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Kosova Gjilan Şehrindeki Okul Çağı Çocuklarını İçeren Popülasyonda Alerjik Rinit ve Egzamanın İncelenmesi

Year 2019, Volume: 9 Issue: 3, 113 - 119, 01.12.2019

Abstract

DOI: 10.26650/experimed.2019.19018

Amaç: Çalışmada Kosova Gjilan şehrindeki okullarda 13-14 yaşlarındaki çocuklardan oluşan popülasyonda, alerjik rinit ve egzama klinik semptomlarının cinsiyet farklılığı açısından araştırılması amaçlanmıştır.

Gereç ve Yöntem: Ebeveynlerin/velilerin pasif onayı alınarak, yaşları 13-14 arasında değişen 1200 çocuk farklı okullardan seçilerek çalışmaya dahil edilmiştir. Çalışma burun ve deri problemleri ile ilişkili soruları kapsayan verilerin analizinden oluşmaktadır (53 sorudan 14’ü).

Bulgular: Alerjik rinit ilişkili yaygınlıklar; a) Hapşırma, burun akıntısı veya tıkalı burun gibi durumlar popülasyon genelinde %34,20 olarak saptandı. Bunlardan son 12 aydır bu şikayetlere sahip olanların %25’lik dilimi oluşturduğu görüldü. b) Bahar nezlesi ise %14,5 olarak bulundu. Egzama ilişkili yaygınlıklar; a) Kaşıntılı döküntüler son 12 aylık dönemde incelendiğinde %7,5 olarak görüldü. b) Yaşamı boyunca az bir kere egzama görülenlerin %4,2’ lik dilimi oluşturduğu belirlendi.

Sonuç: Alerjik rinitle ilişkili belirtiler kız çocuklarında erkeklere oranla daha yüksek bir yatkınlıkla ilişkili bulunurken, egzama belirtileri ve cinsiyet arasında istatiksel olarak anlamlı bir ilişki bulunamadı.

Cite this article as: Gashi V, Ahmetaj LN, Ahmeti B. Allergic Rhinitis and Eczema in a Population of School Children from the City of Gjilan in Kosovo. Experimed 2019; 9(3): 113-9.

