Are Stereotactic Body Radiotherapy and Zoledronic Acid Combination Additive or Synergistic in Bone Metastasis?

Abstract

Bone metastasis is an important cause of morbidity and mortality. In today's oncology practice, zoledronic acid (ZA) and Stereotactic Body Radiotherapy (SBRT) have been widely used in the treatment of bone metastases and in the treatment of bone pain reduction. Whether this combined therapy is additive or synergistic is not yet known. There are not enough studies on this subject yet. To better understand the effects of ZA and SBRT combination therapy, prospective studies including more patients are needed.

Keywords

• Bone metastasis
• SBRT
• zoledronic acid

SBRT ve Zoledronik Asid Kombinasyonu Kemik Metastaz Tedavisinde Aditif veya Sinerjistik Etki Mi Yapar?

Abstract

Kemik metastazı önemli bir morbidite ve mortalite nedenidir. Günümüz onkoloji pratiğinde zoledronik asit ve stereotaktik vücut radyoterapisi (SBRT), kemik metastazlarının tedavisi ve kemik ağrılarının azaltılması tedavisinde yaygın olarak kullanılmaya başlanılmıştır. Bu kombine tedavinin aditif veya sinerjistik etki yapıp yapmadığı henüz bilinmemektedir. Bu konuda henüz yeterli çalışma bulunmamaktadır. Zoledronik asit ve SBRT kombinasyon tedavisinin etkilerinin daha iyi anlaşılabilmesi için prospektif ve daha çok sayıda hastayı içeren çalışmalara ihtiyaç vardır.

Keywords

• Kemik metastazı
• SBRT
• zoledronik asit

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