Prognostic Significance of Glutathione Peroxidase (GSH-Px) Levels in Lumbar Degenerative Disc Disease

Abstract

Objective: In this study, the main aim was to research whether decreased antioxidant activity was manifesting the intervertebral disc degeneration in a population in which the degeneration could be compatible with their ages. Material and Method: The study group consisted of 39 patients with lumbar disc degeneration (LDD) and 37 healthy controls. Patient data including age, symptoms, neurological examination findings, lumbar MRI findings, Oswestry Disability Index (ODI) scores, and Visual Analogue Scale of pain (VAS) were used. Human Glutathione peroxidase (GSH-Px) level was determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: Serum GSH-Px levels were significantly lower in the patients with LDD when compared to the healthy controls (p=0.011). Conclusions: In the present study, we demonstrated that, in addition to environmental factors, there is a correlation between GSHPx enzyme deficiency and lumbar disc degeneration.

Keywords

• Glutathione peroxidase
• lumbar degenerative disc disease
• ELISA

Lomber Dejeneratif Disk Hastalığında Glutatyon Peroksidaz (GSH-Px) Düzeylerinin Prognostik Önemi

Abstract

Amaç: Bu çalışmanın temel amacı, yaş nedeniyle disk dejenerasyonu potansiyeli olan bir popülasyonda, azalmış antioksidan aktivitesinin intervertebral disk dejenerasyonu ile ilişkisini araştırmaktır. Gereç ve Yöntem: Çalışmaya lomber disk dejenerasyonu (LDD) tanısı almış 39 hasta ve 37 sağlıklı gönüllü dahil edildi. Hasta verileri yaş, semptomlar, nörolojik muayene bulguları, lomber MRG bulguları, Oswestry Skala (ODI) skorları ve Visüel Analog Skala (VAS) kullanıldı. İnsan Glutatyon peroksidaz (GSH-Px) seviyeleri Enzime Bağlı İmmünosorbent Ölçüm (ELISA) yöntemi ile tespit edildi. Bulgular: Serum GSH-Px düzeylerinin LDD tanısı almış hasta grubunda sağlıklı kontrollere göre anlamlı olarak düşük olduğu belirlendi (p=0,011). Sonuç: Çalışmamızda çevresel faktörlere ek olarak GSH-Px enzim eksikliği ile lomber disk dejenerasyonu arasında bir korelasyon olduğu tespit edilmiştir.

Keywords

• Glutatyon peroksidaz
• lomber dejeneratif disk hastalığı
• ELISA

Supporting Institution

Bu çalışma Yeditepe Üniversitesi Proje Yönetim Ofisi tarafından desteklenmiştir

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