Infect 2020;148:e87.
  • 14. Chavarria N, Wong C, Hussain H, Jooiya HU, Goldbarg S, Buda A. Persistent elevation of neutrophil/lymphocyte ratio associated with new onset atrial fibrillation following percutaneous coronary intervention for acute ST segment elevation myocardial infarction. J Ayub Med Coll Abbottabad 2015;27:441-7.
  • 15. Karavelioğlu Y, Karapınar H, Yüksel M, Memiç K, Sarak T, Kurt R, et al. Neutrophil to lymphocyte ratio is predictor of atrial fibrillation recurrence after cardioversion with amiodarone. Clin Appl Thromb Hemost 2015;21:5-9.
  • 16. Shao Q, Chen K, Rha SW, Lim HE, Li G, Liu T. Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation: a meta-analysis. Arch Med Res 2015;46:199-206.
  • 17. Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010;105:186-91.
  • 18. Ertaş G, Sönmez O, Turfan M, Kul Ş, Erdoğan E, Tasal A, et al. Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation. J Neurol Sci 2013;324:49-52.
  • 19. Shao QM, Xu G, Miao S, Liu E, Yuan R, Li G, et al. Increased neutrophil/lymphocyte ratio and red blood cell distribution width levels in patients with non-valvular atrial fibrillation. Exp Clin Cardiol 2014;20:2827-42.
  • 20. Ji H, Li Y, Fan Z, Zuo B, Jian X, Li L, et al. Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment. BMC Cardiovasc Disord 2017;17:90.
There are 20 citations in total.

Details

Primary Language English
Subjects Cardiovascular Surgery
Journal Section Original Articles
Authors

Sabri Abuş 0000-0003-2464-4970

Early Pub Date June 1, 2023
Publication Date July 4, 2023
Submission Date December 19, 2021
Acceptance Date March 26, 2022
Published in Issue Year 2023 Volume: 9 Issue: 4

Cite

AMA Abuş S. C-reactive protein to albumin ratio in atrial fibrillation. Eur Res J. July 2023;9(4):674-679. doi:10.18621/eurj.1038532

e-ISSN: 2149-3189 


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