References

  • 1. Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med 1992; 327: 571-2. [CrossRef] 2. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009; 64: 476-83. [CrossRef] 3. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 2001; 357: 313-4. 4. Ferkol T, Schraufnagel D. The global burden of respiratory disease. Ann Am Thorac Soc 2014; 11: 404-6. [CrossRef] 5. de Korte-de Boer D, Mommers M, Gielkens-Sijstermans CM, Creemers HM, Mujakovic S, Feron FJ, et al. Stabilizing prevalence trends of eczema, asthma and rhinocon-junctivitis in Dutch schoolchildren (2001-2010). Allergy 2015; 70: 1669-73. [CrossRef] 6. Sybilski AJ, Raciborski F, Lipiec A, Tomaszewska A, Lusawa A, Samel-Kowalik P, et al. Epidemiology of atopic dermatitis in Poland according to the Epidemiology of Allergic Disorders in Poland (ECAP) study. J Dermatol 2015; 42: 140-7. [CrossRef] 7. Bousquet J, Annesi-Maesano I, Carat F, Leger D, Rugina M, Pribil C, et al. Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy 2005; 35: 728-32. [CrossRef] 8. Linneberg A, Henrik Nielsen N, Frolund L, Madsen F, Dirksen A, Jorgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2002; 57: 1048-52. [CrossRef] 9. Ronmark EP, Ekerljung L, Mincheva R, Sjolander S, Hagstad S, Wennergren G, et al. Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study. Clin Transl Allergy 2016; 6: 28. doi: 10.1186/s13601-016-0112-0. [CrossRef] 10. Downie SR, Andersson M, Rimmer J, Leuppi JD, Xuan W, Akerlund A, et al. Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitis. Allergy 2004; 59: 320-6. [CrossRef] 11. Corren J, Adinoff AD, Buchmeier AD, Irvin CG. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J Allergy Clin Immunol 1992; 90: 250-6. [CrossRef] 12. Taramarcaz P, Gibson PG. Intranasal corticosteroids for asthma control in people with coexisting asthma and rhinitis. Cochrane Database Syst Rev 2003; CD003570. [CrossRef] 13. Leynaert B, Neukirch C, Kony S, Guénégou A, Bousquet J, Aubier M, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004; 113: 86-93. [CrossRef] 14. Hill DA, Spergel JM. The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol 2018; 120: 131-7. [CrossRef] 15. Bantz SK, Zhu Z, Zheng T. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. J Clin Cell Immunol 2014; 5: 202. doi: 10.4172/2155-9899.1000202 [CrossRef] 16. Pols DH, Wartna JB, van Alphen EI, Moed H, Rasenberg N, Bindels PJ, et al. Interrelationships between atopic disorders in children: A meta-analysis based on ISAAC questionnaires. PLoS One 2015; 10: doi: 10.1371/journal.pone.0131869. [CrossRef] 17. Lawson V, Lewis-Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the Dermatitis Family Impact Questionnaire. Br J Dermatol 1998; 138: 107-13. [CrossRef] 18. Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. J Invest Dermatol 2017; 137: 26-30. [CrossRef] 19. Lindberg M, Isacson D, Bingefors K. Self-reported skin diseases, quality of life and medication use: a nationwide pharmaco-epidemiological survey in Sweden. Acta Derm Venereol 2014; 94: 188-91. [CrossRef] 20. Muraro A, Fokkens WJ, Pietikainen S, Borrelli D, Agache I, Bousquet J, et al. European symposium on precision medicine in allergy and airways diseases: Report of the European Union Parliament Symposium (October 14, 2015). Allergy 2016; 71: 583-7. [CrossRef] 21. Gough H, Grabenhenrich L, Reich A, Eckers N, Nitsche O, Schramm D, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol 2015; 26: 431-7. [CrossRef] 22. Osman M. Therapeutic implications of sex differences in asthma and atopy. Arch Dis Child 2003; 88: 587-90. [CrossRef] 23. Whitacre CC, Reingold SC, O’Looney PA. A gender gap in autoimmunity. Science 1999; 283: 1277-8. [CrossRef] 24. Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A; ISAAC Phase Three Study Group. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis. Allergol Immunopathol (Madr) 2013; 41: 73-85. [CrossRef] 25. Aït-Khaled N, Pearce N, Anderson HR, Ellwood P, Montefort S, Shah J, et al. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Allergy Eur J Allergy Clin Immunol 2009; 64: 123-48. [CrossRef] 26. Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI; ISAAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 2009; 124: 1251-8. [CrossRef] 27. Osman M, Tagiyeva N, Wassall HJ, Ninan TK, Devenny AM, McNeill G, et al. Changing trends in sex specific prevalence rates for childhood asthma, eczema, and hay fever. Pediatr Pulmonol 2007; 42: 60-5. [CrossRef] 28. Fröhlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C, et al. Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy 2017; 7: doi: 10.1186/s13601-017-0176-5. [CrossRef] 29. Austin JB, Kaur B, Anderson HR, Burr M, Harkins LS, Strachan DP, et al. Hay fever, eczema, and wheeze: A nationwide UK study (ISAAC, international study of asthma and allergies in childhood). Arch Dis Child 1999; 103: 125-38. [CrossRef] 30. Taborda-Barata L, Gama JMR, Rosado-Pinto J, Lulua O, Quifica F, Arrais M. Prevalence of asthma and allergies in 13-14-year-old adolescents from Luanda, Angola. Int J Tuberc Lung Dis. 2017; 21: 705-12. [CrossRef] 31. Bonds RS, Midoro-Horiuti T. Estrogen effects in allergy and asthma. Curr Opin Allergy Clin Immunol 2013; 13: 92-9. [CrossRef] 32. Chen W, Mempel M, Schober W, Behrendt H, Ring J. Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy 2008; 63: 1418-27. [CrossRef] 33. Roved J, Westerdahl H, Hasselquist D. Sex differences in immune responses: Hormonal effects, antagonistic selection, and evolutionary consequences. Horm Behav 2017; 88: 95-105. [CrossRef] 34. Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, et al. Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation. Cell Rep 2017; 21: 2487-99. [CrossRef]

Allergic Rhinitis and Eczema in a Population of School Children from the City of Gjilan in Kosovo

Year 2019, Volume: 9 Issue: 3, 113 - 119, 01.12.2019

Abstract

DOI: 10.26650/experimed.2019.19018

Objective: The goal of this study was to investigate the gender difference in manifestation of clinical symptoms related to allergic rhinitis and eczema in a population of school children aged 13-14 years from the city of Gjilan in Kosovo.

