Opticospinal Multiple Sclerosis Clinical Course and Immunological Parameters

Abstract

DOI: 10.26650/experimed.2018.18002

Objectives: The clinical course of opticospinal multiple sclerosis (OSMS) is different from that of classical multiple sclerosis (MS) and exhibits a remarkable similarity with that of neuromyelitis optica (NMO). This study aimed to define the immunological parameters of OSMS to distinguish OSMS from classic MS and NMO and to highlight the pathology of OSMS and treatment choice.

Material and Method: In total, 20 patients with MS, 14 with OSMS, 18 with NMO, and 21 healthy controls were enrolled in the study. Serum cytokine levels were measured using the multiple bead method, and the results were compared with those obtained using the post hoc analysis of variance and Tukey’s test.

Results: Interleukin (IL)-8 levels were significantly lower in the MS and OSMS groups than in the NMO and control groups (p<0.0001). IL-6 levels were found to be significantly lower in the NMO and control groups than in the MS and OSMS groups (p=0.042). Tumor necrosis factor alpha ( TNF-α) levels were significantly lower in the NMO and control groups than in the MS and OSMS groups (p<0.0001).

Conclusion: The findings of our study suggest that people with OSMS and NMO exhibit different levels of cytokines and that Aqp-4-negative OSMS, which is not a spinal longitudinal disease, is not a variant of NMO.

Keywords

• Optic nerve,spinal cord,demyelinatic

Optikospinal Multipl Skleroz Klinik Seyir ve İmmünolojik Parametreler

Abstract

DOI: 10.26650/experimed.2018.18002

Amaç: Optikospinal multipl sklerozun (OSMS) klinik seyrinin klasik multipl sklerozdan (MS) farklı olduğu bilinmekte, nöromyelitis optika (NMO) ile de benzerliği dikkat çekmektedir. Biz bu çalışmayla OSMS’i klasik MS ve NM’dan ayıracak immunolojik parametreler tanımlayıp hastalığın seyri ve tedavi seçimi açısından fikir vermesini amaçladık.

Gereç ve Yöntem: Çalışmaya 20 MS, 14 OSMS, 18 NMO ve 21 sağlıklı kontrol olgusu alındı. Serum sitokin düzeyleri çoklu boncuk yöntemi ile ölçüldü. Sonuçlar  ANOVA ve Tukey’in post hoc testi ile karşılaştırıldı.

Bulgular: IL-8 düzeyleri MS ve OSMS gruplarında NMO ve sağlıklı kontrol grubuna göre anlamlı derecede düşük saptandı (p<0,0001). IL-6 düzeyleri ise NMO ve sağlıklı kontrol gruplarında MS ve OSMS grubundan anlamlı derecede düşüktü (p=0.042). Tümör nekrotizan faktör alfa (TNF-α) düzeyine bakıldığında NMO ve sağlıklı kontrol gruplarının MS ve OSMS gruplarından anlamlı derecede düşük olduğu görüldü (p<0,0001).

Sonuç: Çalışmamız OSMS ve NMO hastalarında birbirinden farklı sitokin düzeylerinin olduğunu göstermiş ve özellikle spinal longitüdinal lezyonu olmayan,  Aquaporin-4 (Aqp-4) negatif OSMS’nin bir NMO spektrum hastalığı varyantı olmadığını destekleyen bulgular sunmuştur. 

Keywords

• Optik sinir,spinal kord,demiyelinizan

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