The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis

Esra Nur Demirtaş; Selcuk Sozer Tokdemir

doi:10.26650/experimed.1623435

EN

The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis

Abstract

The RNA exosome complex is a multi-subunit ribonuclease complex that participates in RNA degradation, processing, and quality control. In recent years, mutations and dysregulation in the subunits of this complex, which play significant roles in RNA metabolism, have been associated with neurodegenerative diseases, hematological malignancies, and solid tumors. This review discusses the contributions of genes encoding both the catalytic and non-catalytic subunits of the exosome complex to cellular homeostasis, development, and disease pathogenesis. In addition to its roles in RNA homeostasis, the complex also plays a role in maintaining the stability of genomic-resolving DNA:RNA hybrids, regulating telomere integrity, and facilitating homologous recombination. Considering the current literature, this review highlights the potential of RNA exosomes as biomarkers for disease diagnosis and as therapeutic targets for developing new treatment approaches.

Keywords

Supporting Institution

The Research Fund of Istanbul University (Project No: TYL-2022-38465)

Ethical Statement

This research involved the use of publicly available data and did not include any human or animal subjects; therefore, ethics approval was not necessary.

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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Review

Authors

Esra Nur Demirtaş
0000-0002-3533-0697
Türkiye

Selcuk Sozer Tokdemir ^*
0000-0002-5035-4048
Türkiye

Publication Date

August 29, 2025

Submission Date

January 20, 2025

Acceptance Date

April 8, 2025

Published in Issue

Year 2025 Volume: 15 Number: 2

DOI

https://doi.org/10.26650/experimed.1623435

IZ

https://izlik.org/JA99RC24UT

Cite

RIS / Bibtex

APA

Demirtaş, E. N., & Sozer Tokdemir, S. (2025). The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis. Experimed, 15(2), 101-108. https://doi.org/10.26650/experimed.1623435

AMA

1.Demirtaş EN, Sozer Tokdemir S. The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis. Experimed. 2025;15(2):101-108. doi:10.26650/experimed.1623435

Chicago

Demirtaş, Esra Nur, and Selcuk Sozer Tokdemir. 2025. “The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis”. Experimed 15 (2): 101-8. https://doi.org/10.26650/experimed.1623435.

EndNote

Demirtaş EN, Sozer Tokdemir S (August 1, 2025) The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis. Experimed 15 2 101–108.

IEEE

[1]E. N. Demirtaş and S. Sozer Tokdemir, “The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis”, Experimed, vol. 15, no. 2, pp. 101–108, Aug. 2025, doi: 10.26650/experimed.1623435.

ISNAD

Demirtaş, Esra Nur - Sozer Tokdemir, Selcuk. “The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis”. Experimed 15/2 (August 1, 2025): 101-108. https://doi.org/10.26650/experimed.1623435.

JAMA

1.Demirtaş EN, Sozer Tokdemir S. The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis. Experimed. 2025;15:101–108.

MLA

Demirtaş, Esra Nur, and Selcuk Sozer Tokdemir. “The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis”. Experimed, vol. 15, no. 2, Aug. 2025, pp. 101-8, doi:10.26650/experimed.1623435.

Vancouver

1.Esra Nur Demirtaş, Selcuk Sozer Tokdemir. The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis. Experimed. 2025 Aug. 1;15(2):101-8. doi:10.26650/experimed.1623435