Material and method: About 1200 school children aged between 13-14 years, from randomly selected schools, were included in the study, once the passive consent of their parents/guardians had been received. This study covers the data analysis from the questions related to the nose and skin problems (14 out of 53 questions).

Results: Prevalence related to allergic rhinitis; a) sneezing, or a runny or blocked nose ever was 34.20% and in the last 12 months it was 25%; and b) hay fever ever was 14.5%. Prevalence related to eczema,; a) itchy rash at any time in the past 12 months was 7.5%; and b) eczema ever in life was 4.2%.

Conclusion: This study found a higher prevalence of allergic rhinitis symptoms in female children comparing to male, while no significant connection was found between gender and eczema symptoms.

Cite this article as: Gashi V, Ahmetaj LN, Ahmeti B. Allergic Rhinitis and Eczema in a Population of School Children from the City of Gjilan in Kosovo. Experimed 2019; 9(3): 113-9.

References

  • 1. Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med 1992; 327: 571-2. [CrossRef] 2. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009; 64: 476-83. [CrossRef] 3. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 2001; 357: 313-4. 4. Ferkol T, Schraufnagel D. The global burden of respiratory disease. Ann Am Thorac Soc 2014; 11: 404-6. [CrossRef] 5. de Korte-de Boer D, Mommers M, Gielkens-Sijstermans CM, Creemers HM, Mujakovic S, Feron FJ, et al. Stabilizing prevalence trends of eczema, asthma and rhinocon-junctivitis in Dutch schoolchildren (2001-2010). Allergy 2015; 70: 1669-73. [CrossRef] 6. Sybilski AJ, Raciborski F, Lipiec A, Tomaszewska A, Lusawa A, Samel-Kowalik P, et al. Epidemiology of atopic dermatitis in Poland according to the Epidemiology of Allergic Disorders in Poland (ECAP) study. J Dermatol 2015; 42: 140-7. [CrossRef] 7. Bousquet J, Annesi-Maesano I, Carat F, Leger D, Rugina M, Pribil C, et al. Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy 2005; 35: 728-32. [CrossRef] 8. Linneberg A, Henrik Nielsen N, Frolund L, Madsen F, Dirksen A, Jorgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2002; 57: 1048-52. [CrossRef] 9. Ronmark EP, Ekerljung L, Mincheva R, Sjolander S, Hagstad S, Wennergren G, et al. Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study. Clin Transl Allergy 2016; 6: 28. doi: 10.1186/s13601-016-0112-0. [CrossRef] 10. Downie SR, Andersson M, Rimmer J, Leuppi JD, Xuan W, Akerlund A, et al. Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitis. Allergy 2004; 59: 320-6. [CrossRef] 11. Corren J, Adinoff AD, Buchmeier AD, Irvin CG. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J Allergy Clin Immunol 1992; 90: 250-6. [CrossRef] 12. Taramarcaz P, Gibson PG. Intranasal corticosteroids for asthma control in people with coexisting asthma and rhinitis. Cochrane Database Syst Rev 2003; CD003570. [CrossRef] 13. Leynaert B, Neukirch C, Kony S, Guénégou A, Bousquet J, Aubier M, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004; 113: 86-93. [CrossRef] 14. Hill DA, Spergel JM. The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol 2018; 120: 131-7. [CrossRef] 15. Bantz SK, Zhu Z, Zheng T. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. J Clin Cell Immunol 2014; 5: 202. doi: 10.4172/2155-9899.1000202 [CrossRef] 16. Pols DH, Wartna JB, van Alphen EI, Moed H, Rasenberg N, Bindels PJ, et al. Interrelationships between atopic disorders in children: A meta-analysis based on ISAAC questionnaires. PLoS One 2015; 10: doi: 10.1371/journal.pone.0131869. [CrossRef] 17. Lawson V, Lewis-Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the Dermatitis Family Impact Questionnaire. Br J Dermatol 1998; 138: 107-13. [CrossRef] 18. Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. J Invest Dermatol 2017; 137: 26-30. [CrossRef] 19. Lindberg M, Isacson D, Bingefors K. Self-reported skin diseases, quality of life and medication use: a nationwide pharmaco-epidemiological survey in Sweden. Acta Derm Venereol 2014; 94: 188-91. [CrossRef] 20. Muraro A, Fokkens WJ, Pietikainen S, Borrelli D, Agache I, Bousquet J, et al. European symposium on precision medicine in allergy and airways diseases: Report of the European Union Parliament Symposium (October 14, 2015). Allergy 2016; 71: 583-7. [CrossRef] 21. Gough H, Grabenhenrich L, Reich A, Eckers N, Nitsche O, Schramm D, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol 2015; 26: 431-7. [CrossRef] 22. Osman M. Therapeutic implications of sex differences in asthma and atopy. Arch Dis Child 2003; 88: 587-90. [CrossRef] 23. Whitacre CC, Reingold SC, O’Looney PA. A gender gap in autoimmunity. Science 1999; 283: 1277-8. [CrossRef] 24. Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A; ISAAC Phase Three Study Group. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis. Allergol Immunopathol (Madr) 2013; 41: 73-85. [CrossRef] 25. Aït-Khaled N, Pearce N, Anderson HR, Ellwood P, Montefort S, Shah J, et al. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Allergy Eur J Allergy Clin Immunol 2009; 64: 123-48. [CrossRef] 26. Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI; ISAAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 2009; 124: 1251-8. [CrossRef] 27. Osman M, Tagiyeva N, Wassall HJ, Ninan TK, Devenny AM, McNeill G, et al. Changing trends in sex specific prevalence rates for childhood asthma, eczema, and hay fever. Pediatr Pulmonol 2007; 42: 60-5. [CrossRef] 28. Fröhlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C, et al. Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy 2017; 7: doi: 10.1186/s13601-017-0176-5. [CrossRef] 29. Austin JB, Kaur B, Anderson HR, Burr M, Harkins LS, Strachan DP, et al. Hay fever, eczema, and wheeze: A nationwide UK study (ISAAC, international study of asthma and allergies in childhood). Arch Dis Child 1999; 103: 125-38. [CrossRef] 30. Taborda-Barata L, Gama JMR, Rosado-Pinto J, Lulua O, Quifica F, Arrais M. Prevalence of asthma and allergies in 13-14-year-old adolescents from Luanda, Angola. Int J Tuberc Lung Dis. 2017; 21: 705-12. [CrossRef] 31. Bonds RS, Midoro-Horiuti T. Estrogen effects in allergy and asthma. Curr Opin Allergy Clin Immunol 2013; 13: 92-9. [CrossRef] 32. Chen W, Mempel M, Schober W, Behrendt H, Ring J. Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy 2008; 63: 1418-27. [CrossRef] 33. Roved J, Westerdahl H, Hasselquist D. Sex differences in immune responses: Hormonal effects, antagonistic selection, and evolutionary consequences. Horm Behav 2017; 88: 95-105. [CrossRef] 34. Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, et al. Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation. Cell Rep 2017; 21: 2487-99. [CrossRef]
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Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Valbona Gashi This is me

Luljeta N. Ahmetaj This is me

Bekim Ahmeti This is me

Publication Date December 1, 2019
Submission Date August 28, 2019
Published in Issue Year 2019 Volume: 9 Issue: 3

Cite

Vancouver Gashi V, Ahmetaj LN, Ahmeti B. Allergic Rhinitis and Eczema in a Population of School Children from the City of Gjilan in Kosovo. Experimed. 2019;9(3):113-9.