Comparing the VDR Gene BsmI and CDX2Polymorphisms in Healthy Turks and Healthy Somalians Living in Turkiye

Year 2022, Volume: 12 Issue: 3, 168 - 173, 31.12.2022

Ender Coşkunpınar , Betul Nılgun Engın

https://doi.org/10.26650/experimed.1197719

Abstract

Objectives: This study aimed to evaluate genotypic and allelic differences by comparing the Vitamin D (Vit-D) receptor (VDR) gene BsmI(rs1544410) and CDX2 (rs11568820) polymorphisms in healthy Turks and healthy Somalians living in Turkiye.

Materials and Methods: The study involved 100 healthy Turkish individuals and 60 healthy Somali individuals residing in Turkiye for at least 5 years. The genotyping study was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific PCR methods. Statistical analysis was performed to identify the possible differences between groups using the Chi-square and Student’s t tests for pair-wise comparisons.

Results: According to the data obtained in the study with regard to the BsmI (rs1544410 A/G) and CDX2 (rs11568820 A/G) genotypes, no statistically significant difference was determined to be present regarding the frequency of carrying the mutant GG genotype in the two groups (p = 0.95 and p = 0.221, respectively).

Conclusion: The study has found no significant genotypic or allelic difference to be present in terms of the BsmI (rs1544410) and CDX2(rs11568820) gene variants between healthy Turkish individuals and Somali individuals who have spent most of their lives exposed to less sunlight while living in Turkiye for the past five years.

Keywords

VDR, BsmI (rs1544410), CDX2 (11568820), polymorphism

Supporting Institution

TÜBİTAK

Project Number

1919B012101611

Thanks

This study was supported by TUBITAK with the project number "1919B012101611". We thank TÜBİTAK for its support.

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