The Effects of Panax ginseng on Serum Oxidative Stress Following Bisphenol A Exposure

Year 2024, , 68 - 72, 26.08.2024

Najiullah Fazalyar , Seren Ede Pazarbaşı , Doğancan Dörücü , Göksel Şener , Tuğba Tunalı Akbay

https://doi.org/10.26650/experimed.1443398

Abstract

Objective: Bisphenol A (BPA) is a toxic compound that causes oxidative stress by disrupting antioxidant enzymes and promoting tissue lipid peroxidation. This study aimed to examine the impacts of BPA on serum oxidative stress in rats and to detect the antioxidant feature of Panax ginseng (PxG) in reducing BPA-induced oxidative stress.
Materials and Methods: Wistar Albino rats (250-300 g) were divided into control, control + PxG, BPA, and BPA + PxG groups. 50 mg/kg BPA and 100 mg/g PxG were given for six weeks. Serum total antioxidant and oxidant status, lipid peroxidation, and glutathione levels were determined.
Results: BPA administration increased total oxidant status and lipid peroxidation, while PxG administration to the BPA group decreased these parameters. PxG also increased total antioxidant status and glutathione levels compared to the BPA group.
Conclusion: BPA was seen to cause an increase in oxidative parameters and PxG administration to restore the oxidative stress that was generated after BPA exposure, suggesting that this may help to prevent the adverse effects caused by BPA exposure.

Keywords

Bisphenol A, Panax ginseng, oxidative stress, antioxidant effect

Supporting Institution

This study was funded by a grant from Marmara University Scientific Research Project Department (Project ID: TYL-2024-11206)

Project Number

TYL-2024-11206

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